ISSN:
1432-2072
Keywords:
l-Dihydroxyphenylalanine
;
dl-Dihydroxyphenylalanine
;
d-Amphetamine
;
Alpha Methyl-p-Tyrosine
;
Haloperidol
;
Methadone
;
Morphine
;
Aggression
;
Rearing
;
Vocalization
;
Biting
;
Dopaminergic Neuropathway
;
Supersensitivity
;
Narcotic Addiction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Aggregation during morphine abstinence elicited social aggression (rearing, vocalization, attack-bites) in the morphine dependent rats. Pretreatment with l-dihydroxyphenylalanine (50 mg/kg), dl-dihydroxyphenylalanine (200 mg/ kg), dextro-amphetamine sulfate (2 mg/kg) or apomorphine hydrochloride (1.25 mg/kg) enhanced that aggression severalfold. Alpha methyl-p-tyrosine (200 mg/kg) abolished the morphine withdrawal aggression that was elicited either by mere aggregation or by aggregation combined with amphetamine. However, alpha methyl-p-tyrosine did not block the aggression in apomorphine treated rats. Haloperidol (0.63–2.5 mg/kg) also blocked the aggression due to mere abstinence or abstinence supersensitized by amphetamine. Similarly, methadone hydrochloride (5–20 mg/kg) blocked morphine withdrawal aggression supersensitized by apomorphine. These data are interpreted to suggest dopaminergic basis of morphine withdrawal aggression and a latent supersensitivity of dopaminergic neuropathways during morphine dependence.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428682
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