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  • 1
    ISSN: 1432-1440
    Keywords: Synovial fluid ; IL-6 ; Cytoskeleton ; Antibodies ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Synovial fluids and sera from patients with rheumatoid arthritis, psoriatic arthritis, yersinia arthritis, Behçet's syndrome, Crohn's disease, and osteoarthritis were tested for antinuclear antibodies and antibodies to five cytoskeletal components in sensitive enzyme-linked immunosorbent assay (ELISA) systems and for IL-6 concentrations in a proliferation assay (IL-6 dependent hybridoma cell line B13.29, subclone B9). Statistically significant correlations between antibody activities and IL-6 levels were found for vimentin antibodies (r= 0.56; p〈0.05) and actin antibodies (r= 0.44;p〈0.05). In patients with chronic and active disease like rheumatoid arthritis and psoriatic arthritis, optical densities measured by vimentin- and actin-ELISA were significantly different from those measured in patients with osteoarthritis. To date only a few reports exist concerning the incidence of antibodies in synovial fluids. We have shown to our knowledge for the first time that IL-6 seems to induce synovial fluid antibody activities restricted to cytoskeletal components of synoviocytes (i.e., vimentin and actin). Synovial fluid antibody activities against vimentin and actin appear to be markers of activity in patients with inflammatory joint disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 337 (1974), S. 235-243 
    ISSN: 1435-2451
    Keywords: Acute Hepatic Failure ; Symptomatic Therapy ; Causal Therapy ; Akute Leberinsuffizienz ; Symptomatische Therapie ; Kausale Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Leberversagen kann als partielle und globale Insuffizienz auftreten. Die Therapie der akuten Leberinsuffizienz richtet eich nach Ätiologie und Verlauf. Als symptomatische Behandlung stehen im Vordergrund: Senkung des Blutammoniums, Beeinflussung von Störungen im Elektrolyt- und Wasserhaushalt, Ausgleich von Koagulationsstörungen, Überwachung der respiratorischen und zirkulatorischen Homoiostase. Die Frage, was kann für die Leber selbst getan werden, wird anhand der heute eingesetzten Verfahren besprochen. Weder Corticosteroidbehandlungen noch Austauschtransfusionen haben sichere Erfolge gebracht. Große Probleme sind z. Z. noch mit dem temporären Leberersatz sowie der heterotopen und orthotopen Lebertransplantation verbunden. Prospektive Studien zur Klärung einer Effektivität von Cortison und/oder Anti-HBAg-Plasma sind nicht abgeschlossen.
    Notes: Summary Hepatic failure can be divided into two main types, (1) partial and (2) total insufficiency. The treatment of acute hepatic failure depends on the etiology and course of the illness. Symptomatic therapy is concentrated on hyperammoniaemia, water and electrolyte metabolism, impaired coagulation, and homeostasis of the respiratory tract and of the circulation. Possible ways of improving liver regeneration have been discussed exhaustively; corticosteroids and exchange transfusion have not proved as effective as expected. The temporary substitution of the liver and heterotopic and orthotopic liver transplantation remain major problems. Controlled trials on the effectivity of high dosages of corticosteroids and/or anti-HBAg immunoglobulin are in progress.
    Type of Medium: Electronic Resource
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