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  • Polymer and Materials Science  (6)
  • Aging  (2)
  • Cytochromec oxidase  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8) (1995)
    Springer
    Acta neuropathologica 90 (1995), S. 626-632 
    Details
    ISSN: 1432-0533
    Keywords: Key words Monoamine oxidase-B ; Senescence-accelerated mouse (SAM) ; Monoamine ; oxidase-B-positive granular structure ; Periodic ; acid-Schiff-positive granular structure ; Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the histochemical localization of monoamine oxidase in the hippocampus of young and old senescence-accelerated mouse (SAM). We found a monoamine oxidase-B-positive granular structure (MGS) in the hippocampus of old SAMP8, an accelerated senescence-prone line of SAM. The MGS was a round-shaped granular structure of 0.5 to 5 μm diameter and usually formed a cluster, the largest diameter of which ranged from 50 to 150 μm. No MGS were found in the hippocampus of young SAMP8 or of young SAMR1, an accelerated senescence resistant line of SAM, and only few, if any, were seen in old SAMR1. A monoamine oxidase-positive astrocyte was usually observed in the central area of each cluster of MGS. Furthermore, the MGS was in close anatomical relationship with monoamine oxidase-positive astrocytic processes. The enzyme inhibition experiments showed that monoamine oxidase activities localized in the MGS and astrocytes were both predominantly of type B. These findings suggest MGS occurs at least partly in monoamine oxidase-B-positive astrocytes. Furthermore, the MGS was similar to a periodic acid-Schiff-positive granular structure, a polyglucosan body previously documented in the brains of old SAMP8 and some other aged mice strains including C57BL/6 and nude mice, in terms of their size, morphological appearances and topographical distribution in the hippocampus. Thus, the present results suggest that monoamine oxidase type B is a proteinaceous component of the periodic acid-Schiff-positive granular structure in aged mice brains, and might provide some clues for clarifying the mechanisms of age-related occurrence of periodic acid-Schiff-positive granular structures in mice brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318576
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  • 2
    Electronic Resource
    Electronic Resource
    In situ hybridization of muscle mitochondrial mRNA in mitochondrial myopathies (1990)
    Springer
    Acta neuropathologica 81 (1990), S. 1-6 
    Details
    ISSN: 1432-0533
    Keywords: In situ hybridization ; Mitochondrial DNA ; Mitochondrial myopathy ; Ophthalmoplegia ; Cytochromec oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine whether a mitochondrial mRNA deficiency exists in mitochondrial myopathies, muscle biopsies from a patient with chronic progressive external ophthalmoplegia (CPEO) and a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) were studied using in situ hybridization. Histochemistry and immunohistochemistry were performed along with hybridization. Hybridization reactions were widely distributed over the sarcoplasm of all muscle fibers in the patient with MELAS. In the patient with CPEO, 80% of the fibers showed a marked decrease in density of autoradiographic grains. This marked decrease corresponded to the histochemical and immunohistochemical findings of a very weak staining of cytochromec oxidase (CCO). The isotope-labeled cDNA probe used in in situ hybridization in this study complements a part of subunit I of CCO and a part of subunit II of complex I in the mitochondrial gene. Our results suggest a defect in the mRNA in this CPEO patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662630
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  • 3
    Electronic Resource
    Electronic Resource
    Decreased activity of cytochromec oxidase in the macular mottled mouse: an immuno-electron microscopic study (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 465-471 
    Details
    ISSN: 1432-0533
    Keywords: Menkes kinky hair syndrome ; Macular mottled mouse ; Mitochondrion ; Cytochromec oxidase ; Gold-labeling immuno-electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The macular mottled mouse is a murine model of the kinky hair syndrome, characterized by a deficiency in copper transport. Cytochromec oxidase (CCO), a respiratory enzyme, is located in the inner mitochondrial membrane and consists of seven subunits, along with copper and iron. Biochemical and histochemical findings indicated that CCO activity was decreased in the cerebellum of the macular mottled mice but not in that of the controls. Immunocytochemical analysis, using anti-CCO and anti-complex III rabbit sera, revealed that CCO in the macular mottled mice was stained more weakly than that in the controls. Immuno-electron microscopic examination of CCO and complex III, using a method of gold labeling, was also performed. In the control mice, a high concentration of gold particles present over CCO and complex III could be seen in the inner mitochondrial membrane. The number of CCO-labeled gold particles was remarkably less, however, in the macular mottled mice, while no significant difference was found in the labeling of complex III between the two groups. It may concluded that the very low CCO enzyme content in the macular mottled mouse results not only from a copper transport disorder but also from a CCO protein synthesis disorder which impairs the localization of CCO protein in the cerebellum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687247
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  • 4
    Electronic Resource
    Electronic Resource
    Mutations disturbing the condensation of plastid nucleoids inChlamydomonas reinhardtii (1994)
    Springer
    Protoplasma 178 (1994), S. 111-118 
    Details
    ISSN: 1615-6102
    Keywords: Aging ; Chlamydomonas ; Plastid nucleoid condensation ; Mutant ; Plastid nucleoids ; O2 evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary To study the mechanism of condensation of dispersed plastid (pt) nucleoids into a single pt nucleoid with aging of the cells ofChlamydomonas reinhardtii, two mutants, designated cond-1 and cond-2, were isolated. A plastid of a wild type cell, 6.5 μm in diameter, contained ten dispersed spherical pt nucleoids within one week of culture on an agar plate. At about one week of culture, the cell number was saturated and pt nucleoids began to associate with each other, condensing into a single pt nucleoid at three weeks of culture. In contrast, cond-1 and cond-2 cells, which had about 20 and 45 pt nucleoids and whose cell diameters were 7.8 and 9.5 μm at one week of culture respectively, still had about 10 and 20 pt nucleoids at even 7 weeks of culture. Doubling times of the three cell types were similar. From genetic analysis, each of the two mutants had one gene mutation. The two mutations are probably linked. The measurement of O2 evolution showed that the two mutations did not affect the photosynthetic system. Lipid contents of the two mutant cells were clearly higher than that of wild type cells. The role of a higher number of pt nucleoids is probably to increase the activity of lipid and/or membrane synthesis for lipid storage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01545961
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis of copolyester having quaternary ammonium groups in the main chain (1996)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 34 (1996), S. 2517-2519 
    Details
    ISSN: 0887-624X
    Keywords: functional polyester ; liquid/solid biphase polycondensation ; tertiary amine group ; heterogeneous polymer reaction ; quaternary ammonium group ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 6
    Electronic Resource
    Electronic Resource
    Chemoselective polycondensation of isophthaloyl chloride with multifunctional monomers containing hydroxyl groups and sulfamino acid or amino acid moiety (1996)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 34 (1996), S. 493-495 
    Details
    ISSN: 0887-624X
    Keywords: chemoselective polycondensation ; functional polymer ; aromatic polyester ; hydroxyl group ; sulfamino acid moiety ; amino acid moiety ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: No abstract.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Factors affecting dynamic durability of polycarbonate under bending, torsional, and impacting fatigue and in cavitation erosion and dynamic solvent cracking conditions (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 20 (1976), S. 79-92 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: To understand influences of various factors on dynamic durability of engineering plastics, effects of average molecular weights of samples, molding variables, preparing methods of specimens, and fillers on plane and rotational bending, torsional, and impacting fatigue and cavitation erosion and solvent cracking of polycarbonate were studied. From the experimental results, the following tendencies are observed as a whole in case of polycarbonate: The extent of influence of the factors on dynamic durability varies depending on the type of testing. Increase in molecular weight has a favorable effect on dynamic durabilities. Influence of molding conditions is remarkable: especially, deficient drying of resin pellets before molding decreases dynamic durability noticeably, and specimens prepared by injection molding have much better durabilities than those by machaning from extruded sheet. Polyethylene blending has an unfavorable effect on durability, except for Izod-type impact strength and solvent cracking. Reinforcement by glass fiber has a favorable effect on fatigue under constant deformation and cavitation erosion.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1976.070200108
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  • 8
    Electronic Resource
    Electronic Resource
    Infrared spectroscopic studies of polymer transitions. III. Effects of sodium ion of glass transitions in styrene-based ionomers (1974)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 12 (1974), S. 633-633 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1974.180120315
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  • 9
    Electronic Resource
    Electronic Resource
    Low-temperature dielectric relaxation in poly(4,4′-oxydiphenylene pyromellitimide) (1984)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 22 (1984), S. 1399-1405 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The effect of end groups on the low-temperature dielectric relaxation in poly(4,4′-oxydiphenylene pyromellitimide) has been studied using three kinds of samples with different content of anhydride end groups. The magnitude of the dielectric loss peak, designated here the V peak, which appears near -40°C at 1 kHz, depends on the content of anhydride end groups. If a sample with few anhydride end groups is allowed to absorb water, a loss peak appears near the temperature region of the V peak, but it disappears after subsequent heating. In contrast, a sample having a larger amount of anhydride end groups exhibits a large V peak which remains even after further heating. We conclude that the —O—portion of the anhydride end groups is responsible for the V peak, though there may be an additional contribution from absorbed water.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1984.180220804
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  • 10
    Electronic Resource
    Electronic Resource
    Physical properties and structure of silk. VIII. Effect of casting temperature on conformation of wild silk fibroin films (1985)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 23 (1985), S. 227-229 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1985.180230120
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