ISSN:
1432-0533
Keywords:
Alzheimer's disease
;
Cerebral cortex
;
β-amyloid protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The spatial pattern of β-amyloid protein (BAP) deposits in Alzheimer's disease cerebral cortex was investigated. In cortical areas where the accumulation of BAP was relatively sparse, the deposits tended to accumulate vertically in a columnar arrangement. Typically, these aggregates consisted of both consolidated and diffuse deposits approximately 200 to 600 μm in width. Blood vessels running perpendicularly to the pial surface were sometimes observed penetrating the center of these colunms, but this was not a consistent finding. These BAP extracellular aggregates might be related to the columnar organization of the cerebral cortex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00334451
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