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  • Engineering General  (2)
  • Adriamycin  (1)
  • Biological weathering  (1)
  • Bone marrow transplant  (1)
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Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Narrowing the embryologic window of the adriamycin-induced fetal rat model of esophageal atresia and tracheoesophageal fistula (1996)
    Springer
    Pediatric surgery international 11 (1996), S. 444-447 
    Details
    ISSN: 1437-9813
    Keywords: Esophageal atresia ; Tracheoesophageal fistula ; Esophagus ; Rats ; Adriamycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We recently reported on a new fetal rat model of esophageal atresia (EA) with tracheoesophageal fistula (TEF) induced by prenatal exposure to adriamycin (1.75 mg/kg i. p. injected daily to the pregnant dam from the 6th to 9th gestational days). With this treatment regime, many fetuses were resorbed and the number of associated malformations was very high. The present study demonstrates that similar doses of the drug administered only on the 8th and 9th gestational days allow higher fetal survival (9.7 ∓ 3.9 vs. 6.8 ∓ 4.7 fetuses per litter, P 〈 0.01) with a similar incidence of EA-TEF (41.2% vs. 56.4%, n. s.) and decreased occurence of associated anorectal and genitourinary malformations. Since this model is an instrument for further investigation of the disturbed cellular and morphogenetic events leading to EA and TEF, the narrowing of the embryologic window obtained by the present study will allow better focusing of the research on the critical period of time involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180079
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Bone marrow transplant in a case of mucopolysaccharidosis I Scheie phenotype: skin ultrastructure before and after transplantation (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 33-38 
    Details
    ISSN: 1432-0533
    Keywords: MPS I-S ; Skin biopsy ; Ultrastructure ; Bone marrow transplant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An 11-year-old girl with mucopolysaccharidosis I Scheie phenotype (MPS I-S) received a bone marrow transplant (BMT) from her heterozygous HLA-identical LMC-non-reactive mother. Multidisciplinary studies were carried out and results evaluated 21 months after transplantation. Herein we report the ultrastructural findings pre-and post-BMT in skin. Multidisciplinary studies are commonly used to evaluate the benefits of metabolic correction following BMT in some MPS and other inherited metabolic disorders, and changes in morphology have been described in liver and few other tissues. In this case, we elected skin, since connective tissue is universally involved in MPS and is safely and easily obtainable. Comparison of skin biopsy specimens taken before and after BMT showed a considerable change in dermal fibroblast morphology, with marked reduction in cell size and the number and size of abnormal lysosomes, thus indicating the clearance of storage. Our results demonstrate that dermal cells respond to enzyme replacement therapy in MPS I-S, with the clearance of glycosaminoglycan lysosomal accumulation in connective tissue fibroblasts, which had near-normal morphology 21 months after BMT. Therefore, the practice of skin biopsy after BMT in MPS and other metabolic disorders in which dermal cells are involved should be encouraged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310920
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Human impact in a tourist karstic cave (Aracena, Spain) (1997)
    Springer
    Environmental geology 31 (1997), S. 142-149 
    Details
    ISSN: 1432-0495
    Keywords: Key words Tourist cave ; Human impact ; Speleothem degradation ; Biological weathering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Human intrusion on the Cave of Marvels (southwestern Spain) has produced a series of effects on the water (fall in the level of the pools due to pumping from nearby wells), the air (increased temperature and CO2 concentration as well as decreased relative humidity) and the rock. In addition, plant colonization, favored by the lighting system, has irreversibly altered numerous speleothems. The processes of degradation are especially intense in the sectors with less air volume and limited ventilation. The analysis of the cave deposits by scanning electron microscopy and thin section analysis revealed that floral pollution constitutes one of the most aggressive agents against the calcite and aragonite precipitates, being responsible for biochemical and biophysical degradation of the first order.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002540050173
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Seismic earth thrust against massive building walls (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 13 (1989), S. 347-357 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: The problem of earth thrust for a massive building in a seismic environment is analysed. Intertial and kinematic soil-structure interactions are considered by modelling the soil and the structure together. The problem is solved in the frequency domain by using the computer code FLUSH. Results show that the horizontal component of the seismic earth thrust is much greater than that obtained when applying the Mononobe-Okabe theory. This study establishes a set of conclusicns and recommendations for both design and practical purposes, and proposes future lines of investigation.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610130402
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of adjoining structures on seismic response of tunnels (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 16 (1992), S. 797-814 
    Details
    ISSN: 0363-9061
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: In this paper the seismic behaviour of buried concrete tunnels is studied using the finite element method. The numerical tool employed is the well-known soil-structure interaction computer program FLUSH and thus analyses are carried out in the frequency domain. The seismic environment is supposed to consist of vertically propagating shear and compression waves that reproduce artificial accelerograms of a broad frequency content at selected control points. The effect of near or adjacent massive structures, such as those of nuclear power plants, is evaluated showing their influence on tunnel response. The results calculated for acceleration levels, internal structural loads, response spectra, etc., are analysed and compared either with those obtained from soil free-field response or with others computed using an alternative simplified methodology, providing useful information for preliminary design purposes.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nag.1610161103
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    Paper (German National Licenses)
    Fulltext
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