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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of the binding of benzodiazepines to human serum albumin (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 280 (1973), S. 229-237 
    Details
    ISSN: 1432-1912
    Keywords: Benzodiazepines ; Albumin Binding ; Gel Filtration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The binding of eleven benzodiazepine derivatives to human serum albumin (HSA) was determined by means of sephadex gel filtration. The albumin binding of the substances was characterized by the percentage of bound drug, the binding constants k +, K 1 and m, the number of binding sites per albumin molecule, and the free binding energy. Under the conditions chosen in these experiments there seems to exist only one binding site of the same type for all investigated benzodiazepines at the HSA molecule. The affinities of the benzodiazepines to this binding site are very different. It is discussed which part of the benzodiazepine molecule represents the main binding group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501348
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of pH on the benzodiazepine-human serum albumin complex (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 283 (1974), S. 67-82 
    Details
    ISSN: 1432-1912
    Keywords: Benzodiazepines ; Albumin Binding ; Circular Dichroism ; Gel Filtration ; pH Dependence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of pH on the binding of benzodiazepine derivatives to HSA was studied by circular dichroism measurements and by gel filtration. The binding of nearly all benzodiazepines is increased by rising the pH from 6.60 to 8.20. For flurazepam, clonazepam, and nitrazepam this increase in binding is due to an increase of the affinities, while for the other substances the affinity remains constant and the number of binding sites is increased from one to two. The changes in binding of the benzodiazepines by rising the pH are explained by a cationic amino acid residue near or at the benzodiazepine binding site of the HSA molecule. This second binding site is not detectable by circular dichroism. For several of the substances rising the pH from 6.60 to 8.20, is accompanied by large alterations of the optical properties of the HSA-benzodiazepine complexes. These alterations are explained by changes of the asymmetric environment of the benzodiazepine binding site at the HSA molecule in the structural transition at slightly alkaline pH values. To explain the different reactions of the benzodiazepines within the N→B transition a theory is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500146
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of intravenous cyclophosphamide pulse on peripheral blood lymphocytes in lupus erythematosus patients (1997)
    Springer
    Rheumatology international 17 (1997), S. 55-60 
    Details
    ISSN: 1437-160X
    Keywords: Key words Lupus erythematosus ; Cyclophosphamide ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we investigated the long-term effect of intravenous pulse cyclophosphamide (CY) on lymphocyte surface antigens in systemic lupus erythematosus (SLE) patients. Blood samples derived from 17 lupus erythematosus patients were analysed using two- and three-colour flow cytometry. During the CY therapy, the total number of T lymphocytes (CD3+) was reduced by 31.4%, B lymphocytes (CD19+) by 67.4% and NK cells (CD16+) by 27.4%. Six months after the end of the CY regimen, these values recovered to entry levels. At the onset of the study we observed increased percentages of CD3+ CD25+, CD3+ CD4– CD8–, CD4+ CD29+, CD19+ and CD19+ CD5+ cells. The CY treatment regimen decreased the CD3+ CD25+, CD3+ CD4– CD8–, CD19+ and CD19+ CD5+ cells, but increased the CD3+ CD8+ subpopulation. Taken together, a deficiency of CD8+ T cells associated with CD4+ CD29+ predominance may imply an immune regulatory imbalance leading to abnormal CD4+ cell activation and in consequence to autoimmunity. Depletion of CD19+ cells combined with an enlargement of CD8 cells as a result of CY therapy may reduce the enhanced immune response in SLE patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006852
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cyclophosphamide therapy in life-threatening inoperable cystic hygromas (1995)
    Springer
    Pediatric surgery international 10 (1995), S. 199-201 
    Details
    ISSN: 1437-9813
    Keywords: Cystic hygroma ; Inoperable ; Cyclophosphamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Surgical excision is considered the treatment of choice for cystic hygromas (CH). However, radical surgery may result in serious complications, and nerve palsy due to dissection occurs in 12% – 33% of cases in most series. Resection is especially difficult and sometimes impossible if the lesion involves the floor of the mouth, tongue, and larynx. Different alternative treatment modalities have been advocated in cases of life-threatening, unresectable CHs, however, most of them are associated with severe side effects and doubtful effectiveness. Two children with inoperable CHs of the head and neck are presented. Since intralesional injection of sclerosing agents was unsuccessful, they were treated with IV cyclophosphamide. In both patients tumor size markedly regressed and vital functions stabilized, even though only partial remission was obtained. Cyclophosphamide seems to be a useful and well-tolerated treatment alternative in children with unresectable life-threatening CHs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171200
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    Paper (German National Licenses)
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