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  • Polymer and Materials Science  (12)
  • Chemical Engineering  (5)
  • Nuclear reactions  (4)
  • hypertension  (3)
  • Adaptation  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section A 307 (1978), S. 224-238 
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section A 229 (1974), S. 189-203 
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section A 201 (1973), S. 1-20 
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics, Section A 332 (1979), S. 297-316 
    ISSN: 0375-9474
    Keywords: Nuclear reactions
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 72 (1988), S. 1-20 
    ISSN: 1432-1106
    Keywords: Vision ; Visual cortex ; Adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Motion after-effects were elicited from striate cortical cells in lightly-anaesthetized cats, by adapting with square-wave gratings or randomly textured fields drifting steadily and continuously in preferred or null directions. The time-course and recovery of responsiveness following adaptation were assessed with moving bars, gratings or textured fields. Results were compared with controls in which the adapting stimulus was replaced by a uniform field of identical mean luminance, and also assessed in relation to the strength and time course of adaptation. Within 30–60 s adaptation, firing declined to a steady-state. Induced after-effects were direction-specific, and manifest as a transitory depression in response to the direction of prior adaptation, recovering to control levels in 30–60 s. Maximal after effects were induced by gratings of optimal drift velocity and spatial frequency. With rare exceptions after-effects were restricted to driven activity; no consistent effects on resting discharge were observed. The onset of adaptation, and the recovery period, were more rapid in simple cells, although after effects of comparable strength were elicited from simple and from standard complex cells. Special complex cells, including many of the more profoundly texture-sensitive neurones in the cortex, were more resistant to adaptation. The results support the conclusion that psychophysically measured adaptation and induced motion after-effect phenomena reflect the known properties of cortical neurones.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 60 (1985), S. 71-78 
    ISSN: 1432-1106
    Keywords: Motion ; Velocity ; Visual cortex ; Adaptation ; Texture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Interactions between two different visual patterns, a coarse grating and a fine texture pattern, were investigated in the context of velocity aftereffects in human subjects. The perceived velocity shift, in which the perceived velocity of a moving test pattern is reduced following exposure to a similarly moving adaptation pattern, is apparent when the adaptation and test patterns are of the same or different types. The aftereffect transfers interocularly in both cases. The directional tuning of the aftereffect is broad, and has a different profile for texture adaptation than for bar adaptation. When adaptation is to a composite stimulus comprising independently moving bars and texture, the aftereffect varies according to the nature of the test pattern. The results are discussed with reference to interactions between the responses of neurones in feline striate cortex to the two types of pattern.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1041
    Keywords: debrisoquine ; hypertension ; renin ; catecholamines ; platelet monoamine oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The 24 h urinary excretion of adrenaline, noradrenaline, metadrenaline, normetadrenaline and vanillylmandelic acid, plasma renin activity and plasma and urinary debrisoquine were measured before and during chronic treatment with oral debrisoquine in 14 in-patients with essential hypertension. There was a significant fall (mean ±SD) in the 24 h urinary excretion of vanillylmandelic acid (15.3±2.8 to 6.7±1.9 µmol) noradrenaline (199.0±105.8 to 125.2±43.3 nmol) and plasma renin activity (0.71±0.47 to 0.40±0.20 pmol Angio I ml−1 h−1) while the urinary normetadrenaline/noradrenaline ratio increased (10.4±6.1 to 17.1±5.1). No significant change was seen in the output of adrenaline or of O-methylated metabolites. Debrisoquine produces extensive noncompetitive inhibition of platelet monoamine oxidase in vivo at low therapeutic plasma concentrations. These changes support the view that treatment with debrisoquine produces intraneuronal inhibition of monoamine oxidase and post-ganglionic blockage. There was a significant correlation between the change in standing diastolic blood pressure and the daily dose (rs=−0.52), pre-dose plasma concentration (rs=−0.85) and mean daily urinary recovery (rs=−0.80), of debrisoquine. The full extent of the biochemical changes were seen at low dose and low plasma concentration and were not directly correlated with the fall in standing or supine blood pressure.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 29 (1985), S. 33-36 
    ISSN: 1432-1041
    Keywords: cold sensitivity ; hypertension ; alpha- and beta-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The presence of cold sensitivity was investigated in three groups of patients; untreated hypertensives and hypertensives treated by a beta-adrenoceptor blocker (propranolol) or by a combined alpha-and beta-adrenoceptor blocker (labetalol) at two ambient temperatures. At a comfortable ambient (24°C) one-third of the untreated and those treated with beta-blockade only showed cold sensitivity as compared with 16% of patients on the combined therapy. Under conditions of mild cold stress (20°C) cold sensitivity increased in frequency in all three groups, more than half of the untreated and beta-blocked patients were affected and greater than one-third of those with alpha- and beta-blockade. These findings indicate that in the general population of hypertensives treatment with beta-adrenoceptor blockade alone may have little effect on the peripheral vasculature and that a useful degree of protection may be provided by therapy which blocks both receptors.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 14 (1978), S. 383-390 
    ISSN: 1432-1041
    Keywords: Acebutolol ; N-acetyl metabolite ; drug plasma concentrations ; plasma renin activity ; hypertension ; β-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Relationships between plasma concentrations of acebutolol (Ac) and its N-acetyl metabolite (Am) and pharmacological effects were studied in patients with essential hypertension. In an acute study (N=7) 400 mg oral acebutolol produced similar peak plasma levels of Ac and Am but Am had a longer half life. Group mean pulse and blood pressure fell significantly, although the size of individual blood pressure fall varied five-fold. There was no significant change in plasma renin activity. Correlations were found between drug concentration and β-blockade, assessed as % reduction in exercise tachycardia, and between both of these and the fall in post exercise systolic blood pressure. Similar comparisons were made in a chronic optimum dose study (N=11) both pre-dose and three hours post-dose. Am concentration was consistently higher than Ac at both times. Blood pressure was lowered equally pre-and post-dose when compared to placebo and plasma renin activity (PRA) was reduced on active treatment. Correlations were again shown between drug concentrations and β-blockade but none were found with changes in blood pressure or PRA. Between subject differences in blood pressure response could not be fully explained in terms of the other measurements but it is unlikely that pharmacokinetic differences are the major source of this variability.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 29 (1989), S. 433-440 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The flow of Newtonian and non-Newtonian fluids which obeys a power law relationship between shear stress and shear rate has been modeled in the melt conveying section of a self-wiping co-rotating twin-screw extruder using a finite element analysis of an unwound channel section. Predictions of throughput against pressure gradient are compared with experimentally obtained results for maize grits which is represented as a power law material. Rheological data applicable to extrusion simulation were obtained from capillary rheometry. Comparisons are reasonable with predicted characteristic showing similar behavior.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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