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  • 1
    Electronic Resource
    Electronic Resource
    Aneurysms of coronary arteries in a patient with adult polycystic kidney disease: arteriosclerosis or involvement by the primary disease? (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 150-152 
    Details
    ISSN: 1432-1440
    Keywords: Adult polycystic kidney disease ; Coronary vascular abnormalities ; Coronary artery aneurysms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adult polycystic kidney disease is frequently associated with gastrointestinal and cardiovascular abnormalities. These include hypertension, mitral valve prolapse, mild dilation of the aortic root, abdominal aneurysms, and predisposition to aortic, mitral, and tricuspidal valve regurgitation reminiscent of Marfan's syndrome. Although tho exact molecular mechanisms of adult polycystic kidney disease are not well established, a generalized defect of collagen structure is hypothesized. The most severe vascular problems, however, are typical intracranial aneurysms with a high incidence of subarachnoid hemorrhage and a high mortality rate. We report a case of dilated coronary arteries found incidentally in a patient with adult polycystic kidney disease and stress-induced angina pectoris. The typical angina pectoris of the patient is explained by left ventricular hypertrophy and coronary heart disease. Multiple liver cysts, mitral valve prolapse, and the coronary aneurysms in this patient with adult polycystic kidney disease appear to reflect the manifestation of a generalized connective tissue disorder in this syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179997
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of aldosterone on intralymphocytic sodium and potassium in patients with essential hypertension (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 71-76 
    Details
    ISSN: 1432-1440
    Keywords: Essential hypertension ; Lymphocytes ; Sodium ; Potassium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In vitro binding of aldosterone to mineralocorticoid receptors on human mononuclear leukocytes (HML) and its effects on the intracellular sodium and potassium concentrations of HML have already been described. In the present paper this easily accessible human cell model was investigated in 13 patients with essential hypertension. In only four patients sodium in HML without incubation was elevated compared with the range for normal persons. A decrease of intracellular sodium or potassium occurred during incubation without aldosterone (P〈0.02). The addition of 1.4 nM aldosterone did not prevent this loss of electrolytes as observed in normal persons. Plasma renin activity and aldosterone were not correlated with the electrolyte response and were within the normal limits. The number of mineralocorticoid receptors/cell were within or close to the normal range (n=9). The independence of intracellular electrolytes from aldosterone despite a normal number of mineralocorticoid receptors may reflect an impairment of the mineralocorticoid effector mechanism in the HML of patients with essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646846
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Rezeptor-Effektorbeziehungen für den Einfluß von Aldosteron auf mononukleäre Leukozyten: Validierung und Applikation auf verschiedene Störungen des Wasser- und Elektrolythaushaltes beim Menschen (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 1-5 
    Details
    ISSN: 1432-1440
    Keywords: Aldosterone ; Lymphocytes ; Electrolytes ; Volume
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mineralocorticoid receptors were found in cells from extrarenal tissues such as spleen, hippocampus, smooth muscle, heart, hypophysis and mammary gland. Recently, mineralocorticoid receptors and effects of aldosterone on intracellular sodium and potassium have been described for human mononuclear leukocytes (HML). Both intracellular sodium and potassium concentrations decreased when HML from normal subjects were incubated for 1 h in a medium without aldosterone. In the presence of 1.4 nM aldosterone this loss of intracellular sodium and potassium from HML was absent, with values similar to those found in freshly prepared cells before incubation. The clinical significance of this model was underlined by the demonstration of absent or a decreased number of mineralocorticoid receptors and the lack of electrolyte response to aldosterone in HML of patients with pseudohypoaldosteronism. For patients with primary and secondary aldosteronism a reduced number of mineralocorticoid receptors has been shown on HML, thus indicating a “down-regulation” in response to chronically elevated serum levels of aldosterone. Additionally, an abnormal effector mechanism could be demonstrated in HML from these patients. These studies are the first to demonstrate the significance of extrarenal, nonepithelial mineralocorticoid receptors and the related effector mechanism for different disorders of the water- and electrolyte-balance in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01736527
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    Paper (German National Licenses)
    Fulltext
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