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  • pharmacokinetics  (5)
  • Metabolism  (2)
  • Adverse drug reactions  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The influence of age and multimorbidity on the pharmacokinetics and metabolism of spironolactone
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 3 (1984), S. 147-159 
    Details
    ISSN: 0167-4943
    Keywords: aging ; multimorbidity ; pharmacokinetics ; spironolactone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(84)90006-2
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and pharmacodynamics of furosemide in geriatric patients
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 5 (1986), S. 249-263 
    Details
    ISSN: 0167-4943
    Keywords: furosemide ; geriatric patients ; multiple diseases ; pharmacodynamics ; pharmacokinetics
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(86)90026-9
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical pharmacology in the elderly - an example of interdisciplinary cooperation between basic research and clinic
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 12 (1991), S. 321-328 
    Details
    ISSN: 0167-4943
    Keywords: Adverse drug reactions ; Geriatric patients ; Multimorbidity ; Pharmacokinetics
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(91)90037-Q
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Pharmakokinetik von Spironolacton im Alter (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 909-910 
    Details
    ISSN: 1432-1440
    Keywords: Pharmacokinetics ; Spironolactone ; Canrenone ; Age ; Metabolism ; Pharmakokinetik ; Stoffwechsel ; Alter ; Spironolacton ; Canrenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 10 alten (77,2 Jahren) Patientinnen und 10 jungen (20,1 Jahren) weiblichen Probanden wurde die Pharmakokinetik von Canrenon nach mehrfacher täglicher oraler Gabe von 100 mg Spironolcaton unter den Bedingungen des steady-state untersucht. Die Konzentrationsbestimmungen erfolgten simultan mit einer spezifischen hochdruckflüssigkeits-chromatographischen und mit einer weniger spezifischen fluorimetrischen Methode. Maximale und mittlere Serumkonzentrationen von Canrenon waren bei den älteren Patientinnen etwa doppelt so hoch wie bei den jungen Versuchspersonen. Dies war die Folge einer verminderten Eliminationskapazität für Spironolacton bei den alten Patientinnen. Dabei war der Anteil von fluorogenen Metaboliten zu Carenon bei den alten Patientinnen höher als bei den jungen Probanden, so daß offenbar auch Verschiebungen in den Stoffwechselwegen von Spironolacton im Alter auftreten.
    Notes: Summary The pharmacokinetics of canrenone were compared in 10 elderly (77.2 years) patients and 10 young (20.1 years) female persons after multiple oral dosing of 100 mg Spironolactone during steady-state. The concentrations were determined using both a specific HPLC-assay and a nonspecific fluorometric assay. Maximum as well as mean concentrations of canrenone in serum of the elderly subjects were approximately twice as high as those in the young. This was the consequence of an impaired capacity for elimination of spironolactone in the elderly subject. In addition the ratio of the other fluorigenic metabolites and of canrenone were higher in the elderly. Thus also shifts in the metabolic pathways of spironolactone occure with progressing age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721925
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  • 5
    Electronic Resource
    Electronic Resource
    The influence of hydrochlorothiazide on the pharmacokinetics of enalapril in elderly patients (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 173-177 
    Details
    ISSN: 1432-1041
    Keywords: Enalapril ; Hydrochlorothiazide ; pharmacokinetics ; renal impairment ; old patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a randomized, cross-over, single-dose study of 19 elderly hypertensive patients (aged 62–84 y, SBP 〉 160 mm Hg, DBP 〉 100 mm Hg, creatinine clearance 11–93 ml·min−1) we have studied the pharmacokinetics of the angiotensin converting enzyme (ACE) inhibitor enalapril after a single oral dose of either 10 mg enalapril or 10 mg enalapril + 25 mg hydrochlorothiazide. The pharmacokinetics of enalapril were unaffected by hydrochlorothiazide, but there was a significant reduction in renal clearance and a significant increase in AUC(0–24 h) of enalaprilat after hydrochlorothiazide, resulting in higher serum concentrations of the active drug. This was independent of the individual degree of renal impairment and might be due either to an initial reduction of GFR by hydrochlorothiazide or to interference with the tubular secretion of enalaprilat. The relationships between serum enalaprilat and serum ACE activity were similar after both treatments, both consistent with a value for Ki of enalaprilat of about 0.1 nmol·l−1. Thus, serum ACE activity was not affected by hydrochlorothiazide but completely reflected the pharmacokinetics of enalaprilat in both treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740666
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of age, frailty and liver function on the pharmacokinetics of brofaromine (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 387-391 
    Details
    ISSN: 1432-1041
    Keywords: Key words Liver function tests; elderly ; pharmacokinetics ; geriatrics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The pharmacokinetics of brofaromine, a selective inhibitor of monoamine oxidase A, was evaluated in 12 frail elderly patients (66–92 y) and 12 healthy volunteers (20–35 y). Methods: Quantitative liver function tests were performed to show whether brofaromine elimination in the elderly could be predicted from noninvasive assessment of CYP1A2 activity (caffeine clearance) or liver plasma flow (sorbitol clearance). Results: In the elderly the AUC of brofaromine was significantly increased (e.g. for the 75 mg dose 43.2 vs 19.9 μmol*h⋅l−1, clearance was reduced (5.0 vs. 11.8 l⋅h−1), the volume of distribution was smaller (130 vs. 230 l), and the half-life was slightly increased (19.0 vs. 14.2 h). No significant correlation was observed between hepatic plasma flow and brofaromine clearance (r = 0.41, P = 0.05), whereas CYP1A2 activity and brofaromine clearance were tightly correlated (r = 0.94, P 〈 0.0001). Conclusion: Caffeine clearance, a simple, noninvasive test of CYP1A2 activity, is predictive of brofaromine clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050037
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of age, frailty and liver function on the pharmacokinetics of brofaromine (1996)
    Springer
    European journal of clinical pharmacology 49 (1996), S. 387-391 
    Details
    ISSN: 1432-1041
    Keywords: Liver function tests ; elderly ; pharmacokinetics ; geriatrics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The pharmacokinetics of brofaromine, a selective inhibitor of monoamine oxidase A, was evaluated in 12 frail elderly patients (66–92 y) and 12 healthy volunteers (20–35 y). Methods: Quantitative liver function tests were performed to show whether brofaromine elimination in the elderly could be predicted from noninvasive assessment of CYP1A2 activity (caffeine clearance) or liver plasma flow (sorbitol clearance). Results: In the elderly the AUC of brofaromine was significantly increased (e.g. for the 75 mg dose 43.2 vs 19.9 μmol*h·l−1, clearance was reduced (5.0 vs. 11.8 l·h−1), the volume of distribution was smaller (130 vs. 230 l), and the half-life was slightly increased (19.0 vs. 14.2 h). No significant correlation was observed between hepatic plasma flow and brofaromine clearance (r=0.41, P=0.05), whereas CYP1A2 activity and brofaromine clearance were tightly correlated (r=0.94, P〈0.0001). Conclusion: Caffeine clearance, a simple, noninvasive test of CYP1A2 activity, is predictive of brofaromine clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203783
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  • 8
    Electronic Resource
    Electronic Resource
    Elimination von Desacetylcefotaxim bei geriatrischen Patienten mit Multimorbidität (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 1497-1500 
    Details
    ISSN: 1432-1440
    Keywords: Desacetyl cefotaxime ; Pharmacokinetics ; Metabolism ; Geriatric patients ; Multiple diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma concentrations of cefotaxime and desacetyl cefotaxime were determined by HPLC in geriatric patients with multiple diseases. Comparison with a younger control group of healthy volunteers showed a prolongation of half-life of CTX and dCTX in the older patients. A significant correlation between pharmacokinetic parameters of dCTX and other clinical and chemical parameters was found. Half-life of dCTX was positively correlated with age of the geriatric patients (P〈0.05). There was also a significant relationship between CHE in serum and plasma peak concentrations of dCTX. Time until reaching plasma peak concentrations correlated closely with total bilirubin (P〈0.01), CHE (P〈0.001), cholesterol (P〈0.01), and urea (P〈0.01). Accumulation of the pharmacologically active metabolite dCTX could not be excluded in one patient with kidney disease. In accordance with other investigators it is recommended to reduce the dose of cefotaxime in geriatric patients with kidney diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716101
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