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  • Adenosine deaminase  (2)
  • Mammals  (2)
  • Syzygies  (2)
  • 1
    Electronic Resource
    Electronic Resource
    On an implementation of standard bases and syzygies in SINGULAR (1996)
    Springer
    Applicable algebra in engineering, communication and computing 7 (1996), S. 235-249 
    Details
    ISSN: 1432-0622
    Keywords: Standard bases ; Syzygies ; Computer algebra system ; Highest corner ; EcartMethod
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics , Technology
    Notes: Abstract We describe an implementation of a general standard basis algorithm, valid for any monomial ordering compatible with the natural semigroup structure. We concentrate on new strategies which have proved useful, in particular in the non-wellordering case. Moreover, we describe the first implementation of Schreyer's method to compute syzygies and compare it with other, more classical methods. Comparisons of the computing time of several examples in the system SINGULAR give hints as to which strategies should be used in different classes of examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01190332
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    On an Implementation of Standard Bases and Syzygies in SINGULAR (1996)
    Springer
    Applicable algebra in engineering, communication and computing 7 (1996), S. 235-249 
    Details
    ISSN: 1432-0622
    Keywords: Key words Standard bases ; Syzygies ; Computer algebra system ; Highest corner ; EcartMethod.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics , Technology
    Notes: Abstract  We describe an implementation of a general standard basis algorithm, valid for any monomial ordering compatible with the natural semigroup structure. We concentrate on new strategies which have proved useful, in particular in the non-wellordering case. Moreover, we describe the first implementation of Schreyer’s method to compute syzygies and compare it with other, more classical methods. Comparisons of the computing time of several examples in the system SINGULAR give hints as to which strategies should be used in different classes of examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01190332
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure of ureteric innervation (1975)
    Springer
    Cell & tissue research 160 (1975), S. 515-524 
    Details
    ISSN: 1432-0878
    Keywords: Ureteric innervation ; Mammals ; Interspecies differences ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution and structure of the ureteric nerves in a small series of mammals was compared with that previously demonstrated in the rat. There was marked interspecies variation in the extent to which the nerves penetrated the wall of the ureter and in the degree of development of the deep submucous plexus. In animals with a highly developed deep submucous plexus, terminal arterioles frequently passed through the muscle coat before breaking up into capillaries. These vessels were surrounded by a fine periarteriolar plexus and were accompanied in their course through the muscle coat by one or more branches of the adventitial nerves. Intramuscular nerves not related to arterioles contained few axons with terminals classifiable as either adrenergic or cholinergic, and in animals in which the muscle cells were arranged in fascicles rather than in sheets, the nerves were typically interfascicular in position. As in the rat, only the periarteriolar plexuses contained large numbers of adrenergic axons. Cholinergic axons were generally few, but were not uncommon in the deep submucous plexus when this was well-developed. The majority of the terminals encountered in the intramural nerves contained variable and usually small numbers of both clear and large dense-cored vesicles. The relationship between these terminals and those defined in the submucous nerves of the rat ureter was discussed and it was suggested that the marked variations in the diameter of the axons in the terminal areas and in the number of vesicles in the terminals were related to the effects of the mechanical and other derangements which occur during processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225768
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure of the nerves innervating the muscle of the body of the bladder (1975)
    Springer
    Cell & tissue research 164 (1975), S. 133-144 
    Details
    ISSN: 1432-0878
    Keywords: Bladder body ; Mammals ; Musculature ; Innervation ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution and structure of the nerves supplying the muscle of the body of the bladder in mammals such as the mouse, guinea-pig, rabbit, cat and dog was compared with that previously demonstrated in the rat. The muscle of the arterioles located between the muscle bundles is innervated by a fine perivascular plexus and the nerves forming the muscular plexus can be divided into inter-and intra-fascicular components. Terminals containing variable but usually small numbers of clear and large dense-cored vesicles are particularly numerous in the interfascicular nerves and the intrafascicular nerves are characterised by large numbers of terminals with the features of those of cholinergic axons. In addition to many small clear vesicles, the cholinergic terminals contained some small dense-cored vesicles, and it is suggested that, as in the rat, these contain a second transmitter which is released with acetylcholine at the terminals during impulse transmission. Adrenergic terminals are more common in the muscular plexuses of the guinea-pig, dog and cat than in those of the other animals studied and there is evidence for the presence of two types of such terminal in the nerves. Of these, one contains a much smaller proportion of small vesicles with dense cores and many more large dense-cored vesicles than the second, and the possibility of a relationship between such terminals and those of short adrenergic neurones and neurones associated with non-adrenergic patterns of impulse transmission is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221700
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 240-251 
    Details
    ISSN: 1435-1803
    Keywords: Adenosine deaminase ; microdialysis ; micropig ; myocardial blood flow ; pentostatin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to examine the relationship between local adenosine concentrations before, during, and after ischemia and the extent of ischemic myocardial damage, measurements of interstitial fluid (ISF) nucleosides were made using microdialysis probes implanted in the ischemic region of isoflurane anesthetized Micropigs undergoing 60′ coronary artery occlusion (CAO) and 3h of reperfusion (REP). Nucleoside concentrations in the dialysate collected from the microdialysis probes were used as an index of ISF levels. Dialysate nucleoside concentrations (ADO, inosine and hypoxanthine), myocardial infarct size, and myocardial blood flow (MBF) were determined in control animals (n=6), animals preconditioned with a single 10′ cycle of CAO and REP (PC, n=6), and those treated with the adenosine deaminase inhibitor pentostatin (n=6, 0.2 mg/Kg IV 30′ prior to CAO). The brief PC occlusion resulted in a transient but significant increase in dialysate ADO (6.7±1.8 μM vs. 0.67±0.1 μM at baseline). Pentostatin administration had no significant effect on either dialysate nucleosides or MBF at baseline. During the 60′ CAO, dialystate ADO increased in control animals. In PC animals, however, dialysate ADO during CAO was lower than control. Pretreatment with pentostatin resulted in a six-fold augmentation in dialysate ADO during the 60 min CAO when compared to the control values (110.62±30.2 μM vs. 16.31±2.1 μM at 60 min of ischemia). Pentostatin also resulted in a significant reduction in the accumulation of inosine and hypoxanthine, indicating inhibition of adenosine deaminase activity. There were no significant differences in MBF between groups at any time point. Following 3 h REP, infarct size was 35.4±5.5%, 8.1±1.5% and 8.3±1.8% of the region at control, PC, and pentostatin groups, respectively. These data suggest that marked increase in ISF ADO during CAO, may be as effective in reducing INF as a modest increase in ISF ADO prior to prolonged CAO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788519
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of adenosine deaminase inhibition with pentostatin on myocardial stunning in dogs (1995)
    Springer
    Basic research in cardiology 90 (1995), S. 176-183 
    Details
    ISSN: 1435-1803
    Keywords: Adenosine deaminase ; adenosine ; myocardial stunning ; sonomicrometers ; microspheres ; dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study was to determine if adenosine deaminase inhibition with pentostatin could improve postischemic contractile dysfunction (stunning) in open-chest anesthetized dogs. All animals underwent 15 min of coronary occlusion followed by 3 h of reperfusion preceded by an intravenous bolus of either 0.2 mg/kg of pentostatin (n=8) or saline (n=7). Sonomicrometers were plced in the ischemic area and were used to measure systolic wall thickening before, during, and after occlusion of the left anterior descending artery. Myocardial blood flow was measured with tracer labeled microspheres at baseline, 10 min of occlusion and at 1 h of reperfusion. Both groups were equally dyskinetic during occlusion (−21±5% of baseline thickening in the controls and −28±8% in the pentostatin group). The pentostatin group, however, demonstrated better contractile function at all time points during reperfusion, which was significantly different from the control group at 3 h of reperfusion. The improvement in regional function in the pentostatin group was not due to significant disparities in hemodynamic variables, size of the region at risk, or in collateral blood flow. These results indicate that pentostatin can ameliorate the severity of myocardial stunning, an effect we propose is due to increasing endogenous levels of adenosine during the ischemic interval. Although significant improvement was detected with pentostatin, the improvement was modest compared to controls, suggesting that the utility of inhibiting adenosine deaminase to modify regional mechanical stunning is limited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789447
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    Paper (German National Licenses)
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