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  • 1
    Electronic Resource
    Electronic Resource
    Failure to detect any effect of amalgam restorations on peripheral blood lymphocyte populations (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 728-734 
    Details
    ISSN: 1432-1440
    Keywords: Amalgam ; Lymphocytes ; Immune system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dental amalgam has been considered to have adverse side effects on the immune system. Reports have been contradictory, indicating both an increase and a decrease in peripheral blood lymphocyte counts associated with amalgam restorations. We investigated two groups of patients, one of which was treated with amalgam restorations for the first time. In the other group, all existing amalgam fillings were removed. Prior to and after treatment, we determined the absolute and relative numbers of granulocytes, lymphocytes, monocytes, T cells, B cells, cytotoxic T cells, helper T cells and natural killer cells. In addition, functional investigations of T cells were performed. We failed to find any effect of amalgam restorations on the immune system in terms of the parameters investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180738
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis (1995)
    Springer
    Annals of hematology 70 (1995), S. 309-312 
    Details
    ISSN: 1432-0584
    Keywords: Key words Interleukin-6 ; Aplasia ; Bone marrow transplantation ; Hematopiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Interleukin-6 (IL-6) has been shown to be an inducer of the acute-phase response (APR) and to be involved in the pathogenesis of several disease states, including graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT). As blood cells of the monocyte lineage are known to be major producers of this cytokine, we wondered whether extreme peripheral leukopenia following total ablation of hematopoiesis could compromise IL-6 production during the first days after allogeneic or autologous BMT. In the absence of detectable circulating leukocytes we measured elevated IL-6 levels in six children having fever (≥38°  C) of presumed infectious origin with an average of 74±60 units/ml (range 19–309 units/ml). IL-6 levels in febrile children having a normal hematopoiesis (118±254 units/ml, range 17–1213 units/ml) were not significantly higher than those found in the febrile BMT group (p〉0.05). Moreover, there was a clear association between elevated IL-6 levels and the presence of fever. C-reactive protein (CRP) was also elevated (≥1 mg/dl), whereas tumor-necrosis factor alpha (TNF) was undetectable (〈1 pg/ml). Two transplanted patients without fever during the period of total aplasia had neither detectable CRP nor IL-6, thus demonstrating that the transplant procedure itself does not induce an APR. Our data obtained during maximal leukopenia following BMT show that a functional hematopoietic system is not necessary for regular production of IL-6, which is associated with fever. Cells of nonhematopoietic origin may contribute to this production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696617
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis (1995)
    Springer
    Annals of hematology 70 (1995), S. 309-312 
    Details
    ISSN: 1432-0584
    Keywords: Interleukin-6 ; Aplasia ; Bone marrow transplantation ; Hematopiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Interleukin-6 (IL-6) has been shown to be an inducer of the acute-phase response (APR) and to be involved in the pathogenesis of several disease states, including graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT). As blood cells of the monocyte lineage are known to be major producers of this cytokine, we wondered whether extreme peripheral leukopenia following total ablation of hematopoiesis could compromise IL-6 production during the first days after allogeneic or autologous BMT. In the absence of detectable circulating leukocytes we measured elevated IL-6 levels in six children having fever (≥38° C) of presumed infectious origin with an average of 74±60 units/ml (range 19–309 units/ml). IL-6 levels in febrile children having a normal hematopoiesis (118±254 units/ml, range 17–1213 units/ml) were not significantly higher than those found in the febrile BMT group (p〉0.05). Moreover, there was a clear association between elevated IL-6 levels and the presence of fever. C-reactive protein (CRP) was also elevated (≥1 mg/dl), whereas tumor-necrosis factor alpha (TNF) was undetectable (〈1 pg/ml). Two transplanted patients without fever during the period of total aplasia had neither detectable CRP nor IL-6, thus demonstrating that the transplant procedure itself does not induce an APR. Our data obtained during maximal leukopenia following BMT show that a functional hematopoietic system is not necessary for regular production of IL-6, which is associated with fever. Cells of nonhematopoietic origin may contribute to this production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696617
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Morphology and distribution of Müller cells in the retina of the toad Bufo marinus (1993)
    Springer
    Cell & tissue research 272 (1993), S. 183-192 
    Details
    ISSN: 1432-0878
    Keywords: Retina ; Müller cells ; Neuron-specific enolase ; Immunocytochemistry ; Quantitative analysis ; Ultrastructure ; Bufo marinus (Anura)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have previously shown that an antibody against neuron-specific enolase (NSE) selectively labels Müller cells (MCs) in the anuran retina (Wilhelm et al. 1992). In the present study the light- and electron-microscopic morphology of MCs and their distribution were described in the retina of the toad, Bufo marinus, using the above antibody. The somata of MCs were located in the proximal part of the inner nuclear layer and were interconnected with each other by their processes. The MCs were uniformly distributed across the retina with an average density of 1500 cells/mm2. Processes of MCs encircled the somata of photoreceptor cells isolating them from each other by glial sheath, except for those of the double cones. Some of the photoreceptor pedicles remained free of glial sheath. Electron-microscopic observations confirmed that MC processes provide an extensive scaffolding across the neural retina. At the outer border of the ganglion cell layer these processes formed a non-continuous sheath. The MC processes traversed through the ganglion cell layer and spread beneath it between the neuronal somata and the underlying optic axons. These processes formed a continuous inner limiting membrane separating the optic fibre layer from the vitreous tissue. Neither astrocytic nor oligodendrocytic elements were found in the optic fibre layer. The significance of the uniform MC distribution and the functional implications of the observed pattern of MC scaffolding are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00323585
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    Paper (German National Licenses)
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