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  • Amphetamine  (2)
  • Amylobarbitone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The role of fentanyl training dose and of the alternative stimulus condition in drug generalization (1982)
    Springer
    Psychopharmacology 76 (1982), S. 149-156 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Drug generalization ; Fentanyl ; Morphine ; Amphetamine ; Nicotine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Different groups of rats were trained to discriminate fentanyl (F) (0.03, 0.02, or 0.01 mg/kg) from saline or to discriminate 0.03 mg/kg fentanyl (F) from alternative stimulus conditions (saline, 0.15 mg/kg nicotine, or 0.01 mg/kg F). When percentage of responses on the drug lever and percentage of time spent responding on the drug lever were used as dependent variables, it was found that training dose and alternative stimulus condition both affected the ED50 and the slope of the F generalization gradient. ED50 and slope values based on group data were not significantly different from values based on individual data. Differences between the results of the first and second 2.5-min period of the extinction test were not significant. ED50 and slope values were unaffected by the preceding training session, except in the group trained to discriminate 0.03 from 0.01 mg/kg F. A lever selection measure showed a significant effect of alternative stimulus condition on ED50 values only. Training dose and alternative stimulus condition also affected the generalization to morphine. Under none of the conditions explored in this study did generalization occur to amphetamine or nicotine. The results are discussed in terms of the relative nature of drug generalization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00435269
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Response repetition in pigeons: pharmacological and behavioral specificity (1986)
    Springer
    Psychopharmacology 90 (1986), S. 475-481 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Amphetamine ; Chlordiazepoxide ; Scopolamine ; Phencyclidine ; Pentobarbital ; Morphine ; Haloperidol ; Chlorpromazine ; Satiation ; Extinction ; Response repetition ; Response switching ; Pigeons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using a reinforcement schedule that arranges random sequences of reinforcements over two response keys, low and high probabilities of repetition of non-reinforced responses were generated in two groups of pigeons (n=3 per group) by varying the probability of reinforcement for responding on the key to which reinforcement was assigned. Unlike rats, the pigeons did not show a tendency to repeat just-reinforced responses, but showed a strong position bias, that was reduced by additional feeding and extinction, but not by any of the drug treatments. Apomorphine increased response repetition, irrespective of the control probability of repetition; d-amphetamine increased low probabilities of repetition, but decreased high probabilities. Chlordiazepoxide and scopolamine selectively decreased high probabilities of repetition; phencyclidine and pentobarbital selectively increased low probabilities of repetition. Morphine, haloperidol, chlorpromazine, additional feeding, and extinction did not affect repetition of non-reinforced responses. Extinction increased perseveration, whereas drug effects on perseveration were not observed. Drug-induced changes of patterning of responses as exemplified herein by drug-induced alterations of repetitiveness may be relevant to the interpretation of drug effects upon performance brought about by other behavioral processes such as discrimination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174064
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Habituation of the head-poke response: Effects of an amphetamine-barbiturate mixture, PLG and fenfluramine (1981)
    Springer
    Psychopharmacology 72 (1981), S. 251-256 
    Details
    ISSN: 1432-2072
    Keywords: dl-Amphetamine ; Amylobarbitone ; Drug mixture ; PLG ; Fenfluramine ; Habituation ; Exploratory response ; General activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A test situation was developed in which the effects of drugs on habituation of exploratory behavior (head-poke responses) could be assessed independently of their effects on general activity (locomotion and rearing). Habituation, spontaneous recovery from habituation and stimulus specificity of habituation were studied. An amphetamine-barbiturate mixture attenuated habituation of the head-poke response without influencing general activity. Pro-Leu-Gly-NH2 (PLG), an oxytocin fragment, increased locomotor activity and did not alter the course of habituation of the head-poke response. Since exploratory behavior and general activity can be pharmacologically dissociated in the test situation used, it is concluded that the test situation is suitable for studying the effects of drugs on habituation of exploratory behavior. The amphetamine-barbiturate mixture did not influence the stimulus specificity of habituation of the head-poke response. Fenfluramine however increased the effects of stimulus change on the head-poke response while not influencing habituation of this response. These results show that habituation and stimulus specificity of habituation of exploratory behavior can be pharmacologically dissociated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431825
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    Paper (German National Licenses)
    Fulltext
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