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  • 1
    Electronic Resource
    Electronic Resource
    Low-pH association of proteins with the membranes of intact red blood cells. II. Studies of the mechanism
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 981 (1989), S. 61-68 
    Details
    ISSN: 0005-2736
    Keywords: CD4 ; Erythrocyte ; Glycophorin ; Membrane defect ; Membrane-protein interaction ; pH effect
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0005-2736(89)90082-5
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Low-pH association of proteins with the membranes of intact red blood cells. I. Exogenous glycophorin and the CD4 molecule
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 981 (1989), S. 51-60 
    Details
    ISSN: 0005-2736
    Keywords: CD4 ; Erythrocyte ; Flow cytometry ; Glycophorin ; Immunoelectron microscopy ; Membrane-protein interaction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0005-2736(89)90081-3
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tolbutamide does not alter insulin requirement in Type 1 (insulin-dependent) diabetes (1984)
    Springer
    Diabetologia 27 (1984), S. 8-12 
    Details
    ISSN: 1432-0428
    Keywords: Tolbutamide ; insulin ; euglycaemic glucose clamp ; β cell ; Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined whether tolbutamide has any acute or short-term effects on insulin action in Type 1 (insulin-dependent) diabetes. A euglycaemic glucose clamp was performed in seven Type 1 diabetic patients without clinical insulin resistance by infusing glucose at a constant rate of 0.01 mmol·kg-1·min-1 for 3 h together with a simultaneous insulin infusion using an ‘artificial pancreas’. The insulin infusion rate required to maintain blood glucose at 6.7 mmol/l at a set low glucose infusion rate provides an index of insulin action in vivo. The euglycaemic clamp was performed on 3 separate days in the same patient: (1) in the basal state; (2) during simultaneous intravenous tolbutamide infusion of 0.5 g/h, and (3) after treatment with 2.5 g tolbutamide/day for 6 days in addition to insulin. The insulin infusion rate needed to maintain the set blood glucose level did not differ significantly between the three experimental conditions (1.2±0.2 versus 1.3±0.3 versus 1.2±0.3 U/h). Plasma glucagon, growth hormone, non-esterified fatty acid and glycerol levels did not differ between control or sulphonylurea treatment studies. The results suggest that tolbutamide does not exert any acute or short-term effects on insulin action in vivo in Type 1 diabetes. Our results do not provide support for the idea that this agent is a clinically useful adjunct to insulin in such patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253493
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of insulin resistance during inhibition of endogenous insulin and glucagon secretion by somatostatin in non-obese subjects with impaired glucose tolerance (1981)
    Springer
    Diabetologia 21 (1981), S. 192-197 
    Details
    ISSN: 1432-0428
    Keywords: Insulin resistance ; somatostatin infusion ; C-peptide ; insulin ; pancreatic glucagon ; growth hormone ; non-esterified fatty acids ; impaired glucose tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin resistance was studied in seven non-obese male subjects with impaired glucose tolerance and four healthy, age and body-weight matched male control subjects by means of a continuous intravenous infusion of somatostatin, glucose and insulin over 150 min. Glucose tolerance was evaluated by means of a 2-h glucose infusion test. Endogenous insulin (C-peptide), growth hormone, and glucagon secretion were suppressed by somatostatin in both groups. Steady-state plasma insulin and glucose levels were achieved between 90–135 min. Since similar steady-state levels of exogenous insulin were achieved, the resulting steady-state plasma glucose level provided a direct estimate of the ability of insulin to dispose of the infused glucose. The glucose levels were higher in subjects with impaired glucose tolerance with values of 14.6 ± 1.8 mmol/1 compared with 5.1 ± 1.2 mmol/1 in control subjects (p 〈 0.01), thus indicating insulin resistance. There was a direct correlation between the steady-state plasma glucose level and glucose tolerance suggesting that the degree of glucose intolerance is proportional to the degree of insulin resistance. These results revealed that decreased insulin sensitivity is found in non-obese subjects with impaired glucose tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252653
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The prognostic value of age for patients with common epithelial ovarian cancer (1985)
    Springer
    Journal of cancer research and clinical oncology 109 (1985), S. 152-155 
    Details
    ISSN: 1432-1335
    Keywords: Ovarian cancer ; Prognostic factors ; Age ; Stage ; Grade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For 230 patients with common epithelial ovarian cancer, the prognostic impact of age was examined. Statistical analysis was done using proportional hazard models, 3- and 5-year survival rates and median survival of stratified groups, and the Kaplan-Meier mean. Taking the age-adjusted mortality into account, the prognosis of the older patients was significantly worse. This effect depended primarily on early mortality (survival time 〈2 months). A comparative analysis was made of the prognostic factors age, grade, and stage, taking into account the correlation between factors. This analysis showed that, for our series, age was of lesser prognostic significance than grading, and both of these were of much less prognostic importance than staging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391890
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    Paper (German National Licenses)
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