ISSN:
1435-1463
Keywords:
Adenosine
;
cardiac sensory nerves
;
non-adrenergic non-cholinergic neurotransmission
;
Gi proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The negative inotropic effect of adenosine (1–100 μM) was abolished in isolated guinea-pig atria obtained from pertussis toxin-pretreated guinea pigs electrically driven at 4 Hz. However, the inhibitory effect of the same concentrations of adenosine on the cardiac response to stimulation of non-adrenergic non-cholinergic (NANC), capsaicin-sensitive sensory nerves, was not modified by the toxin. These results suggest that, while pertussis toxin-sensitive G proteins are involved in the negative inotropic effect of adenosine, they do not mediate the inhibitory effect of adenosine on cardiac NANC neurotransmission.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01245161
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