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  • Alzheimer type I glia  (1)
  • Histopathology  (1)
  • Insulin receptor  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Further observations on Tau-positive glia in the brains with progressive supranuclear palsy (1993)
    Springer
    Acta neuropathologica 85 (1993), S. 308-315 
    Details
    ISSN: 1432-0533
    Keywords: Progressive supranuclear palsy ; Astrocyte ; Alzheimer type I glia ; CD44 ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The previously reported unusual, Tau-positive glia with astrocytic morphology seen in brain tissues from cases of progressive supranuclear palsy (PSP) were re-examined immunohistochemically using antibodies to CD44 and vimentin, as well as Alz-50. Four brains of PSP cases, one of whom had atypical clinical features, were examined. All four cases showed the unusual glia which were positive to Alz-50 and anti-CD44 antibodies, but negative to anti-vimentin antibody. Ultrastructurally, they had either paired nucleated or lobulated nuclei and the cytoplasm frequently contained lipofuscin pigment. The CD44 was located on the surface of the cell bodies and their processes. Such glia were most numerous in the striatum in all cases. They also appeared in the cortex and some subcortical nuclei in the three typical cases. They were not seen in the lower brain stem or cerebellum. In their morphological characteristics and regionally specific appearance, these unusual glia seemed similar to the Alzheimer type I glia which are commonly seen in hepatic encephalopathy or Wilson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227727
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 343-348 
    Details
    ISSN: 1432-0533
    Keywords: Parkinson's disease ; Substantia nigra ; Insulin receptor ; Immunochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunohistochemistry using both a newly developed polyclonal, and a commercially available monoclonal, anti-insulin receptor antibody was done on the midbrain from cases of idiopathic Parkinson's disease (PD), Alzheimer's disease, amyotrophic lateral sclerosis, vascular parkinsonism and non-neurological controls. Both antibodies gave indentical patterns of neuronal staining. The neurons of the oculomotor nucleus were immunopositive in all the brains. However, the neurons in the pars compacta of the substantia nigra, paranigral nucleus, parabrachial pigmental nucleus, tegmental pedunculopontine nucleus, supratrocheal nucleus, cuneiform nucleus, subcuneiform nucleus and lemniscus medialis, which were positive in other diseases and in non-neurological controls, were not stained by these antibodies in PD brains. These results suggest that, in PD, a dysfunction of the insulin/insulin receptor system may precede death of the dopaminergic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313602
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Senile plaques, amyloid β-protein, and acetylcholinesterase fibres: laminar distributions in Alzheimer's disease striate cortex (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 292-299 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Visual cortex ; Amyloid ; Acetylcholinesterase ; Histopathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The laminar distributions of senile plaques and amyloid β-protein (AβP) within the striate cortex of patients with Alzheimer's disease (AD) were studied with enhanced Bielschowsky (roughly equivalent to the Campbell technique) and immunohistochemical methods. The laminar distribution of acetylcholinesterase (AChE) fibres within the striate cortex of both AD patients and control patients was studied with an enzyme histochemical method. Quantification of Bielschowsky-stained plaque numbers along intersect lines drawn parallel to laminar boundaries revealed a significant aggregation of plaques at the interface of layers IVc and V. Lines drawn through layer VI intersected significantly fewer plaques than lines through other laminae. Immunoperoxidase staining for AβP revealed a similar distribution fo senile plaques, and additional, prominent, diffuse deposits of AβP within layers I and IVc. AChE fibres were markedly depleted in the striate cortex of AD cases. In control cases, AChE fibres were, like AβP immunoreactivity, concentrated within layers I and IVc. The results indicate that enhanced silver methods may not reveal the complete distribution of AβP. The codistribution of AβP-immunoreactive diffuse amyloid deposits and AChE fibres to the same cortical laminae is consistent with the possibility that these deposits may be formed from degenerating cholinergic elements. The formation of a line of senile plaques at the interface of two cortical laminae within the striate cortex, in an anatomically analogous situation to a similar line of plaques within the dentate gyrus, suggests that formation of well-defined plaques may be accelerated by the interaction of specific neuronal systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296792
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    Paper (German National Licenses)
    Fulltext
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