ISSN:
1432-1920
Keywords:
Contrast media
;
neurotoxicity
;
chemotoxicity
;
osmolality
;
subarachnoid injection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Equimolar doses of iohexol and metrizamide (0.48 mmol/kg body weight = 185 mg I/kg), administered in solutions iso- and hyperosmolar to the CSF, were injected subarachnoidally into rabbits under pentobarbital anaesthesia. No excitative effects of iohexol were observed in the behaviour of the rabbits during a 3-h period immediately after the injection. Metrizamide caused significant, severe excitative effects, ranging from hyperexcitability to repeated generalized seizures. The frequency and severity of excitative effects were independent of the osmolality of the metrizamide solutions injected.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00339861
Permalink