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  • Agrobacterium tumefaciens  (4)
  • Depression  (4)
  • signal transduction  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Validez convergente de la version Espanola preliminar del child abuse potential inventory: Depresion y ajuste marital
    Amsterdam : Elsevier
    Child Abuse & Neglect 16 (1992), S. 119-126 
    Details
    ISSN: 0145-2134
    Keywords: Child abuse ; Depression ; Marital adjustment ; Prediction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0145-2134(92)90012-G
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neutrophil β2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls (1999)
    Springer
    Psychopharmacology 143 (1999), S. 131-140 
    Details
    ISSN: 1432-2072
    Keywords: Key words Post-traumatic stress disorder ; Beta2-adrenergic receptor ; G protein ; Coupling ; Anxiety ; Depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The symptomatology of post-traumatic stress disorder (PTSD) involves sympathetic hyperarousal. Several of these sympathetic symptoms are mediated through end-organ beta2-adrenergic receptors (β2AR). Increased sympathetic activity in PTSD could therefore be due to increased βAR function. This study investigated βAR function in 30 healthy controls and 20 drug-free PTSD patients. βAR binding studies were conducted using antagonist-saturation and agonist-displacement experiments. Measures of β2AR coupling to Gs protein were derived from agonist-displacement experiments. PTSD patients had significantly higher β2AR density – particularly in the high-conformational state – and higher β2AR coupling than controls, as reflected in a higher percentage of receptors in the high conformational state and a higher ratio of the agonist dissociaton constant from the receptor in the low-/high-conformational state. Increased βAR function in PTSD is consistent with the symptomatology of this disorder. Increased βAR density and coupling may be consistent with downregulation of βAR density and uncoupling by antidepressants and may underlie their partial efficacy in PTSD. Dysregulation in Gs protein function is postulated and, agonist-mediated regulation of βAR expression and/or βAR kinase activity in PTSD should be investigated in future studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050928
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Platelet α2-adrenergic receptor coupling efficiency to Gi protein in subjects with post-traumatic stress disorder and normal controls (1999)
    Springer
    Psychopharmacology 141 (1999), S. 258-266 
    Details
    ISSN: 1432-2072
    Keywords: Key wordsα2-Adrenergic receptor ; G protein ; Coupling ; Post-traumatic stress disorder ; Anxiety ; Depression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Low platelet membrane α2-adrenergic receptor (α2AR) density and low basal and forskolin-stimulated cyclic adenosine monophosphate responses, which have been reported in post-traumatic stress disorder (PTSD), suggest either abnormal α2AR coupling to Gi protein or dysregulation in post-receptor signal transduction mechanisms. α2AR density in the high- and low-conformational states, agonist affinity in both states and coupling to Gi protein were investigated in 23 drug-free combat PTSD patients and 25 normal controls. α2AR coupling measures were not different between PTSD patients and controls. Total α2AR density was higher in PTSD patients than controls, due to a higher density of the receptor in the high-conformational state. There were no differences in agonist affinity to the receptor in either conformational state. Results rule out dysregulation in α2AR coupling to Gi protein. Studies of post-receptor signal transduction mechanisms are warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050833
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  • 4
    Electronic Resource
    Electronic Resource
    Localization of the VirA domain involved in acetosyringone-mediatedvir gene induction inAgrobacterium tumefaciens (1994)
    Springer
    Plant molecular biology 25 (1994), S. 899-907 
    Details
    ISSN: 1573-5028
    Keywords: Agrobacterium ; gene regulation ; sensor protein ; signal transduction ; VirA protein ; acetosyringone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The VirA protein ofAgrobacterium tumefaciens is thought to be a receptor for plant phenolic compounds such as acetosyringone. Although it is not known whether the interaction between VirA and the phenolics is direct or requires other phenolic-binding proteins, it is shown in this study that the first 280 amino acids of the VirA protein are not essential for the acetosyringone mediatedvir gene induction response. Considering the fact that the cytoplasmic region between the amino acids 283 and 304 is highly conserved between the different VirA proteins, and that deletion of this region abolishes VirA activity, we suggest that the acetosyringone receptor domain is located in this cytoplasmic domain of the VirA protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00028884
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Octopine and nopaline strains of Agrobacterium tumefaciens differ in virulence; molecular characterization of the virF locus (1990)
    Springer
    Plant molecular biology 14 (1990), S. 249-259 
    Details
    ISSN: 1573-5028
    Keywords: Agrobacterium tumefaciens ; virulence gene ; host range ; plant tumour induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Octopine and nopaline strains of Agrobacterium tumefaciens were found to differ in virulence on Nicotiana glauca. This difference is due to the absence of a functional virF locus, which is necessary for efficient tumorigenesis on N. glauca, from the nopaline Ti plasmids. Genetic studies and DNA sequence analysis of the virF locus revealed that virF embraces one open reading frame coding for a hydrophilic protein with a molecular mass of 22437 Da. Transcription of virF is directed from left to right, towards the T region, and is strongly induced by the phenolic compound acetosyringone. We established that virA and virG, two genes known to be essential for induction of the vir regulon, are necessary for acetosyringoneinduced virF expression, implying that virF is a member of this vir regulon. Agrobacterium virF mutants can be complemented for tumor induction by co-infection with avirulent Agrobacterium ‘helper’ strains. We found that such ‘helper’ strains must express not only the virF gene but also the vir operons virA, virB, virD and virG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00018565
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular cloning and biochemical characterization of a receptor-like serine/threonine kinase from rice (1994)
    Springer
    Plant molecular biology 26 (1994), S. 791-803 
    Details
    ISSN: 1573-5028
    Keywords: ATP ; GTP ; protein kinase ; receptor ; rice ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A receptor-like protein kinase, OsPK10, has been cloned from rice (Oryza sativa). The 2.8 kb cDNA contains an open reading frame capable of encoding a peptide sequence of 824 amino acids. The topological features of the predicted OsPK10 protein include an N-terminal signal peptide, a cysteine-rich extracellular ligand-binding domain, a membrane-spanning segment, and a cytoplasmic domain possessing all the hallmarks of catalytic domains of eukaryotic protein kinases. The cytoplasmic domain was selectively expressed in Escherichia coli and assayed for kinase activity. The results show the protein is capable of autophosphorylation using either ATP or GTP as the phosphate donor. Phosphoamino acid analysis reveals phosphorylation of threonines, consistent with the substrate specificity indicated by sequence motifs in the catalytic core. A single amino acid substitution of Glu for Lys-528 completely abolishes autophosphorylation activity. DNA gel blot analyses suggest that the haploid rice genome contains a single copy of the OsPK10 gene. OsPK10 transcripts appear to be more abundant in shoots than in roots of rice seedlings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00028849
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Deviating T-DNA transfer fromAgrobacterium tumefaciens to plants (1996)
    Springer
    Plant molecular biology 31 (1996), S. 677-681 
    Details
    ISSN: 1573-5028
    Keywords: Agrobacterium tumefaciens ; Arabidopsis thaliana ; T-DNA transfer ; transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We analyzed 29 T-DNA inserts in transgenicArabidopsis thaliana plants for the junction of the right border sequences and the flanking plant DNA. DNA sequencing showed that in most lines the right border sequences transferred had been preserved during integration, corroborating literature data. Surprisingly, in four independent transgenic lines a complete right border repeat was present followed by binary vector sequences. Cloning of two of these T-DNA inserts by plasmid rescue showed that in these lines the transferred DNA consisted of the complete binary vector sequences in addition to the T-region. On the basis of the structure of the transferred DNA we propose that in these lines T-DNA transfer started at the left-border repeat, continued through the vector part, passed the right border repeat, and ended only after reaching again this left-border repeat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00042239
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  • 8
    Electronic Resource
    Electronic Resource
    Studies on the structure of cointegrates between octopine and nopaline Ti-plasmids and their tumour-inducing properties (1982)
    Springer
    Plant molecular biology 1 (1982), S. 265-276 
    Details
    ISSN: 1573-5028
    Keywords: Southern hybridizations ; crown gall ; Nicotiana tabacum ; Agrobacterium tumefaciens ; Ti-plasmids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Stable cointegrates between incRh-1 octopine (Ach5) and nopaline (C58) Ti-plasmids, present in ten independently isolated Agrobacterium tumefaciens strains, showed identical restriction endonuclease patterns. Each cointegration event had taken place in the common sequence between the T-regions of both Ti-plasmids. This illustrates a high preference for this region when used in the formation of cointegrates. Four crown gall tissues, obtained after transformation of Nicotiana tabacum cells by one of the mutants, were analysed by using Southern blot analysis for their T-DNA structure. The borders of T-DNA frequently appeared to differ from T-DNA borders previously detected in tumour tissues that had been induced by Agrobacterium strain C58 or Ach5. Therefore, it was concluded that possibly a less stringent mechanism exists for the integration into plant DNA of T-DNA, derived from a composite (octopine/nopaline) T-region than for integration of T-DNA from a normal (octopine or nopaline) T-region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00027558
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Molecular identification of a soybean protein kinase gene family by using PCR (1992)
    Springer
    Plant molecular biology 18 (1992), S. 581-584 
    Details
    ISSN: 1573-5028
    Keywords: gene family ; polymerase chain reaction ; protein kinases ; signal transduction ; soybean (Glycine max L.)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In this study we report identification of six members of a protein kinase gene family from soybean (Glycine max L.). Two fully degenerate oligonucleotide primers corresponding to two conserved motifs (DLK-PENV and GTHEYLAPE) in the catalytic domains of eukaryotic protein serine/threonine kinases were used in a polymerase chain reaction (PCR) to amplify soybean cDNA. Sequence analysis showed that 28 of the PCR sequences represented six different putative protein serine/threonine kinases. These results not only demonstrate that catalytic domains of protein kinases are highly conserved between plants and other eukaryotes but also suggest that there are multiple genes encoding protein kinases in plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00040673
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  • 10
    Electronic Resource
    Electronic Resource
    Agrobacterium and plant genetic engineering (1992)
    Springer
    Plant molecular biology 19 (1992), S. 15-38 
    Details
    ISSN: 1573-5028
    Keywords: Agrobacterium tumefaciens ; plant transformation ; plant tumours ; T-DNA ; Ti plasmid ; transgenic plants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00015604
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    Paper (German National Licenses)
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