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  • 1
    Electronic Resource
    Electronic Resource
    Alpha-feto-protein (AFP) and human chorionic gonadotropin (HCG) as biochemical markers of intracranial germ-cell tumours (1979)
    Springer
    Acta neurochirurgica 50 (1979), S. 67-69 
    Details
    ISSN: 0942-0940
    Keywords: Pineal neoplasm ; Alpha-feto-protein ; Human chorionic gonadotropin ; Embryonal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 17-year-old male with an intracranial endodermal sinus tumour and chorio-carcinoma, had elevated AFP and HCG levels. During therapy, these levels returned to normal. The importance of both AFP and HCG for the diagnosis and treatment of certain cranial tumours in childhood is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01813551
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Influence of Naloxone on the cellular immune response to head-up tilt in humans (1997)
    Springer
    European journal of applied physiology 76 (1997), S. 415-420 
    Details
    ISSN: 1439-6327
    Keywords: Key words Natural killer cells ; β-endorphin ; Catecholamines ; T cells ; Aviation medicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate a possible role for β-endorphin in the stress-induced modulation of natural killer (NK) cells, immunologically competent blood cells were followed in eight male volunteers administered either Naloxone or saline (control) during head-up tilt maintained until the appearance of presyncopal symptoms (PS). The PS appeared more rapidly with Naloxone compared to control [5.7 (SEM 1.1) vs 22.3 (SEM 5.1) min; P = 0.01]. The NK cell activity increased threefold during PS partly due to an increase in CD16+ and CD56+ NK cells in blood. In support, NK cell activity boosted with interferon-α and interleukin 2 rose in parallel with unboosted NK cell activity and NK cell concentration and activities returned to the baseline level after 105 min. The total lymphocyte count and the concentrations of CD3+, CD4+, CD8+, CD16+, and CD56+ cells increased during PS. Head-up tilt also induced an increase in plasma adrenaline concentration during control PS and a rise in plasma cortisol and adrenocorticotropic hormone concentrations up to 30 min thereafter, whereas no significant changes were found in plasma concentrations of noradrenaline, growth hormone, or β-endorphin. The results would indicate an influence of endorphin on the increase in plasma adrenaline concentration during head-up tilt and at the same time contra-indicate a significant role for adrenaline in the provocation of PS. The influence of head-up tilt on plasma β-endorphin was too small to influence the modulation of the cellular immune system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004210050270
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The immune system and serum glutamine during a triathlon (1996)
    Springer
    European journal of applied physiology 74 (1996), S. 428-434 
    Details
    ISSN: 1439-6327
    Keywords: Lymphocyte proliferation ; Lymphocyte subpopulations ; Lymphokine activated killer cells ; Natural killer cells ; Glutamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined the influence of a triathlon on the immune system and on serum amino acid concentrations. Eight male triathletes swam 2500 m, bicycled 81 km, and ran 19 km. The concentration of total serum amino acids decreased during the race, with the lowest values occurring 2 h postexercise. Similarly, serum glutamine concentration declined from 468 (SEM 24) (prerace) to 318 (SEM 20) μmoll−1 (2 h postrace) and the natural killer (NK) and lymphokine activated killer (LAK) cell activities were suppressed 2 h postexercise (P 〈 0.05). Blood mononuclear cell proliferation decreased during exercise with the lowest value observed after running. The leucocyte concentration increased during and after exercise due to an increase in the concentration of neutrophils and monocytes. There was no significant change in lymphocyte concentration during or after the exercise. The plasma concentration of interleukin-6 did not change and the plasma concentration of interleukin-1β and tumor necrosis factor-α were below detection limits. The LAK cell cytotoxicity, but not NK cell activity or proliferative response, was significantly correlated with serum glutamine concentrations (r = 0.39,P 〈 0.01). This study confirms that prolonged endurance exercise results in changes in the cytotoxic function of the NK and LAK cells as well as the proliferative response. The time-course of changes in serum glutamine concentrations were best parallelled by changes in LAK cell activities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02337723
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effects of elevated plasma noradrenaline concentration on the immune system in humans (1998)
    Springer
    European journal of applied physiology 79 (1998), S. 93-98 
    Details
    ISSN: 1439-6327
    Keywords: Keywords Exercise ; Noradrenaline ; Natural killer cells ; Lymphocytes ; Neutrophils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was designed to test the hypothesis that elevated plasma noradrenaline concentrations contribute to the exercise-induced modulation of the activity and percentage of the natural killer (NK) cells, and the leucocyte concentration. In a single blind, controlled, cross-over study, eight healthy men had noradrenaline infused for 1 h and achieved plasma noradrenaline concentrations comparable (20-fold increment) to those previously observed in cycle ergometer exercise (75% of maximal oxygen uptake for 1 h). The noradrenaline infusion increased the unstimulated, the interleukin-2 and interferon-α stimulated NK cell activity, and the percentage of CD16+ cells. The natural lytic activity per CD16+ cell however, did not change. The concentration of neutrophils, lymphocytes and CD16+ cells increased during the infusion. The neutrophil concentration remained elevated 2 h after infusion, at which time the lymphocyte count was back to normal. These results are comparable with the effects in the exercise model, and it is suggested that the augmented plasma noradrenaline concentrations, seen during extreme exercise, may participate in the exercise-induced immune changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004210050479
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The immune system and serum glutamine during a triathlon (1996)
    Springer
    European journal of applied physiology 74 (1996), S. 428-434 
    Details
    ISSN: 1439-6327
    Keywords: Key words Lymphocyte proliferation ; Lymphocyte subpopulations ; Lymphokine activated killer cells ; Natural killer cells ; Glutamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This study examined the influence of a triathlon on the immune system and on serum amino acid concentrations. Eight male triathletes swam 2500 m, bicycled 81 km, and ran 19 km. The concentration of total serum amino acids decreased during the race, with the lowest values occurring 2 h postexercise. Similarly, serum glutamine concentration declined from 468 (SEM 24) (prerace) to 318 (SEM 20) μmol l-1 (2 h postrace) and the natural killer (NK) and lymphokine activated killer (LAK) cell activities were suppressed 2 h postexercise (P〈0.05). Blood mononuclear cell proliferation decreased during exercise with the lowest value observed after running. The leucocyte concentration increased during and after exercise due to an increase in the concentration of neutrophils and monocytes. There was no significant change in lymphocyte concentration during or after the exercise. The plasma concentration of interleukin-6 did not change and the plasma concentration of interleukin-1β and tumor necrosis factor-α were below detection limits. The LAK cell cytotoxicity, but not NK cell activity or proliferative response, was significantly correlated with serum glutamine concentrations (r=0.39,  P〈0.01). This study confirms that prolonged endurance exercise results in changes in the cytotoxic function of the NK and LAK cells as well as the proliferative response. The time-course of changes in serum glutamine concentrations were best parallelled by changes in LAK cell activities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004210050096
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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