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  • Polymer and Materials Science  (14)
  • Adenosine deaminase  (2)
  • Catalepsy  (2)
  • Recombinant DNA  (2)
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Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Cloning of the hexA mismatch-repair gene of Streptococcus pneumoniae and identification of the product
    Amsterdam : Elsevier
    Gene 34 (1985), S. 293-303 
    Details
    ISSN: 0378-1119
    Keywords: Recombinant DNA ; complementation ; in vitro transcription-translation ; marker effect ; transformation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(85)90138-6
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  • 2
    Electronic Resource
    Electronic Resource
    The difficulty of cloning Streptococcus pneumoniae mal and ami loci in Escherichia coli: toxicity of malX and antiA gene products
    Amsterdam : Elsevier
    Gene 80 (1989), S. 227-238 
    Details
    ISSN: 0378-1119
    Keywords: Recombinant DNA ; lipoproteins ; overexpression ; plasmid copy number ; protein export ; strong promoters ; transcriptional terminator
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0378-1119(89)90287-4
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence for separate neuronal mechanisms for the discriminative stimulus and catalepsy induced by Δ9-THC in the rat (1992)
    Springer
    Psychopharmacology 107 (1992), S. 117-124 
    Details
    ISSN: 1432-2072
    Keywords: Discriminative stimulus ; Catalepsy ; Marijuana ; Δ9-Tetrahydrocannabinol ; Opiate ; Neuroleptic ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cataleptogenic effect of Δ9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of Δ9-THC for catalepsy in experimentally naive rats was not different from that in rats trained with the drug discrimination procedure, indicating that the cataleptogenic effect was not appreciably attenuated by long-term exposure to low doses of Δ9-THC. Pharmacologically, the catalepsy produced by Δ9-THC more closely resembled that of haloperidol than of morphine, since anticholinergic pretreatment eliminated the Δ9-THC-induced catalepsy while pre-treatment with naloxone had no effect. Although the cataleptogenic effect of Δ9-THC could be pharmacologically manipulated by anticholinergic pre-treatment, its discriminative stimulus effects were not changed in the same animals. These results demonstrate that distinctive mechanisms of action exist for these cannabinoid-induced behaviors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244975
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  • 4
    Electronic Resource
    Electronic Resource
    Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats (1995)
    Springer
    Psychopharmacology 119 (1995), S. 282-290 
    Details
    ISSN: 1432-2072
    Keywords: Radial-arm maze ; Δ9-tetrahydrocannabinol (Δ9-THC) ; CP-55,940 ; WIN-55,212-2 ; Anandamide ; Cannabidiol ; Hippocampus ; Antinociception ; Catalepsy ; Rectal temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of the present study was to investigate the disruptive effects of cannabinoids on working memory as assessed in the eight-arm radial-maze. Systemic administration of Δ9-THC, WIN-55,212-2, and CP-55,940 increased the number of errors committed in the radial-maze. CP-55,940 was the most potent cannabinoid in impairing memory (ED50=0.13 mg/kg). Δ9-THC and WIN-55,212-2 disrupted mazechoice accuracy at equipotent doses (ED50 values =2.1 and 2.2 mg/kg, respectively). In addition, systemic administration of each of these agents retarded completion time. Whereas the doses of Δ9-THC and CP-55,940 required to retard maze performance were higher than those needed to increase error numbers, WIN-55,212-2 was equipotent in both of these measures. On the other hand, neither anandamide, the putative endogenous cannabinoid ligand, nor cannabidiol, an inactive naturally occurring cannabinoid, had any apparent effects on memory. A second aim of this study was to elucidate the neuroanatomical substrates mediating the disruptive effects of cannabinoids on memory. Intrahippocampal injections of CP-55,940 impaired maze performance in a dose-dependent manner (ED50=8 µg/rat), but did not retard the amount of time required to complete the maze. The effects of intrahippocampal CP-55,940 were apparently specific to cognition because no other cannabinoid pharmacological effects (e.g., antinociception, hypothermia, and catalepsy) were detected. This dissociation between choice accuracy in the radial-maze and other cannabinoid pharmacological effects suggests that the working memory deficits produced by cannabinoids may be mediated by cannabinoid receptors in the hippocampus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246292
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 240-251 
    Details
    ISSN: 1435-1803
    Keywords: Adenosine deaminase ; microdialysis ; micropig ; myocardial blood flow ; pentostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to examine the relationship between local adenosine concentrations before, during, and after ischemia and the extent of ischemic myocardial damage, measurements of interstitial fluid (ISF) nucleosides were made using microdialysis probes implanted in the ischemic region of isoflurane anesthetized Micropigs undergoing 60′ coronary artery occlusion (CAO) and 3h of reperfusion (REP). Nucleoside concentrations in the dialysate collected from the microdialysis probes were used as an index of ISF levels. Dialysate nucleoside concentrations (ADO, inosine and hypoxanthine), myocardial infarct size, and myocardial blood flow (MBF) were determined in control animals (n=6), animals preconditioned with a single 10′ cycle of CAO and REP (PC, n=6), and those treated with the adenosine deaminase inhibitor pentostatin (n=6, 0.2 mg/Kg IV 30′ prior to CAO). The brief PC occlusion resulted in a transient but significant increase in dialysate ADO (6.7±1.8 μM vs. 0.67±0.1 μM at baseline). Pentostatin administration had no significant effect on either dialysate nucleosides or MBF at baseline. During the 60′ CAO, dialystate ADO increased in control animals. In PC animals, however, dialysate ADO during CAO was lower than control. Pretreatment with pentostatin resulted in a six-fold augmentation in dialysate ADO during the 60 min CAO when compared to the control values (110.62±30.2 μM vs. 16.31±2.1 μM at 60 min of ischemia). Pentostatin also resulted in a significant reduction in the accumulation of inosine and hypoxanthine, indicating inhibition of adenosine deaminase activity. There were no significant differences in MBF between groups at any time point. Following 3 h REP, infarct size was 35.4±5.5%, 8.1±1.5% and 8.3±1.8% of the region at control, PC, and pentostatin groups, respectively. These data suggest that marked increase in ISF ADO during CAO, may be as effective in reducing INF as a modest increase in ISF ADO prior to prolonged CAO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788519
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of adenosine deaminase inhibition with pentostatin on myocardial stunning in dogs (1995)
    Springer
    Basic research in cardiology 90 (1995), S. 176-183 
    Details
    ISSN: 1435-1803
    Keywords: Adenosine deaminase ; adenosine ; myocardial stunning ; sonomicrometers ; microspheres ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study was to determine if adenosine deaminase inhibition with pentostatin could improve postischemic contractile dysfunction (stunning) in open-chest anesthetized dogs. All animals underwent 15 min of coronary occlusion followed by 3 h of reperfusion preceded by an intravenous bolus of either 0.2 mg/kg of pentostatin (n=8) or saline (n=7). Sonomicrometers were plced in the ischemic area and were used to measure systolic wall thickening before, during, and after occlusion of the left anterior descending artery. Myocardial blood flow was measured with tracer labeled microspheres at baseline, 10 min of occlusion and at 1 h of reperfusion. Both groups were equally dyskinetic during occlusion (−21±5% of baseline thickening in the controls and −28±8% in the pentostatin group). The pentostatin group, however, demonstrated better contractile function at all time points during reperfusion, which was significantly different from the control group at 3 h of reperfusion. The improvement in regional function in the pentostatin group was not due to significant disparities in hemodynamic variables, size of the region at risk, or in collateral blood flow. These results indicate that pentostatin can ameliorate the severity of myocardial stunning, an effect we propose is due to increasing endogenous levels of adenosine during the ischemic interval. Although significant improvement was detected with pentostatin, the improvement was modest compared to controls, suggesting that the utility of inhibiting adenosine deaminase to modify regional mechanical stunning is limited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789447
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  • 7
    Electronic Resource
    Electronic Resource
    Water-Soluble imide-amide copolymers. III. Preparation and characterization of poly (acrylamide-co-N,N-diallylaniline) and poly (acrylamide-co-sodium N,N-diallylsulfanilate)Presented at the 72nd Canadian Chemical Conference, Victoria, British Columbia, June 4-8, 1989.Dedicated to the memory of W. M. Leung (1990)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 28 (1990), S. 2983-2996 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: N,N-diallylaniline monomer was prepared in good yields, for use in preparation of homopolymer and for copolymerization with acrylamide. Functionalized N,N-diallylaniline monomer, as sodium N,N-diallylsulfanilate, was also prepared in good yields for copolymerization with acrylamide. Both monomers were fully characterized by elemental analysis, IR, and NMR. Poly (N,N-diallylaniline) was obtained by polymerization of a strongly acidic aqueous solution of N,N-diallylaniline initiated with hydrogen peroxide. Spectroscopic data from this homopolymer was used to facilitate spectral assignments of the new copolymers. Copolymers of acrylamide with N,N-diallylamine were prepared at monomer feed ratios of 10, 20, and 30 mol % amine and gave 3.5, 7.4, and 8.9 mol % incorporation, respectively. Similar diallyl monomer incorporation rates were obtained for the copolymerization of sodium N,N-diallylsulfanilate with acrylamide. With 10, 30, and 50 mol % of the sodium salt relative to acrylamide, 3.9, 8.4, and 19.2 mol % incorporation of the diallyl monomer was obtained.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1990.080281108
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  • 8
    Electronic Resource
    Electronic Resource
    Friedel-Crafts polymerizations. III. Polymerization of carbazole and N-alkyl derivatives with chloromethyl methyl ether/aluminum chloride (1986)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 24 (1986), S. 233-239 
    Details
    ISSN: 0887-6258
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1986.140240508
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  • 9
    Electronic Resource
    Electronic Resource
    Polymers containing polynuclear aromatics linked by one-carbon bridges (1992)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 30 (1992), S. 2037-2044 
    Details
    ISSN: 0887-624X
    Keywords: Friedel-Crafts polymerization ; poly(arylene methylene)s ; synthesis ; polymers of naphthalene ; anthracene ; phenanthrene ; IR ; 1H and 13C-NMR ; soluble ; insoluble ; thermal stability ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The conversion of naphthalene, anthracene, and phenanthrene to polymeric material via Friedel-Crafts chemistry was investigated. Synthesis of the polymers was accomplished by: (1) self-condensation of the chloromethylated aromatic substrate in the presence of AlCl3 or SnCl4 or (2) treatment with chloromethyl ethyl ether (CMEE) and SnCl4, producing the chloromethylated substrate in situ, followed by self-condensation polymerization. Soluble or insoluble polymers were preferentially produced by varying the stoichiometry, time, or temperature of the reaction. The resulting polymers consisted of the polycyclic aromatic nuclei bridged by methylene groups. The regiochemistry of the polymer linkages was determined through the use of IR, 1H- and 13C-NMR. The polymers showed relatively high thermal and thermo-oxidative stabilities (380-495°C). © 1992 John Wiley & Sons, Inc.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1992.080300930
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  • 10
    Electronic Resource
    Electronic Resource
    Water-Soluble imide-amide copolymers. I. Preparation and characterization of poly [acrylamide-co-sodium N-(4-sulfophenyl) maleimide]Presented at the 72nd Canadian Chemical Conference, Victoria, British Columbia, June 4-8, 1989.Dedicated to the memory of Dr. W. M. Leung (1990)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 28 (1990), S. 2949-2968 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Sodium N-(4-sulfophenyl) maleimide (SPMI) and its saturated succinimide counterpart were first prepared according to established methods. Hydrolysis experiments on these monomers monitored by 1H-NMR showed that although SPMI monomer was about 15% hydrolyzed in D2O at 23°C in 24 h. Sodium N-(4-sulfophenyl) succinimide, which is similar in structure to the imide units in the copolymers, was only 1% hydrolyzed after 18 days at 23°C and 29% hydrolyzed after 18 days at 60°C. This indicated that the saturated imide rings in the copolymer might be sufficiently stable to hydrolysis for the copolymers to be useful. However, hydrolysis at high pH demonstrated that the imide rings would be rapidly saponified under alkaline conditions, destroying the structural rigidity that the intact rings might have provided in the copolymer chains. Sodium N-(4-sulfophenyl) maleimide (SPMI) was copolymerized with acrylamide in water at 30°C without cleavage of the imide ring. Water-soluble poly [acrylamide-co-sodium-N-(4-sulfophenyl) maleimide] (PAMSM) samples containing from 7.4 to 64 mol % imide were prepared. Photoacoustic FTIR and 13C-NMR spectra were used to confirm the structure of the copolymers obtained. Elemental analysis was used to determine the imide content of the copolymers, and from this composition data reactivity ratios were calculated for the two component monomers.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1990.080281106
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