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  • 1
    Electronic Resource
    Electronic Resource
    Cardiovascular and alcohol-related deaths in abnormal glucose tolerant and diabetic subjects (1992)
    Springer
    Diabetologia 35 (1992), S. 39-44 
    Details
    ISSN: 1432-0428
    Keywords: Alcohol drinking ; cardiovascular diseases ; cirrhosis ; Type 2 (non-insulin-dependent) diabetes mellitus ; glucose tolerance test ; insulin resistance ; mortality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to compare the causes of death and parameters related to alcohol consumption, between subjects diagnosed as diabetic, clinically by their general practitioner, or glucose intolerant and in particular as diabetic, using the epidemiological criteria of an abnormal glucose level following an oral glucose tolerance test. The subjects in this study were 7035 working men, aged between 44 and 55 years, who attended the first follow-up examination of the Paris Prospective Study, between 1968 and 1973. They were classified as ‘clinically diagnosed diabetic’ or, following an oral glucose tolerance test and the World Health Organisation criteria, as having ‘oral glucose tolerance test diagnosed diabetes’, impaired glucose tolerance or normoglycaemia. The relative risk of death by cirrhosis, in comparison with the normoglycaemic group, was 21 (95 % confidence interval: 9.1–49) in the group diagnosed diabetic by the oral glucose tolerance test, significantly different (p 〈 0.02) from the group diagnosed diabetic clinically 3.1 (0.41–24); factors indicative of excessive alcohol consumption at baseline differed accordingly. In contrast, the relative risks for death by coronary heart disease were similar, 2.1 (1.0–4.1) and 2.7 (1.4–5.4) respectively; all of the factors defining the insulin resistance ‘Syndrome X’ (hyperglycaemia, hyperinsulinaemia, hypertension, hyperlipidaemia and also central obesity) and predictive of coronary heart disease were elevated in both groups of diabetic subjects. ‘Diabetes’, as diagnosed by the oral glucose tolerance test, might be the consequence of excessive alcohol consumption which could lead to insulin resistance, then to coronary heart disease, as well as to alcohol-related diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400850
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Body fat distribution and coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes mellitus: the Paris Prospective Study, 15-year follow-up (1992)
    Springer
    Diabetologia 35 (1992), S. 464-468 
    Details
    ISSN: 1432-0428
    Keywords: Epidemiology ; Paris Prospective Study ; coronary heart disease ; diabetes mellitus ; impaired glucose tolerance ; body fat distribution ; plasma triglyceride level ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Paris Prospective Study is a long-term, large-scale study of the factors predicting coronary heart disease in healthy middle-aged men. Subjects with impaired glucose tolerance or diabetes (not treated by insulin) at the first follow-up examination (n = 973) were selected from the total cohort for a separate analysis of the predictors of death from coronary heart disease. An index of body fat distribution, the iliac to thigh ratio, was entered into the list of potentially predictive variables, despite the fact that it had been measured one year before the first follow-up examination. After 15 years of mean follow-up, 41 of the selected subjects had died from coronary heart disease. Univariate analysis showed that these subjects differed from the subjects who died of another cause or who were alive at 15 years on the following variables: iliac to thigh ratio (p 〈 0.0005), plasma tri glyeride level (p 〈 0.006), systolic blood pressure (p 〈 0.01), and body mass index (p 〈 0.04). In multivariate regression analysis using the Cox model, only iliac to thigh ratio and triglyceride plasma level achieved statistical significance as independent predictors. This result supports the current hypothesis that upper-body fat distribution, a characteristic trait of subjects with diabetes of glucose intolerance, plays an important role towards their high cardiovascular risk. However, it is unlikely that this role would be mediated through the lipid abnormalities that have been described as associated with upper-body fat deposition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02342445
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes (1989)
    Springer
    Diabetologia 32 (1989), S. 300-304 
    Details
    ISSN: 1432-0428
    Keywords: Epidemiology ; risk factors ; coronary heart disease mortality ; diabetes ; impaired glucose tolerance ; plasma insulin level ; plasma triglyceride level
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Paris Prospective Study is a long-term investigation of the incidence of coronary heart disease in a large population of working men. The first follow-up examination involved 7,038 men, aged 43–54 years. Subjects with impaired glucose tolerance or diabetes (n=943) were selected from the total population for a separate analysis of coronary heart disease mortality risk factors. During a mean follow-up of 11 years, 26 of these 943 subjects with abnormal glucose tolerance died from coronary heart disease. Univariate analysis showed that plasma triglyceride level (p〈0.006), plasma cholesterol level (p〈0.02), and plasma insulin level both fasting and 2-h post-glucose load (p〈0.02), were significantly higher in subjects who died from coronary heart disease compared to those who did not. In multivariate regression analysis using the Cox model, plasma triglyceride level was the only factor positively and significantly associated with coronary death. The distribution of plasma triglyceride levels was clearly higher for the subjects who died from coronary heart disease compared to those who did not die from this cause or were alive at the end of the follow-up. This new epidemiological evidence that hypertriglyceridaemia is an important predictor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes suggests a possible role of dyslipidaemia in the excessive occurrence of atherosclerotic vascular disease in this category of subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265546
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    Paper (German National Licenses)
    Fulltext
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