ISSN:
1434-0879
Keywords:
Alpha1-adrenoceptor
;
Age-related change
;
Rat prostate
;
Morphometry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The age-related changes in the density of alpha1-adrenoceptors in the dorsolateral lobe of the rat prostate were evaluated in Wistar rats at 8, 52, and 104 weeks of age. [3H]YM617, a newly senthesized alpha1-adrenergic blocker, was used as the ligand. The mean maximum number of binding sites, or alpha1-adrenoceptor density (Bmax)±SE of 104-week-old rats (11.0±1.2 fmol/mg protein) was significantly lower than that in the 8-week-old rats (37.0±4.3 fmol/mg protein) and 52-week-old rats (37.2±3.4 fmol/mg protein) respectively, P〈0.01. In contrast, mean affinity (Kd) values±SE of these groups showed no significant differences (8-week-old rats, 115.8±9.1; 52-week-old rats, 100.5±5.8; and 104-week-old rats, 116.4±9.8 pM). Mean volumes±SE of muscle cells of the prostate were 3.7±1.1x103 μm3 at 8 weeks, 30.0±6.2x103 μm3 at 52 weeks, and 18.6±8.2x103 μm3 at 104 weeks. Volumes for 8-week-old rats were significantly smaller than those for 52-week-old (P〈0.01) and 104-week-old rats (P〈0.05). However, the mean area density of the muscle cells showed no difference among the three groups: 20.1±2.2% at 8 weeks, 27.3±2.9% at 52 weeks and 20.3±3.4% at 104 weeks. In conclusion, the density of YM617-binding sites (alpha1-adrenoceptors) in 104-week-old rats was lower than in 8- and 52-week-old rats. Muscle volume in the rat prostate was larger in rats aged 52 and 104 weeks than in 8-week-old rats, but no correlation was found between alpha1-adrenoceptor density and the muscle volume or muscle density in aging.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00296882
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