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  • Aldose reductase inhibitor  (2)
  • Chemical Engineering  (2)
  • Mitochondria  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Characterization of aldose reductase and aldehyde reductase from rat testis
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 996 (1989), S. 30-36 
    Details
    ISSN: 0167-4838
    Keywords: (Rat testis) ; Aldehyde reductase ; Aldose reductase ; Aldose reductase inhibitor
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4838(89)90090-3
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Localization, isolation and properties of three NADPH-dependent aldehyde reducing enzymes from dog kidney
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 1078 (1991), S. 395-403 
    Details
    ISSN: 0167-4838
    Keywords: (Dog kidney) ; Aldehyde reductase ; Aldose reductase ; Aldose reductase inhibitor ; NADPH-dependent aldehyde reducing enzyme
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4838(91)90162-S
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Novel NADP-linked isocitrate dehydrogenase present in peroxisomes of n-alkane-utilizing yeast, Candida tropicalis: comparison with mitochondrial NAD-linked isocitrate dehydrogenase (1995)
    Springer
    Archives of microbiology 163 (1995), S. 104-111 
    Details
    ISSN: 1432-072X
    Keywords: Key words Peroxisomal NADP-linked isocitrate ; dehydrogenase ; NAD-linked isocitrate dehydrogenase ; Candida tropicalis ; Peroxisomes ; Mitochondria ; Cytosol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Peroxisomal NADP-linked isocitrate dehydrogenase (Ps-NADP-IDH) was purified for the first time from Candida tropicalis cells grown on n-alkane as a carbon source, which was effective in proliferation of peroxisomes. The properties of Ps-NADP-IDH were compared with those of mitochondrial NAD-linked isocitrate dehydrogenase (Mt-NAD-IDH) purified from the cells grown on acetate, in which peroxisomes did not proliferate. Ps-NADP-IDH was a homod imer of identical subunits (45 kDa), while Mt-NAD-IDH was suggested to be a heterooctamer composed of two types of subunits with different molecular masses (41 and 38 kDa). Kinetic studies revealed that Ps-NADP-IDH gave Michaelis-Menten saturation curves against isocitrate and NADP concentrations, whereas Mt-NAD-IDH was an allosteric enzyme regulated by ATP, AMP, and citrate. Inhibition by 2-oxoglutarate, a precursor of glutamate, was observed only for Ps-NADP-IDH. Both enzymes were inhibited by concomitant addition of oxalacetate and glyoxylate. The function of Ps-NADP-IDH seems to be completely discriminated from that of Mt-NAD-IDH as reflected by their distinct subcellular localizations. Furthermore, the properties of Ps-NADP-IDH were also compared with those of other mitochondrial and cytosolic IDHs from sources reported previously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381783
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  • 4
    Electronic Resource
    Electronic Resource
    Immunochemically distinct NADP-linked isocitrate dehydrogenase isozymes in mitochondria and peroxisomes of Candida tropicalis (1997)
    Springer
    Archives of microbiology 168 (1997), S. 389-395 
    Details
    ISSN: 1432-072X
    Keywords: Key wordsCandida tropicalis ; NADP-linked isocitrate dehydrogenase ; Mitochondria ; Peroxisomes ; Isozyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Although peroxisomal localization of NADP-linked isocitrate dehydrogenase (Idp) was first demonstrated in Candida tropicalis, the mitochondrial isozyme has not been found in this yeast. Here we report that the presence of mitochondrial Idp in the yeast was demonstrated by screening for its gene with a DNA probe containing conserved sequences of Idps from various organisms. The nucleotide sequence of the gene (CtIDP1) revealed a 1,290-bp open reading frame corresponding to a 430-amino-acid protein with a high similarity to previously reported Idps. Overexpression of CtIDP1 in Saccharomyces cerevisiae gave a high intracellular Idp activity, and the purified recombinant Idp was shown to be a homodimer with a subunit molecular mass of approximately 44 kDa, different from that of peroxisomal Idp (45 kDa) previously purified from C. tropicalis. Western blot analysis of the subcellular fractions from acetate-grown C. tropicalis with polyclonal antibodies raised against the recombinant CtIdp1 showed that the CtIdp1 in C. tropicalis was localized in mitochondria but not in peroxisomes. Similar levels of CtIDP1 mRNA and its protein product were detected in cells grown on glucose, acetate, and n-alkane, although a slight decrease was observed in n-alkane-grown cells. From these results, CtIdp1 was demonstrated to be mitochondrial Idp. The properties of mitochondrial Idp and peroxisomal Idp isozymes were proven to be similar, but they were immunochemically distinct, suggesting the presence of another gene responsible for peroxisomal Idp in C. tropicalis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050513
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrasonic velocity and attenuation of polymeric solids under oscillatory deformation: Apparatus and preliminary results (1989)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 29 (1989), S. 1124-1130 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A new apparatus has been constructed in which ultrasonic velocity and attenuation coefficients can be measured under oscillatory deformation. Using this apparatus, dynamic ultrasonic parameters were obtained with sufficient accuracy to investigate plastic deformation directly. It is found that this method has potential as a new tool for the study of solid polymers during deformation.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760291609
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of dynamic density by simultaneous measurement of ultrasonic velocity and elastic modulus under oscillatory deformation (1989)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 29 (1989), S. 1131-1135 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: It is proposed that dynamic density can be estimated from simultaneous measurements of ultrasonic velocity and modulus under an oscillatory deformation. An experimental investigation was carried out and a theoretical model applied. Preliminary experiments show that measurement of the dynamic density is a major aid to the study of plastic deformation.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760291610
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    Paper (German National Licenses)
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