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  • Advanced carcinoma  (1)
  • Embolization  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 10 (2000), S. 802-805 
    ISSN: 1432-1084
    Keywords: Key words: Gastrointestinal bleeding ; Embolization ; Interventional therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Retrospective evaluation of interventional embolization therapy in the treatment of gastrointestinal hemorrhage over a long-term observation period from 1989 to 1997. Included in the study were 35 patients (age range 18–89 years) with gastrointestinal bleeding (GI) referred for radiological intervention either primarily or following unsuccessful endoscopy or surgery. Sources of GI bleeding included gastric and duodenal ulcers (n = 7), diverticula (n = 3), erosion of the intestinal wall secondary to malignancy (n = 6), vascular malformations (n = 4), and hemorrhoids (n = 2), as well as from postoperative (n = 6), posttraumatic (n = 2), postinflammatory (n = 4) or unknown (n = 1) causes. Ethibloc (12 cases) or metal coils (14 cases) were predominantly used as embolisates. In addition, combinations of tissue adhesive and gelfoam particles and of coils and Ethibloc were used (six cases). Finally, polyvinyl alcohol particles, a coated stent, and an arterial wire dissection were utilized in one case each. Bleeding was stopped completely in 29 of 35 cases (83 %). In one case (3 %) the source of bleeding was recognized but the corresponding vessel could not be catheterized. In five other cases (14 %) there was partial success with reduced, though still persistent, bleeding. The rate of complications was 14 %, including four instances of intestinal ischemia with fatal outcome in the first years, and, later, one partial infarction of the spleen without serious consequences. Gastrointestinal hemorrhage can be controlled in a high percentage of patients, including the seriously ill and those who had previously undergone surgery, with the use of minimally invasive interventional techniques. The availability of minicoils instead of fluid embolization agents has reduced the risk of serious complications.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Fortgeschrittenes Zervixkarzinom ; Blutung ; Embolisationsbehandlung ; Key words Cervix uteri ; Advanced carcinoma ; Hemorrhage ; Embolization treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: Retrospective evaluation of percutaneous interventional treatment of locally advanced cervical carcinoma. Materials and methods: Since 1991, 13 patients with advanced tumor disease have been referred to our department for diagnosis and therapy of an acute blood loss. In all patients (age 40–88 years, mean 61 years) hemorrhage was detected by decrease in red blood cell count. In all cases patients suffered from locally advanced or recurrent disease after surgery and/or additional radio- or chemotherapy. Embolization was performed by transfemoral access using minicoils in most cases, liquid agents less often and a covered vascular stent in one patient. Results: The site of the hemorrhage or the blood pooling of the tumor could be seen in all cases angiographically. Twenty-seven treatment cycles (2.1 per patient) were performed at intervals of 3 days to 6 months. The maximum time of follow-up and additional treatments if necessary was 1 year. In 9 of 13 patients (69%) the bleeding could be stopped immediately with a single treatment or initial treatment via both iliac arteries. One patient (7,7%) died during therapy because of an uncontrollable bleeding and consecutive decrease in red blood cells count. The remaining three patients (23%) showed slight persistent or recurrent bleeding, which could be managed interventionally until the following episode. There were two complications (15%) during therapy, representing a coil misplacement and a coil wash-out, which both could be managed interventionally. Conclusion: Hemorrhage following locally advanced or recurrent cervical carcinoma can be stopped interventionally in about 70% of cases. Even in partial success it is possible to manage the acute life-threatening situation. Follow-up examinations of up to 1 year justify this therapeutic concept.
    Notes: Zusammenfassung Ziel der vorliegenden Arbeit war die retrospektive Auswertung und Darstellung der Bedeutung interventioneller Methoden in der Behandlung von Patienten mit lokal fortgeschittenem Zervixkarzinom. Seit 1991 wurden uns 13 Patientinnen mit fortgeschrittener Tumorerkrankung und akuten Blutungen zur radiologischen Evaluierung und ggf. Intervention vorgestellt. Bei allen Patienten in einem Alter zwischen 40 und 88 Jahren (Durchschnitt: 61 J.) waren Blutungen mit deutlichem Hb-Abfall bis hin zur vitalen Bedrohung aufgetreten. In allen Fällen handelte es sich um Karzinome der Zervix uteri im fortgeschrittenem Stadium oder um Rezidive nach initialer Operation mit begleitender Radio- bzw. Chemotherapie. Bei allen Patienten konnten die Blutungsareale oder das Pooling des Kontrastmittel im Tumor angiographisch lokalisiert werden. Insgesamt erfolgten 27 Embolisationstherapien (2,1 pro Patient) in Abständen von 3 Tagen bis zu 6 Monaten und maximal über einen zeitlichen Verlauf von über 1 Jahr. In 9 von 13 Fällen konnte durch eine solitäre Behandlung bzw. eine zweizeitige Therapie über beide Iliakalarterien die Blutung akut zum Stillstand gebracht werden (69%). Eine Patientin verstarb noch während der Embolisation infolge des Blutverlustes (7,7%). Die anderen 3 Patientinnen zeigten abgeschwächt persistierende oder frühzeitig rezidivierende Blutungen (23%). Als Embolisate wurden vorwiegend Spiralen, selten flüssige Embolisate und einmal ein ummantelter Stent verwendet. Periinterventionelle Komplikationen traten in zwei Fällen auf. Hier gelang es sowohl eine fehlplazierte Spirale, als auch eine Embolisatverschleppung interventionell zu bergen. In etwa 70% können Tumorblutungen bei Zervixkarzinomen interventionell beherrscht werden. Auch wenn nur ein Teilerfolg zu verzeichnen ist, kann zumindest die lebensbedrohliche Akutsituation meist abgewendet werden. Daß z.T. Verläufe über 1 Jahr ohne Möglichkeit einer weiteren kurativen Behandlung der Tumoren vorliegen, rechtfertigt unserer Meinung nach diesen Therapiansatz.
    Type of Medium: Electronic Resource
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