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  • Analytical Chemistry and Spectroscopy  (19)
  • Allium cepa L  (2)
  • CCAATT enhancer binding protein  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Transcription, adipocyte differentiation, and obesity (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 347-352 
    Details
    ISSN: 1432-1440
    Keywords: Adipocytes ; CCAATT enhancer binding protein ; Gene expression ; Nuclear receptors ; Peroxisome proliferator activated receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Differentiation of adipogenic precursor cells into mature adipocytes is a complex phenomenon, characterized by an ordered expression of adipocyte-specific genes, triggered by a set of interacting transcription factors. The most important transcription factors involved in this process are the γ form of peroxisome proliferator activated receptors (PPARγ) and the various members of the CCAAT enhancer binding proteins (α, β, and δ). In addition to PPARγ and these enhancer binding proteins, several other transcription factors, including ADD-1 (SRE-BP), HMGI-C, are involved in regulating this process. Altered activity and/or expression of these transcription factors, will induce the expression of target genes in the differentiating cells, ultimately resulting in the phenotypical characteristics of the adipocytes. It is speculated that modulation of these transcription factors by either pharmacological or dietary manipulations might influence adipocyte differentiation and prove beneficial in the prevention and treatment of obesity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210629
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  • 2
    Electronic Resource
    Electronic Resource
    Transcription, adipocyte differentiation, and obesity (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 347-352 
    Details
    ISSN: 1432-1440
    Keywords: Key words Adipocytes ; CCAATT enhancer binding protein ; Gene expression ; Nuclear receptors ; Peroxisome proliferator activated receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Differentiation of adipogenic precursor cells into mature adipocytes is a complex phenomenon, characterized by an ordered expression of adipocyte-specific genes, triggered by a set of interacting transcription factors. The most important transcription factors involved in this process are the γ form of peroxisome proliferator activated receptors (PPARγ) and the various members of the CCAAT enhancer binding proteins (α, β, and δ). In addition to PPARγ and these enhancer binding proteins, several other transcription factors, including ADD-1 (SRE-BP), HMGI-C, are involved in regulating this process. Altered activity and/or expression of these transcription factors, will induce the expression of target genes in the differentiating cells, ultimately resulting in the phenotypical characteristics of the adipocytes. It is speculated that modulation of these transcription factors by either pharmacological or dietary manipulations might influence adipocyte differentiation and prove beneficial in the prevention and treatment of obesity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050036
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immediate disruption of spindle poles and induction of additional microtubule-organizing centres by a phenylcarbamate, during plant mitosis (1998)
    Springer
    Protoplasma 204 (1998), S. 119-127 
    Details
    ISSN: 1615-6102
    Keywords: Phenylcarbamates ; Multipolar spindles ; Microtubule-organizing centres ; Aneuploidy ; Allium cepa L
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The herbicide carbetamide [(R)-1-(ethylcarbamoyl) ethylphenylcarbamate], in the 0.4 to 0.8 mM range, efficiently induced multipolar mitoses inAllium cepa L. The frequency of multipolar anaphases rose earlier and reached higher values when both concentration and time of treatment increased, up to a maximum of 90% after 1 h of treatment. To identify the physiological target, the kinetics of induction of multipolar mitoses were followed during recovery from very short treatments (5, 10, and 15 min). Tubulin immunodetection showed that phenylcarbamate immediately disrupts the cohesion between the different bundles of microtubule minus ends which converge at the pole. The spindle was rendered multipolar about three times more efficiently in metaphase than in anaphase. The observations do not support any effect of the herbicide on the tubulin polymerization-depolymerization cycle, and suggest that the minus ends of the microtubules remained stabilized in carbetamide. Thus, the density of kinetochore microtubules and their lengths were unmodified in the individual chromosomes which became detached from both spindle poles in response to the herbicide. Extra microtubule-organizing centres for the assembly of both preprophase band and phragmoplast (the tubulin arrays which characterize the microtubular cycle responsible for cytokinesis in plant cells) were also rapidly induced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01280318
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  • 4
    Electronic Resource
    Electronic Resource
    Microtubular structures developed in response to a carbamate herbicide in plant mitosis (1997)
    Springer
    Protoplasma 200 (1997), S. 65-70 
    Details
    ISSN: 1615-6102
    Keywords: Carbamates ; Microtubules ; Mitosis ; Cytokinesis ; Caffeine ; Allium cepa L
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Indirect immunodetection of tubulin showed that the herbicide carbetamide activated silent signals left by the preprophase band (PPB) and by old phragmoplasts. Thus, after half an hour of treatment, 5.3% of anaphases inAllium cepa L. meristems showed spindle microtubules pointing to sites of the longitudinal cell membranes which, under control conditions, would only start attracting microtubules from the growing phragmoplast at late telophase. After 2 h, 12.8% of the telophases showed not only the expected phragmoplast between the two sister nuclei, but one or two additional phragmoplasts, at one or both cell tips, the sites of the phragmoplasts from the telophases of previous cycles. A few binucleate cells, obtained by aborting phragmoplast formation by a short caffeine treatment, developed three phragmoplasts in their next mitosis (bimitosis) in the presence of carbetamide: one between each sister pair of telophasic nuclei plus an extra one. The latter also occupied the site of the phragmoplast of the telophase of the previous cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01280735
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  • 5
    Electronic Resource
    Electronic Resource
    Isotope ratio mass spectrometry: Analysis of wines from different european countriesPresented at the 11th Annual Meeting of the French Mass Spectrometry Society, held at Rouen, 20-22 September 1994. (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 967-970 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Natural stable isotope ratios for carbon, hydrogen and oxygen depend on the origin of the studied chemical compound. Such a precept is the basis of the control of the authenticity of food and especially alcoholic beverages. 13C/12C analysis of ethanol as well as 18O/16O determination of water contained in wines from different European countries underline the importance of the photosynthetic pathway as well as of the environmental and climatological conditions of the vine. Interesting results in agreement with isotopic fractionation rules for the geographical origin of the samples were obtained. That encouraged us to propose the establishment of a database for isotopic parameters in wines.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290081212
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  • 6
    Electronic Resource
    Electronic Resource
    Chiral Resolution of RR, SS-Hydrobenzoin by Liquid Chromatography Using Borate-Cyclodextrin Complexation (1998)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 21 (1998), S. 414-416 
    Details
    ISSN: 0935-6304
    Keywords: chiral separation ; HPLC ; diols ; borate complexation ; cyclodextrin ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 7
    Electronic Resource
    Electronic Resource
    Metabolism of 1,1,1,2,2-pentafluorohexane and 1,1-difluorocyclohexane by rat liver microsomes in vitro (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 512-521 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Metabolism of 1,1,1,2,2-pentafluorohexane with liver microsomes from phenobarbital-treated rats gave only one metabolite, namely, the 5-hydroxy derivative. Under similar conditions 1,1-difluorocyclohexane was metabolized to give mainly the 3- and 4-hydroxy derivatives in the ratio 1:∼5.5 The structures of these metabolites were established by chemical ionization (CI) and/or electron impact (EI) mass spectrometry and confirmed by synthesis in the case of 1,1-difluorocyclohexan-4-ol. Oxidation of 1,1-difluorocyclohexane with lead tetrakis(trifluoroacetate) also gave, inter alia, the 3- and 4-hydroxy derivatives. In saturated hydrocarbons complete replacement of hydrogen by fluorine at one particular carbon will not only block microsomal hydroxylation thereat but will also inhibit hydroxylation at neighbouring hydrogen-bearing carbons, (α almost completely, β markedly, γ slightly).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200111005
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  • 8
    Electronic Resource
    Electronic Resource
    Etude par RMN du carbone des systèmes C=N: imines, phénylhydrazones, semicarbazones, amidines, iminoéthers (1975)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 7 (1975), S. 326-330 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: A carbon-13 NMR study of compounds containing C=N or conjugated C—N bonds (iminoethers, saturated and unsaturated aliphatic imines, amidines, oximes, phenylhydrazones, semicarbazones) is presented. The influence of the Z/E isomerism, the substituents and the steric effects on the chemical shifts are discussed.
    Notes: Ce travail présente une étude par RMN de carbone-13 de composés comportant une double liaison C=N simple et conjuguée (iminoéthers, imines aliphatiques, imines éthyléniques, amidines, oximes, phénylhydrazones, semicarbazones). L'influence de la stéréoisomérie Z/E, des substituants et le rǒle de l'effet stérique sur le déplacement chimique sont discutés.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270070707
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  • 9
    Electronic Resource
    Electronic Resource
    Application of 13C and 15N spectroscopy to the study of electronic delocalization in N—N bonds: Nitrosamines, hydrazones, triazenes and related protonated species (1979)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 12 (1979), S. 263-270 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 13C and 15N spectroscopies at natural abundance have been applied to the study of nitrogen lone-pair delocalization in N—N containing compounds: nitrosamines, nitramines, hydrazines, hydrazones and triazenes. Structure-chemical shift correlations have been derived for nitrosamines; the 13C upfield effect of a γ substituent has been used for assigning the configuration of both diastereoisomers in N,N-unsymmetrically substituted nitrosamines. Equations have been computed which permit the prediction of the electronic delocalization, expressed in terms of free enthalpy of activation ΔG≠298, as a function of δ15N and of the length of the N—N bond. 15N spectroscopy has also been applied to the study of the protonated species of nitrosamines and of acceptor-donor complexes of nitrosamines with Lewis acids. The behaviour of such N—N containing compounds is compared to that of amides.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270120502
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  • 10
    Electronic Resource
    Electronic Resource
    Application of 15N spectroscopy and dynamic NMR to the study of ureas, thioureas and their lewis acid adducts (1980)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 13 (1980), S. 396-402 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Rotational barriers and 15N chemical shifts have been measured in a number of ureas and thioureas. As anticipated on the basis of the 15N shifts, several previously unobserved rotational barriers could be detected by using lanthanide reagents or a high field spectrometer. Nearly constant effects on both the rotational activation energy and the 15N shift are produced on going from ureas to the corresponding thioureas, and correlations are found between the ΔG
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270130603
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