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  • 1
    Electronic Resource
    Electronic Resource
    Zur Wirkung von Aldadiene-Kalium auf die Refraktärzeit des menschlichen Herzens (1972)
    Springer
    Journal of molecular medicine 50 (1972), S. 754-756 
    Details
    ISSN: 1432-1440
    Keywords: Effective Refractory period in the ventricle Canrenoate-K ; Effektive Refraktärzeit des Ventrikels ; Aldadiene-K
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Herzkatheteruntersuchungen am Menschen wurde die effektive Refraktärzeit (RZ) des rechten Ventrikels mit der Doppelstimulationsmethode gemessen. Bei Frequenzsteigerung, mittels elektrischer Stimulation erzeugt, kommt es physiologisch zu einer Verkürzung der RZ. Im Akutversuch wurde die Wirkung von Aldadiene-K als Kurzinfusion untersucht. 10 min und in einigen Fällen 45 oder 60 min nach 800 mg Aldadiene-K wurde die RZ erneut bestimmt, und zwar jeweils bei verschiedenen, bereits im Vorversuch am gleichen Patienten geprüften Frequenzen. Bei 5 in dieser Weise untersuchten Patienten wurde eine Verkürzung der RZ nach Aldadiene gefunden, verglichen mit den vorausgegangenen Kontrollmessungen bei den entsprechenden Herzfrequenzen. Diese beim Menschen gefundene Verkürzung der RZ nach Aldadiene-K spricht für eine positiv inotrope Wirkung der Substanz. Ein antiarrhythmischer Effekt wäre über eine Verbesserung der elektrischen Dispersion des Myokards denkbar.
    Notes: Summary The effective refractory period (RP) of the right ventricle was measured in patients during routine heart catheterisation by the method of paired stimulation. With increasing heart rate, induced by electrical stimulation, the RP shortens physiologically. The effect of Aldadiene-K (Canrenoate-K) was studied in acute infusion experiments. 10 min and in some cases 45 or 60 min after 800 mg Aldadiene-K, the RP was measured at different heart rates as it was done in the same patient before administration of the substance. In 5 patients studied in such way, there was a decrease of the RP after administration of aldadiene-K, compared to the control measurements at the corresponding heart rates. This decrease of the RP in man suggests a positive inotropic action of the substance. An antiarrythmic activity might be possible by means of an improvement of the electrical dispersion of the myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487626
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  • 2
    Electronic Resource
    Electronic Resource
    Clostridium difficile und Antibiotika-assoziierte Colitis bei Risikopatienten: Zweimonatige epidemiologische Studie auf einer Intensiveinheit (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1081-1087 
    Details
    ISSN: 1432-1440
    Keywords: Antibiotics ; C. difficile ; Enterocolitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A toxin produced by Clostridium difficile has been implicated in the pathogenesis of antibiotic-associated colitis. It is not known how often the microorganism is encountered in Germany particularly in high risk patients. Therefore, following a lethal case of colitis, stool samples of 90 patients and 30 staff members of an intensive care unit were screened routinely for C. difficile over 2 months. The organism was found in 6 of 41 patients treated with antibiotics (14.6%); four of them apparently acquired C. difficile while in hospital whereas in 2 a pre-existing carrier state could not be excluded. Colitis developed in 3 of the 6 patients as judged from endoscopy or a positive cytotoxin assay; in 2 patients (not subjected to endoscopy) colitis was suspected on clinical grounds, and 1 patient became an asymptomatic carrier. C. difficile was not found in 49 patients without antibiotic medication, in the health personal and in 12 patients of a general ward. Patients harbouring C. difficile were clustered in certain bed sites of the unit. Environmental studies recovered the microorganism from bed pan washing mashines of bedridden and from toilets of ambulant patients but not from other sites like the hands of the personal. These results suggest that chronic carriers of C. difficile, as far as they are identified by current bacteriological methods, are rare in Germany (not more than 2 out of 132 persons investigated, i.e. 1.5%). The frequent finding of C. difficile in patients treated in certain bed sites supports the view that the infection may be acquired from exogenous sources. Antibiotic-associated colitis should be considered more often when intensive care patients are treated with antibiotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496469
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    Paper (German National Licenses)
    Fulltext
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