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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 399 (1983), S. 233-236 
    ISSN: 1432-2307
    Keywords: Amyloid ; Amyloidosis ; Lymph nodes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of a patient presenting with supraclavicular and cervical lymph node enlargement with demonstration of amyloid is presented. Histologic features are described. Amyloid deposition was not found in any other organ. Immunohistochemical typing with antisera raised against protein AA, Aλ, and Aκ showed a reaction only against Aλ. Thus, this case belongs to the immunoglobulin λ light chain-derived types that occur in many other parts of the body, particularly the respiratory tract.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 373 (1977), S. 303-309 
    ISSN: 1432-2307
    Keywords: Immunocytoma ; Malignant lymphoma, lymphoplasmacytoid ; Chronic lymphocytic leukemia ; Tissue mast cell count and distribution ; Differential diagnostic parameters in lymph node biopsies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amount and distribution of tissue mast cells in the three subtypes of immunocytoma (IC) were studied in lymph nodes of 58 cases and compared with the findings on 34 cases of chronic lymphocytic leukemia (CLL). There were significantly more mast cells in the lymphoplasmacytic and lymphoplasmacytoid subtypes of IC than in CLL. The median mast cell count for the polymorphic subtype of IC was also greater than that for CLL; however, this difference was not statistically significant. Tissue mast cells were diffusely distributed in the lymph nodes in IC, whereas they were chiefly located in the sinus in CLL. Moreover, the cells themselves and their granules were generally larger in IC. Increase in the number and altered distribution of the tissue mast cells in histological sections are therefore diagnostic aids for distinguishing IC from CLL.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 51 (1973), S. 389-396 
    ISSN: 1432-1440
    Keywords: B-cell lymphoma ; secretory lymphocytes ; defect of secretory mechanism ; cytoplasmic inclusions ; Russell bodies ; IgM ; macroglobulins ; 8 S-IgM-subunits ; polyacrylamid electrophoresis ; radio-immunoprecipitation technique ; single radial immuno-diffusion ; Chronische lymphatische Leukämie ; B-Zellenlymphom ; lymphatische Zellen vom sekretorischen Typ ; Sekretionshemmung ; intracelluläre Einschlüsse ; Russellsche Körperchen ; IgM ; Makroglobuline ; 8 S-IgM-Untereinheiten ; Polyacrylamidelektrophorese ; Radioimmunpräzipitationstechnik ; einfache radiale Immunodiffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem Fall von chronischer lymphatischer Leukämie wurden histologische, cytochemische und elektronenmikroskopische Untersuchungen des Lymphknotens sowie Immunglobulinbestimmungen des Lymphknotenhomogenates und des Blutes durchgeführt. Die Immunglobulinbestimmungen deckten eine hochgradige IgM-Vermehrung im Lymphknoten bei IgM-Verminderung im Blut auf. Ein morphologisches Äquivalent dieser IgM-Vermehrung stellte die Ablagerung PAS-positiver Cytoplasmaeinschlüsse in den neoplastischen Lymphknotenzellen dar. Diese Einschlüsse waren in Ergastoplasmasäcken dieser Zellen lokalisiert. Im übrigen beherrschten ergastoplasmahaltige „sekretorische“ lymphatische Zellen ohne cytoplasmatische Einschlüsse das elektronenmikroskopische Bild. Es handelte sich also um ein IgM-bildendes B-Zellenlymphom vom sekretorischen Typ. Die unterbliebene Abgabe der Makroglobuline in das Blut ist als Sekretverhaltung zu deuten. Da das IgM als 8 S-IgM im Gewebe vorlag, nehmen wir an, daß hier eine Polymerisationsstörung der IgM-Untereinheiten zu dem 19 S-Pentamer bestand, als deren Folge die unterbliebene Sekretion von IgM ins Blut anzusehen ist.
    Notes: Summary A lymph node of a patient suffering from chronic lymphocytic leukemia was investigated using histological, cytochemical and electron microscopic techniques. The remaining lymph node tissue and the blood were also examined for their immunoglobulin content. The immunoglobulin analysis revealed an excessive increase of IgM in the lymph node, while there was a reduced serum IgM level. A morphological equivalent of the increased IgM was constituted by the deposit of PAS-positive cytoplasm inclusions, which were embedded in distended cisternae of the ergastoplasm of the neoplastic lymph node cells. “Secretory” lymphatic cells containing ergastoplasm without inclusion bodies otherwise dominated the electron microscopic picture. The existence of a B-cell lymphoma producing IgM of the secretory type is thus demonstrated. The lack of emission of IgM into the blood has to be interpreted as the result of a defect in the secretory mechanism. As the IgM was found in the form of 8 S-IgM in the tissue, it can be assumed that a disturbance of the polymerisation of the IgM-subunits into the 19 S-pentamer existed, the result of which was the absence of secretion of IgM into the blood.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2307
    Keywords: Malignant and benign lymphoma ; Immunocytoma ; Centroblastic malignant lymphoma ; Castleman Tumor ; Eye, lid and orbit ; Histologic features
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Studie wurden 23 Lymphome der Augen-, Lid- und Orbitalregion ausgewertet. Sie stammten aus einem nicht ausgewählten bioptischen Untersuchungsgut des Pathologischen Instituts der Universität Kiel und des Lymphknotenregisters bei der Deutschen Gesellschaft für Pathologie. Es handelte sich dabei um 12 maligne und 11 benigne Lymphome. Die malignen Lymphome stellten jeweils Non-Hodgkin-Lymphome dar. Unter den letzteren fanden wir elfmal ein Immunocytom, ein malignes Lymphom mit niedrigem Malignitätsgrad — dagegen nur einen Fall eines malignen Lymphoms mit hohem Malignitätsgrad, ein centroblastisches Lymphom. Die Diagnose eines benignen Lymphoms wurde jeweils durch die von uns erhobenen katamnestischen Angaben bestätigt. Während sich das benigne Lymphom in 7 von 11 Fällen in der Conjunctiva entwickelt hatte, war dies bei nur 2 von 11 Fällen mit Immunocytom zu beobachten. Das Immunocytom stellt einen Tumor dar, der aus Lymphocyten und Plasmazellen oder plasmocytoiden Zellen besteht und meist PAS-positive globuläre Einschlüsse in Kern und/oder Cytoplasma der Plasma- oder plasmocytoiden Zellen aufweist.
    Notes: Summary Twenty-three lymphomas of the eye, eyelid, and orbit were chosen for study from biopsy material of the Department of Pathology, University of Kiel, and the Lymph Node Registry in Kiel. There were 12 malignant non-Hodgkin's lymphomas and 11 benign lymphomas. Catamnestic examination confirmed the histologic diagnosis in all 11 cases of benign lymphoma. Eleven of the malignant lymphomas represented immunocytomas and were therefore of low-grade malignancy. In contrast, there was only one case of malignant lymphoma of high-grade malignancy, which was diagnosed as centroblastic lymphoma. The immunocytoma was retrobulbar in one third of our cases and conjunctival in only 2 cases, whereas benign lymphoma had developed in the conjunctiva in 7 of 11 cases. Immunocytoma represents a tumor composed of lymphocytes and plasma cells or plasmacytoid cells. PAS-positive globular inclusions are usually found in the nucleus and/or cytoplasm of the plasma cells or plasmacytoid cells.
    Type of Medium: Electronic Resource
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