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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 18 (1988), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The methylating agents, methyl dodecane sulphonate, methyl hexadecane sulphonate and methyl hexadec-3-cne sulphonate are strong skin sensitisers, cross-reactive with one another, in guinea pig adjuvant tests. Differences in potency are observed among these 3 compounds, and the possible reasons for this urn discussed. Isocugenol fails to elicit a sensitisation response when challenged onto guinea pigs sensitised to methyl dodecane sulphonate, indicating that the mechanism of isoeugenol sensitisation is not based on methyl transfer. It is proposed that, in skin sensitisation involving small haptenic groups, antigenic specificity is directed not against the haptenic groups but against portions of the carrier protein whose configuration has been modified as a result of the carrier-hapten reaction. This concept is supposed by published data on cross-reactivity patterns with enantiomeric pairs of a-methylene-y-butyrolactone derivatives.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 59 (1988), S. 1635-1637 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Using the fast ion diagnostic experiment technique, a neutral probe beam (NPB) can be aimed to inject tangent to a magnetic surface. The resultant ion orbit shifts, due to conservation of canonical toroidal angular momentum, can be measured with a multi-sight-line charge exchange analyzer to yield direct measurements of radial magnetic flux profiles, current-density profiles, the radial position of the magnetic axis, flux surface inner and outer edges, q profiles, and central-q time dependencies. An extensive error analysis was performed on previous PDX q measurements in circular plasmas and the resulting estimated contributions of various systematic effects are discussed. Preliminary results of fast ion orbit shift measurements at early times in indented PBX-M plasmas are given. Methods for increasing the absolute experimental precision of similar measurements in progress on PBX-M are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 32 (1992), S. 471-510 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The highly indented plasmas of the PBX-M tokamak experiment [Plasma Physics and Controlled Nuclear Fusion Research (IAEA, Vienna, 1989), Vol. 1, p. 97] have reached plasma regimes of both high volume-averaged beta (βt), and high-beta poloidal (βp), and show evidence of the suppression of external surface modes by the passive stabilizing system. Values of βt up to 4.0 I/aB (% MA/m T) with Ti(0)≈4 keV have been obtained. A magnetohydrodynamic analysis of plasmas with βp=2.0 indicates that these plasmas are near the threshold of the second stability regime. A value of βt of 6.8% has been reached with Ti(0)〉5 keV and an indentation of 28%. Control of plasma shape is accomplished with a feedback system that uses a moment expansion about a single equilibrium and is augmented by time-dependent waveforms to redefine plasma shape. Diagnostics to measure the safety factor q have been developed and used to make accurate measurements of q(r) and to verify changes made in q(0).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 61 (1990), S. 2914-2919 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The Stark effect has been employed in a novel technique for obtaining the pitch angle profile and q(r) using polarimetry measurements of the Doppler shifted Hα emission from a hydrogen diagnostic neutral beam. As a neutral beam propagates through a plasma, collisions of the beam particles with the background ions and electrons will excite beam atoms, leading to emission of radiation. The motional Stark effect, which arises from the electric field induced in the atom's rest frame due to the beam motion across the magnetic field (E=Vbeam×B), causes a wavelength splitting of several angstroms and polarization of the emitted radiation. The Δm=±1 transitions, or σ components, from the beam fluorescence are linearly polarized parallel to the direction of the local magnetic field when viewed transverse to the fields. Since the hydrogen beam provides good spatial localization and penetration, the pitch angle can be obtained anywhere in the plasma. A photoelastic modulator (PEM) is used to modulate the linearly polarized light. Depending on the orientation of the PEM, it can measure the sine or cosine of the angle of polarization. Two PEM's are used to measure both components simultaneously. Results of q(r) for both Ohmic and NBI heated discharges have been obtained in the Princeton Beta Experiment (PBX-M) tokamak, with an uncertainty of ∼6% for q(0).
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The motional Stark effect polarimetry technique has been used to measure the magnetic pitch angle in a variety of PBX-M plasma conditions. For high aspect ratio, circular plasmas, the q profile can be obtained directly from the γp profile using the cylindrical expression q(r)=(rBT/RBp). In strongly shaped PBX-M plasmas, the magnetic pitch angle data are used as an internal constraint on the plasma equilibrium calculated by solving the Grad–Shafranov equation, subject to external flux measurements. Thus, an accurate determination of q(r) depends upon detailed knowledge of the plasma equilibrium. Discussion of uncertainties in the equilibrium determination and their effect on q(r) will be presented. The equilibrium solutions using the pitch angle data are required for MHD stability calculations, which are being used to investigate the relationship between internal kink modes and plasma shape.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 68 (1961), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 84 (1977), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two patients who had previously been sterilized by the application of Hulka-Clemens spring-loaded clips to the Fallopian tubes, had a vaginal hysterectomy. In each patient a clip that was left attached to its tubal remnant was spontaneously extruded through the vaginal vault during the postoperative period.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 30 (1974), S. 0 
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Kharkov 22 M.C. winter wheat was grown continuously from seed under four temperature regimens; 2°C; 2°C then transferred to 20°C; 6°C, and 20°C. Plants were harvested at the 4-leaf stage (except the 2°C plants which were harvested at the 3-leaf stage) and the levels of endogenous gibberellins (GAs) were measured and their cold hardiness determined. The GA content of 20°C and the 6°C seedlings were about equal and greater (by 4- to 30-fold) than the GA content of 2°C seedlings that had been transferred to 20°C (i.e. vernalized). The GA content of the 2°C seedlings was least of all, being 28- to 320-fold less than the 20°C seedlings. At harvest the leaves of the 20°C seedlings were somewhat larger than those of the seedlings grown at 2°C and transferred to 20°C. The leaves of the 6°C seedlings were very much smaller and the leaves of the 2°C seedlings were smallest of all.It is concluded that while GAs may play a role in controlling leaf size and level of cold hardiness of wheat, they are not the most important factor.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 23 (1990), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: As part of the investigation of structure activity relationships in contact allergy, it has been shown that methyl transfer agents are capable of acting as skin sensitizers. This work has now been extended to a more general examination of alkyl transfer reactions. The modified single injection adjuvant test has been used to investigate the sensitization potential of C12, C16, and unsaturated C18 alkyl transfer agents. Dose responses to challenge and the patterns of cross-reactivity between these materials and methyl transfer agents have been studied. All alkyl transfer agents examined were potent sensitizers in the guinea pig. There was evidence of mutual cross-reactivity between all alkyl transfer agents examined (including methyl transfer agents). Analysis of the data in terms of a modified relative alkylation index showed evidence of an overload effect. The sensitization data has been accurately modelled using a mathematical equation. These results emphasize the possibilities for relating physicochemical parameters and skin sensitization potential. Further studies with alkyl transfer agents art in progress of amplify the observations and conclusions presented in this report. No in vitro model is available for the prediction of skin sensitization potential. Therefore approach based on a model using physicochemical criteria is the most likely route to a reduced requirement for animal testing.
    Type of Medium: Electronic Resource
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