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  • Albumin  (1)
  • Autoradiography  (1)
  • CDR1  (1)
  • Chemistry  (1)
  • Chordoma  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Synergistic effect of ofloxacin and fluconazole against azole-resistant Candida albicans (2000)
    Springer
    Journal of infection and chemotherapy 6 (2000), S. 151-154 
    Details
    ISSN: 1437-7780
    Schlagwort(e): Key words Ofloxacin ; Fluconazole ; CDR1 ; Candida albicans ; Rhodamine 6G
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We investigated the combination effects of ofloxacin and fluconazole against azole-resistant Candida albicans strains in vitro and in vivo. Ofloxacin alone showed no efficacy against the azole-resistant C. albicans strain, C26. The in-vitro combination effects were evaluated by the checkerboard method, calculated as the fractional inhibitory concentration (FIC) index, but there was no synergistic effect of the combination. The activity of the drug efflux pump in the azole-resistant C. albicans strains was measured by intracellular rhodamine 6G concentration. When the cells were incubated with ofloxacin or grepafloxacin, the intracellular rhodamine 6G concentration was significantly increased in the azole-resistant C. albicans strain. In-vivo combination effects were evaluated in murine disseminated candidiasis. The survival of the mice was not prolonged, but counts of the yeast cells in the kidney and spleen were reduced following treatment with the combination of ofloxacin (20 mg/kg) and fluconazole (20 mg/kg). The combination of ofloxacin and fluconazole may represent an effective strategy to treat infections caused by azole-resistant C. albicans.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s101560070014
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  • 2
    Digitale Medien
    Digitale Medien
    Ascending projections from the nucleus of the brachium of the inferior colliculus in the cat (1984)
    Springer
    Experimental brain research 54 (1984), S. 203-211 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Ascending auditory pathway ; Inferior colliculus ; Medial geniculate body ; Cat ; Autoradiography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ascending projections from the nucleus of the brachium of the inferior colliculus (NBIC) in the cat were studied by the autoradiographic tracing method. Many fibers from the NBIC ascend ipsilaterally in the lateral tegmentum along the medial border of the brachium of the inferior colliculus. At midbrain levels, fibers from the NBIC end in the superior colliculus, the pretectum, the central gray and the peripeduncular tegmental region bilaterally with ipsilateral predominance. NBIC fibers to the superior colliculus are distributed densely to laminae VI an III throughout the whole rostrocaudal extent of the colliculus. In the pretectum, NBIC fibers terminate in the anterior and medial nuclei and the nucleus of the posterior commissure. NBIC fibers to the dorsal thalamus are distributed largely ipsilaterally. Many NBIC fibers end in the dorsal and medial divisions of the medial geniculate body, but few in the ventral division. The NBIC also sends fibers to the suprageniculate, limitans and lateralis posterior nuclei and the lateral portion of the posterior nuclear complex; these regions of termination of NBIC fibers constitute, as a whole, a single NBIC recipient sector. Additionally, the NBIC sends fibers to the centralis lateralis, medialis dorsalis, paraventricular and subparafascicular nuclei of the thalamus.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00236219
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  • 3
    Digitale Medien
    Digitale Medien
    Intradural chordoma: case report and review of the literature (1994)
    Springer
    Neuroradiology 36 (1994), S. 313-315 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Chordoma ; MRI ; Ecchordosis physaliphora
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Chordomas are rare neoplasms arising from notochordal remnants found predominantly in the clivus and the sacrococcygeal regions. Most clivus chordomas show extradural extension and bone destruction. Such a tumour can rarely be intradural. This report is concerned with the radiological findings in prepontine intradural chordoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00593269
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  • 4
    Digitale Medien
    Digitale Medien
    Human amniotic epithelial cells are promising transgene carriers for allogeneic cell transplantation into liver (2000)
    Springer
    Journal of human genetics 45 (2000), S. 171-176 
    Details
    ISSN: 1435-232X
    Schlagwort(e): Key words Human amniotic epithelial cells ; Cell transplantation ; Albumin ; Gene therapy ; Liver stem cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract As human amniotic epithelial tissue is formed on about the eighth day after fertilization, human amniotic epithelial cells (hAEC) may have multipotency to differentiate into various organs, such as brain, heart, or liver. In this study, we showed evidence of the synthesis and excretion of albumin by hAEC, by immunostaining and enzyme-linked immunoassay. Reverse transcription-polymerase chain reaction (RT-PCR) and western blot analyses revealed the expression of albumin mRNA and protein, respectively. In addition, hAEC also demonstrated immunoreactivity to genetic markers of liver lineage, such as human serum albumin and α-fetoprotein. Transplanted hAEC to Scid mouse liver showed positive immunoreactivity to albumin and α-fetoprotein. Genetically modified cells containing the β-galactosidase (LacZ) gene (AxCALacZ) were integrated in liver parenchyma. Human polymorphic gene analysis in Scid mouse liver after the implantation of hAEC showed that these Scid mouse livers obviously contained this human-specific gene until day 7 after the cell transplantation. As hAEC do not cause any acute rejection by allotransplantation, we conclude that hAEC may be useful as a transgene carrier to treat patients with inherited liver diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s100380050205
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  • 5
    Digitale Medien
    Digitale Medien
    Removal of methyl orange by a system of insoluble chloromethylated poly(styrene-co-2-methyl-2-oxazoline) (1992)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 197 (1992), S. 41-47 
    Details
    ISSN: 0003-3146
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Beschreibung / Inhaltsverzeichnis: Die Entfernung von Methylorange (MO) aus wäßrigen Lösungen durch Adsorption an CMPS-MeOZO, einem Pfropfprodukt der Reaktion eines chlormethylierten Divinylbenzol-Styrol-Copolymeren (CMPS) mit 2-Methyl-2-oxazolin (MeOZO), wurde untersucht. Zur Charakterisierung des Adsorptionsverhaltens wurden die Freundlichund die Klotz-Gleichung geprüft, wobei erstere das Adsorptionsverhalten über einen breiteren MO-Anfangskonzentrationsbereich besser beschreibt. Die Adsorptionsmengen und -geschwindigkeiten sind mit CMPS-MeOZO(3)-Hy (Hydrolysat von CMPS-MeOZO(3)) größer als mit CMPS-MeOZO(4), was auf die weniger positive Teilladung des Stickstoffatoms in den Poly(N-acetyliminoethylen)- als in den Poly(iminoethylen)-Seitenketten zurückgeführt wird.
    Notizen: A study was made of the removal of methyl orange (MO) solutes in water by the reaction product (CMPS-MeOZO) of chloromethylated, divinylbenzene-crosslinked polystyrene (CMPS) with 2-methyl-2-oxazoline (MeOZO).The removal behavior was examined with regard to the conformity to the Freundlich adsorption formula and the Klotz equation, and noted to conform in wider range of initial concentration of MO to the former than to the latter. Removal rates and amounts removed were larger in CMPS-MeOZO(3)-Hy (hydrolyzate of CMPS-MeOZO(3)) than in CMPS-MeOZO(4). This is attributable to the less cationic charge of the nitrogen atoms in poly(N-acetyliminoethylene) than that of poly(iminoethylene) side chains.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/apmc.1992.051970103
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