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  • Age  (1)
  • Autonomic blockade  (1)
  • Digoxin intoxication  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmakokinetik von Triamteren bei Probanden und Patienten mit Leber- und Nierenfunktionsstörungen (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 883-891 
    Details
    ISSN: 1432-1440
    Keywords: Triamterene ; Pharmacokinetics ; Metabolism ; Bioavailability ; Determination ; Liver disease ; Renal disease ; Age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The knowledge about the pharmacokinetics of triamterene (TA) was limited until recently. The metabolic pathway of TA is the formation of p-hydroxytriamterene (OH-TA), which is subsequently conjugated with active sulfate to form p-hydroxytriamterene sulfuric acid ester (OH-TA-ester). The phase-II-metabolite is surprisingly pharmacologically active. TA and its metabolites were measured concomitantly by a specific and sensitive tlc-method. The i.v. kinetics of TA were determined after application of a newly developed lactic acid solution of the drug. Comparing these data with results after oral application of TA the bioavailability of TA was 52% and the extent of absorption 83%. The bioavailability of different dosage forms was correlated with in vitrotests. In liver disease the pharmacokinetics of TA are markedly altered. While in cirrhosis the hydroxylation of TA was decreased, the biliary excretion of this agent was strongly reduced in hepatitis. In renal disease the excretion of TA and OH-TA-ester was reduced proportional to the reduction of endogenous creatinine clearance. In older patients the elimination of TA was impaired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537528
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Massive digoxin intoxication in childhood (1978)
    Springer
    Intensive care medicine 4 (1978), S. 199-201 
    Details
    ISSN: 1432-1238
    Keywords: Digoxin intoxication ; Serum digoxin concentration ; Serum potassium level ; Diphenylhydantoin ; Atropine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a 10 year old boy 8 hours after taking about 16 mg β-acetyl-digoxin a maximum serum digoxin level of 31.8 ng/ml was measured radioimmunologically. This is the highest digitalis level in childhood described to date. The serum potassium level rose to 7.4 mmol/l. Complete atrio-ventricular block, and salves of ventricular premature beats were the most serious rhythm disturbances. The absence of life threatening rhythm disturbances is attributed to the early use of diphenylhydantoin in small frequent doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01902547
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of digoxin on sinus node function after pharmacologic autonomic blockade (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 523-527 
    Details
    ISSN: 1432-1440
    Keywords: Digoxin ; Sinus node function ; Autonomic blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of iv digoxin on normal sinus node function was studied after pharmacologic autonomic blockade (AB) in ten patients. Sinus cycle length (SCL), sinus node recovery time (SNRT) and sinoatrial conduction time (SACT) were determined before and after AB with propranolol (0.2 mg/kg body weight) and atropine sulfate (0.04 mg/kg body weight) iv, and 15 min, 30 min, and 45 min after 1 mg iv digoxin. AB resulted in a significant decrease (P〈0.01) in SCL (916±158 to 716±120 ms), in SNRT (1,229±221 to 871±190 ms), and in SACT (79±34 to 44±10 ms). Fifteen minutes after iv digoxin there was no significant change observed in SCL (716±120 to 708±92 ms), in SNRT (871±190 to 864±148 ms), or in SACT (44±10 to 46±15 ms). Similar results were obtained 30 min after digoxin administration. It is concluded that a single therapeutic dose of digoxin has no direct effect on electrophysiologic parameters of normal intrinsic sinus node function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488720
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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