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  • 1
    ISSN: 1432-5233
    Keywords: Alcohol consumption ; Blood glucose ; Carboxyhemoglobin ; Dietary factors ; γ-gluta-myltransferase ; Oral glucose tolerance test ; Plasma insulin ; Relative body weight ; Smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Relative body weight (A/I weight), serum γ-glutamyl-transferase (GGT) and carboxyhemoglobin (COHb%) were related to glucose and insulin values at 0 and 120 min in a sizable, consecutive series of oral glucose tolerance tests (OGTTs) in middle-aged males. Partial and multiple correlation coefficients were calculated, and the squared stepwise multiple correlation coefficient was used to estimate how much of the variability of glucose and insulin could be accounted for by the three factors. No less than 14% of the glucose variability and 25% of the insulin variability at 2 h could be attributed to them, emphasizing the importance of keeping these three factors in mind when interpreting the results of OGTTs.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1617-4623
    Keywords: Gene regulation ; Transcriptional control ; DNA sequence ; Delta-lysin ; Staphylococcus aureus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A Tn551 insertional mutation in the accessory gene regulator (agr) locus of the Staphylococcus aureus chromosome resulted in the decreased production of at least seven extracellular toxins and enzymes and a simultaneous increase in the production of protein A and coagulase (Recsei et al. 1986). Adjacent to this locus we have now identified another gene, hld, transcribed into a 0.5 kb RNA which codes for the staphylococcal delta-lysin. The expression of hld, was totally repressed in a strain carrying the agr insertional mutation. Hybridization with strand-specific probes and primer extension analysis revealed that hld, and agr are transcribed in opposite directions, starting 188 nucleotides apart. The hld, gene is mainly expressed during the post-exponential growth phase and is totally repressed during early exponential growth. Determination of hld, mRNA half-life in different growth phases indicated that this regulation is at the level of transcription.
    Type of Medium: Electronic Resource
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