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  • 1
    Electronic Resource
    Electronic Resource
    Synthetic phospholipids as substrates for phospholipase C from Bacillus cereus
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1125 (1992), S. 166-170 
    Details
    ISSN: 0005-2760
    Keywords: Alkylphosphocholine ; Diacylglycerol ; Lysophospholipid ; Phospholipase C ; Synthetic phospholipid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(92)90041-S
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical and pharmacologic phase I study of Cemadotin—HCl (LU103793), a novel antimitotic peptide, given as 24-hour infusion in patients with advanced cancer (1998)
    Springer
    Annals of oncology 9 (1998), S. 1323-1330 
    Details
    ISSN: 1569-8041
    Keywords: Cematodin–HCL ; Dolastin 15 analog ; phase I study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To determine the maximum tolerable dose (MTD), principal toxicity, and pharmacologic behaviour of Cemadotin—HCl, a novel antimitotic peptide. Patients and methods: Cemadotin—HCl (10.0 to 27.5 mg/m2/day every three weeks) was administered as a 24-hour intravenous (i.v.) continuous infusion to patients with advanced cancer. Pharmacokinetic analyses were performed during the first treatment cycle. Blood samples were taken over 48 hours and analyzed by radioimmunoassay. Results: Hypertension was the dose-limiting toxicity (DLT). This type of toxicity was observed at all dose levels, but grade 3 (CTC) was observed only at dose levels 20.0, 25.0 and 27.5 mg/m2. This effect was reversible but in three patients associated with signs of cardiac ischemia. Other significant toxic effects were neutropenia, asthenia, tumor pain and transient liver enzyme elevation. A linear pharmacokinetics was observed. The best curve fit was obtained with a two-compartment model with a terminal half-life of ≈10 hours at each dose level, a volume of distribution at steady state of ≈9 l/m2 and a total clearance of ≈0.6 l/hour/m2. Neither partial nor complete responses were observed although minor tumor regressions were seen in a patient with carcinoma of unknown primary (CUP) and in another patient with liver metastases from a colon cancer. Conclusions: Hypertension was the dose-limiting toxicity of Cemadotin—HCl administered as a continuous 24-hour infusion. The recommended dose for further evaluation of its anticancer efficacy in disease-oriented phase II studies with this schedule is 15.0 mg/m2. The nature of the principal cardio-vascular toxicity remains unclear. The observed toxicities appeared to be significant but manageable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008430515881
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetic behavior and antineoplastic activity of liposomal hexadecylphosphocholine (1994)
    Springer
    Cancer chemotherapy and pharmacology 34 (1994), S. 393-398 
    Details
    ISSN: 1432-0843
    Keywords: Liposomes ; Alkylphosphocholine ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hexadecylphosphocholine (HePC) shows remarkable antineoplastic efficacy in Sprague-Dawley rats bearing methylnitrosourea-induced mammary carcinoma. Unfortunately, this is accompanied by detrimental side effects that include gastrointestinal damage, body weight loss, and thrombophlebitis after i.v. injection, which has precluded the use of the HePC in humans, where nausea and vomiting can occur at noneffective dose levels. We have developed small unilamellar vesicles (SUVs) composed of HePC, cholesterol, and 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol, which can be given p. o. and i.v. In contrast to the free drug, the toxicity of liposomal HePC is shown to be greatly reduced, and there is no risk of thrombophlebitis. Single administration of equimolar HePC doses results in differing pharmacokinetic values for free HePC (p. o.) and HePC-SUVs (p. o., i.v.).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685563
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  • 4
    Electronic Resource
    Electronic Resource
    Ueber den Ultramarin (1872)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 5 (1872), S. 893-896 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.18720050289
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    Paper (German National Licenses)
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