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  • 1
    Electronic Resource
    Electronic Resource
    Ability of 3-carboxysalsolinol to produce ethanol-like discrimination in rats (1980)
    Springer
    Psychopharmacology 68 (1980), S. 277-281 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Ethanol ; Apomorphine ; Salsolinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of the present study was to investigate the possible generalization to 3-carboxysalsolinol (3C-SAL) in a group of rats trained to discriminate a low dose of ethanol (200 mg/kg IP) from the nondrug condition and in another group trained to discriminate 0.16 mg/kg IP apomorphine (AP) from the nondrug condition using a drug discrimination paradigm. In test sessions, ED50 for ethanol was 52.0 mg/kg and ED50 for AP was 0.01 mg/kg. In the ethanol-trained rats, 1.8 mg/kg 3C-SAL produced drug responses. In the AP-trained rats, 200 mg/kg ethanol produced drug responses whereas 1.8 mg/kg 3C-SAL produced only a partial drug response. The results are in harmony with the hypothesis that salsolinol in the central nervous system of the rat may be responsible for the discriminability of ethanol. The possible involvement of dopaminergic systems is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428115
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction between discrimination of drug states and external stimuli (1979)
    Springer
    Psychopharmacology 61 (1979), S. 105-106 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; External stimuli ; Drug-induced stimulus control ; Discrimination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats learned a two-choice operant response by discriminating differences between external stimuli, internal (drug-produced) stimuli, or a combination of these two types of stimuli. Separate groups of rats were used for each stimulus condition. A tactile and visual external cue was superior to the ethanol-saline cue in producing stimulus control, but the group receiving both drug and external stimulus cues performed in a manner very similar to the external cue-only group. The two stimulus sources thus did not “add” to promote more rapid or complete discrimination. After acquisition of discrimination, previously coincident drug and external stimulus states were reversed to determine which stimulus source had more behavioral control. This test for stimulus selectivity indicated that the external stimulus had essentially complete control of response choice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426820
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  • 3
    Electronic Resource
    Electronic Resource
    Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats (1992)
    Springer
    Psychopharmacology 107 (1992), S. 564-568 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Conditioned place preference ; Locomotor activity ; HAS/LAS ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0–3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3–1.0 g/kg ethanol on spontaneous locomotor activity over a 30-min period, as well as the loss of righting reflex with a higher ethanol dose (3.0 g/kg), were determined in these animals. The LAS rats reacted more aversively to 1.0 g/kg during conditioned place aversion testing than the HAS animals and also had a shorter mean sleeping time following 3.0 g/kg ethanol. Furthermore, dose-related depression of spontaneous motor activity was seen in the HAS animals and not in the LAS animals over a 30-min period using doses of 0.3, 0.6, or 1.0 g/kg (10% w/v) ethanol. Taken together, the results indicate that the intoxicating sequelae of high ethanol doses, such as ataxia and sedation, may not be correlated with the aversive effects of low ethanol doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245271
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  • 4
    Electronic Resource
    Electronic Resource
    Das Lösungsmittel DimethylsulfoxidUnserem verehrten Lehrer, Herrn Professor Alfred Rieche, zum 65. Geburtstag gewidmet (1967)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 79 (1967), S. 340-357 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Das dipolare, aprotonische Lösungsmittel Dimethylsulfoxid verfügt über einen weiten Bereich des flüssigen Aggregatzustandes, hohe Elektronendonatorfähigkeit und Polarität. Darauf beruht sein ausgezeichnetes und selektives Lösungsvermögen für eine Vielzahl organischer, auch polymerer Verbindungen, die Fähigkeit zur H-Brückenbindung und Dipol-Dipol-Assoziation. Die Struktur des Dimethylsulfoxids mit einem „harten“ Sauerstoff- und einem „weichen“ Schwefelatom bewirkt eine gute Kationen- und eine schlechte Anionensolvatation. Mischungen von Alkoholaten mit Dimethylsulfoxid gehören daher zu den basischsten Systemen der organischen Chemie und sind hervorragend zur Deprotonierung schwach acider OH-, NH- und CH-Bindungen, zu Eliminierungen und zur Auslösung von Polymerisationsreaktionen geeignet.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19670790803
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  • 5
    Electronic Resource
    Electronic Resource
    Additionsreaktionen von Cyansäureestern (1965)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 77 (1965), S. 96-97 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19650770208
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  • 6
    Electronic Resource
    Electronic Resource
    Additionsreaktionen von Cyansäureestern (1965)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 77 (1965), S. 1033-1033 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19650772273
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  • 7
    Electronic Resource
    Electronic Resource
    Säure-katalysierte Oxidation von Isonitrilen durch Dimethylsulfoxid (1967)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 79 (1967), S. 145-145 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19670790304
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  • 8
    Electronic Resource
    Electronic Resource
    Cyansäurephenylester (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 303-303 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19640760709
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  • 9
    Electronic Resource
    Electronic Resource
    Synthese von Schwefelheterocyclen und deren Ringsprengung unter Bildung von Cyansäureestern (1965)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 77 (1965), S. 382-382 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19650770815
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  • 10
    Electronic Resource
    Electronic Resource
    Addition Reactions of Cyanic Esters (1965)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 4 (1965), S. 73-74 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196500732
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