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  • 1
    Electronic Resource
    Electronic Resource
    Influence of detergent washing powders on minimal eliciting patch test concentrations of nickel and chromium (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Minimum eliciting levels of nickel have been estimated in 25 nickel-sensitive subjects, and of chromium in 14 chromium-sensitive subjects by patch tests with aqueous solutions of the respective metals. The minimum level of each metal required to provoke a patch test reaction was considerably greater than that found in fabric washing powder solutions and was in the majority of patients tested of the order of 112 ppm nickel (0.05% nickel sulphate) or 885 ppm hexavalent chromium (0.25% potassium dichromate). One nickel-sensitive subject and one chromium-sensitive subject reacted to 1 ppm of the respective metal. Fabric washing powder did not significantly alter the patch test reaction to nickel sulphate or provoke reactions in nickel-or chromium-sensitive subjects. EDTA significantly reduced the number and severity of patch test reactions to nickel sulphate but not those to potassium dichromate or trivalent chromium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1983.tb04470.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A comparison of three guinea-pig sensitization procedures for the detection of 19 reported human contact sensitizers (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 7 (1981), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A maximization test (after Magnusson & Kligman 1970), a single injection adjuvant test (SIAT) and a modified Draize test procedure for assessing contact sensitization potential in guinea-pigs have been compared for their ability to detect 19 known human contact sensitizers. The results show that the modified Draize procedure is a good screening test particularly for strong sensitizers. The maximization procedure is a very stringent test of sensitization potential, able to detect some marginal sensitizers. The sensitivity of the SIAT procedure is sufficiently similar to that of the maximization test to act as an alternative for routine testing, particularly in view of its practical advantages over the maximization procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1981.tb04060.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Methyl groups as antigenic determinants in skin sensitisation (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 18 (1988), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The methylating agents, methyl dodecane sulphonate, methyl hexadecane sulphonate and methyl hexadec-3-cne sulphonate are strong skin sensitisers, cross-reactive with one another, in guinea pig adjuvant tests. Differences in potency are observed among these 3 compounds, and the possible reasons for this urn discussed. Isocugenol fails to elicit a sensitisation response when challenged onto guinea pigs sensitised to methyl dodecane sulphonate, indicating that the mechanism of isoeugenol sensitisation is not based on methyl transfer. It is proposed that, in skin sensitisation involving small haptenic groups, antigenic specificity is directed not against the haptenic groups but against portions of the carrier protein whose configuration has been modified as a result of the carrier-hapten reaction. This concept is supposed by published data on cross-reactivity patterns with enantiomeric pairs of a-methylene-y-butyrolactone derivatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1988.tb02807.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    IgE antibody levels to ingested soya protein determined in a normal adult population (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Levels of soya protein-specific IgE were measured in a normal adult population (seventy-four males, fifteen females) who ingested soya-containing and control diets during two 4-week periods. Increases in soya-specific IgE were observed for some individuals following ingestion of the soya-containing diet, and for the female group the increase in soya-specific IgE was statistically significant (P= 0·02). The increase of soya-specific IgE was small and led to lower levels than that associated with adverse effects. The increase in soya-specific IgE in the female group was accompanied by a significant increase (P= 0·02) in total immunoglobulin A. Changes in the level of soya-specific haemagglutinating antibody, soya-specific IgG, IgA and IgM as measured by ELISA and the immunoconglutinin titre could not be related to ingestion of the soya-containing diet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb03126.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    IgE antibodies to food allergens detected by ELISA, RAST and monkey PCA (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1983.tb02575.x
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  • 6
    Electronic Resource
    Electronic Resource
    RAST using crude and purified anti-IgE (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 6 (1976), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The sensitivity of the RAST using anti-IgE in 125I-labelled IgG fractions of sheep antiserum was compared to that using anti-IgE purified by immunosorbent techniques in tests with three allergens (grass pollens, Aspergillus fumigatus and the detergent enzyme ‘Alcalase’) on sera from 248 workers in a detergent factory. Both anti-IgE reagents measure the same antibody but the RAST procedure using the crude anti-IgE reagent is less sensitive than that using the immunosorbent-purified anti-IgE in its ability to detect circulating IgE in subjects with positive skin-prick tests. In general the agreement between positive RAST and positive skin test was improved when only skin tests equal to or greater than 3 mm were considered positive. With Alcalase, antigen non-specific binding by the crude anti-IgE reagent may give false positive results. Optimal conditions for the preparation of allergosorbents with this allergen are defined. Predictive equations relating the results of RAST and skin test show that the hitherto arbitrary definition of a positive RAST result is statistically valid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1976.tb01928.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Comparative serological and clinical findings in subjects exposed to environmental allergens (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 8 (1978), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serological tests of healthy atopic and non-atopic subjects were carried out during medical surveillance of 288 workers in detergent and food manufacturing factories in the same highly industrialized area. Correlations between the serological parameters and various aspects of the clinical history were compared for subgroups in these and control populations. The value of serological tests as aids in the diagnosis of allergic reactivity to the detergent enzyme Alcalase was given particular attention.There was no indication that employment in the detergent factory significantly increased the amount of serum total IgG, IgA or IgM. There was a positive correlation between the amount of serum total IgE and atopy as defined. The need for new standards of normality in the amount of serum total α1-antitrypsin in women receiving oral contraceptives was confirmed. No subjects had a homozygous deficiency of α1-antitrypsin.There was a statistically significant correlation between the level of allergen-specific antibody measured by the RAST and skin prick test weals of 3·0 mm diameter or greater, which were obtained using standardized skin prick test procedure and reagents. The significance of small skin prick test reactions has been evaluated critically.The results of various tests for allergen-specific precipitating antibodies indicated the need for caution in interpreting the results of such tests with allergens such as Alcalase, which contain several antigenic components. Alcalase-specific IgG antibodies were only detected in the sera of persons exposed to enzyme dusts in factories. They were evidence of exposure to the antigens, not of a clinical allergic response, and probably reflect the natural formation of antibody shown to occur with numerous environmental antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1978.tb00470.x
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    Paper (German National Licenses)
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