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  • 1
    Electronic Resource
    Electronic Resource
    Pure lesionectomy versus tailored epilepsy surgery in treatment of cavernous malformations presenting with epilepsy (2000)
    Springer
    Neurosurgical review 23 (2000), S. 80-83 
    Details
    ISSN: 1437-2320
    Keywords: Key words Cavernous malformations ; Epilepsy ; Lesionectomy ; Epilepsy surgery ; Dual pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cerebral cavernous malformations (CM) are well-circumscribed vascular malformations that often present with epileptic seizures. Although patients may initially benefit from antiepileptic drugs, surgical treatment may become necessary due to medically intractable seizures. However, it is unclear whether lesionectomy alone or tailored epilepsy surgery with previous invasive monitoring is the optimal strategy in such cases. We report two patients with epileptic seizures due to CM. One patient with few seizures prior to surgery became seizure-free following resection of the CM and the surrounding tissue. In the second patient with long-lasting epilepsy, lesionectomy was performed because of the proximity to a functioning left hippocampus. This limited resection failed and the patient still had seizures. Subsequently, invasive monitoring with intracranial depth and strip electrodes was performed in order to localize the epileptogenic area and determine whether the left hippocampus could be spared. The invasive study showed the seizure origin in the tissue around the former CM but no epileptic discharges in the hippocampus. In a second operation, an anterior temporal resection was performed with removal of the epileptogenic surrounding tissue and the patient became seizure-free without cognitive deficits. The optimal surgical strategy for CM presenting with epileptic seizures must take into account various factors such as underlying mechanisms and duration of epilepsy, and location of the lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101430050004
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on tryptophan accumulation in brain during methiothepin-induced enhancement of 5-hydroxyindole synthesis (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 307 (1979), S. 143-149 
    Details
    ISSN: 1432-1912
    Keywords: Amino acid uptake ; 5-Hydroxyindole synthesis ; Indolectomy ; Methiothepin ; Serotonin ; Tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The elevation of brain tryptophan, 5-hydroxytryptophan and 5-hydroxyindoles (serotonin + 5-hydroxyindole acetic acid) that results from a tryptophan load is potentiated by prior administration of methiothepin, a serotonin receptor antagonist. Coadministration of valine with tryptophan attenuates these effects even in animals receiving methiothepin pretreatment. Administration of methiothepin and tryptophan to rats with widespread reduction of brain 5-hydroxyindole levels resulting from raphe lesions or 5,7-dihydroxytryptamine pretreatment still enabled brain tryptophan levels to rise considerably above the sum of increases found in animals receiving one or the other. Following transection of the spinal cord, the cranial portion still exhibited enhanced uptake of tryptophan and 5-hydroxyindole synthesis following methiothepin plus tryptophan treatment, however, both these events were absent in the caudal segment. Apparently, enhanced tryptophan uptake can proceed in the presence of minimal neuronal activity; however, when nerve impulse flow is eliminated, both 5-hydroxyindole synthesis and tryptophan uptake is impaired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498456
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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