ISSN:
1432-1440
Keywords:
Pancreatic cancer
;
Growth factor receptors
;
Growth factors
;
Adhesion molecules
;
Gene mutations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Molecular alterations play a key role in the pathogenesis of gastrointestinal cancers. In the present paper we describe relevant molecular alterations in human pancreatic adenocarcinomas. Overexpression of growth factor receptors (EGF receptor, c-erbB2, c-erbB3, TGFβ receptor I–III), growth factors (EGF, TGFα, TGFβ-1-3, aFGF, bFGF), adhesion molecules (ICAM-1, ELAM-1) and gene mutations (p53, K-ras, DCC, APC) are present in a significant number of these tumors. These changes stimulate tumor growth and enhance the metastatic behavior of pancreatic cancer cells and thereby may contribute to shorter postoperative survival following tumor resection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00202070
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