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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 233 (1983), S. 281-294 
    ISSN: 1432-0711
    Keywords: Adenosarcoma ; Adenofibroma ; Uterus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven biphasic uterine tumors with epithelial components and homologous stroma were reevaluated. Originally these were diagnosed as adenofibroma, adenosarcoma, carcinosarcoma, or mixtures thereof, but were now reclassified as adenosarcomas of which seven were “pure” and four mixed with foci of carcinosarcoma. Nine of the tumors arose in the endometrium and two in the endocervix. The mean patient's age was 55 years. The most common complaint was vaginal bleeding. Macroscopically these tumors presented as polypoid masses. The epithelial component consisted mainly of endometrial, endocervical, ciliated, and clear cells. Squamous metaplasia and focal hyperplasia were occasionally observed. Malignant epithelial change was only present in foci of carcinosarcoma. The stroma showed prominent cellular periglandular cuffs, occasionally round solid or perivascular nodules, and areas of focal or diffuse stromal hypercellularity. In all these areas stromal cells were atypical and/or pleomorphic. Stromal foam cells were seen in three cases. Mitotic activity was low ranging from one to three mitoses per 10 high power fields (HPF). Follow-up was negative exept in two cases with recurrence and abdominal metastases. It was concluded that stromal hypercellularity with atypism and pleomorphism in periglandular, perivascular location as well as of focal or diffuse nature, is characteristic of uterine adenosarcoma. Adenofibromas present a fibro-collagenous stroma lacking the crowded cellular areas. Mitotic activity is too variable to serve as a reliable diagnostic criterion. Uterine adenosarcomas are usually tumors of low grade malignancy but the lack of correlation between histologic appearance and biologic behaviour precludes prognostication in the individual patient.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Keywords: Endometriosis ; Adenomyosis ; Endometrial function ; Correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Hormontherapie der Adenomyose und Endometriose läßt die Beurteilungsmöglichkeit des Heilungserfolges bzw. der Heilungschancen aus dem Funktionszustand des Corpusendometrium wünschenswert erscheinen. Bei systematischer korrelierender Untersuchung von Endometrium, Adenomyose und/oder Endometriose unter dem Einfluß endogener und exogener hormoneller Stimulation ergaben sich je nach Lokalisation des ektopischen Endometrium und nach Art des hormonellen Stimulus in Zeitpunkt und Ausmaß unterschiedliche Abweichungen vom Funktionszustand des Corpusendometrium. Diese lassen sich jedoch mit genügender Sicherheit jeweils voraussagen. Die hormonelle Stimulierung der Adenomyose war der des Corpusendometrium am ähnlichsten, die Endometriose des Ovars zeigte oft, insbesondere unter Gestagenreizen, eine überschießende Stimulation, während die übrigen extrauterinen Endometriosherde nur sehr schwach auf hormonelle Reize reagierten. Aus den Ergebnissen lassen sich für die Therapie wichtige prognostische Konsequenzen ableiten.
    Notes: Summary This study was undertaken to determine whether the hormonal sensitivity of the endometrium might be a measure of the effectiveness of hormonal therapy for adenomyosis and endometriosis. Accordingly, the effects of endogenous and exogenous hormones on the endometrium, adenomyosis, and endometriosis were correlated. The results revealed that, depending on where the ectopic endometrial tissue was located and on the type (duration and intensity) of hormonal treatment, the functional response of the endometriosis varied from that of the endometrium. The variations, however, can be predicted. The response of adenomyosis to hormonal stimulation was most like that of the endometrium. Endometriosis of the ovary often revealed an excessive response to stimulation, especially after gestagens. The other types of extrauterine foci of endometriosis, however, reacted only weakly to hormonal therapy. Important prognostic consequence for therapy can be drawn from the results.
    Type of Medium: Electronic Resource
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