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  • 1
    Electronic Resource
    Electronic Resource
    Augmentation of impaired tumoricidal function in alveolar macrophages from lung cancer patients by cocultivation with allogeneic, but not autologous lymphocytes (1997)
    Springer
    Cancer immunology immunotherapy 45 (1997), S. 29-36 
    Details
    ISSN: 1432-0851
    Keywords: Key words Alveolar macrophages ; Tumoricidal activity ; PBL ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  It has been reported that the in vitro development of tumoricidal function in alveolar macrophages from lung cancer patients is reduced significantly when compared to that in peripheral blood monocytes from the same patients or alveolar macrophages from control patients. In the present investigation, a method for potentiating the development of tumoricidal function in alveolar macrophages from lung cancer patients is described. This method, which relies on priming the macrophages with purified, allogeneic peripheral blood lymphocytes from normal donors, could not be demonstrated when autologous lymphocytes from lung cancer patients were used in the priming coculture. The augmentation of tumoricidal function appears to be mediated by one or more soluble factors, since supernatants from cocultures of alveolar macrophages and allogeneic peripheral blood lymphocytes could enhance the cytotoxic function of freshly obtained alveolar macrophages. Furthermore, it appears that NK cells are necessary for this effect, since depletion of CD56+/CD57+ cells from allogeneic lymphocytes eliminated their capacity to enhance alveolar macrophage cytotoxic function. The augmentation of cytotoxic function elicited in alveolar macrophages by this method was not associated with changes in the secretion of tumor necrosis factor α, or interleukin 1β.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050397
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of tumoricidal function in alveolar macrophages from lung cancer patients by interleukin-6 (1997)
    Springer
    Cancer immunology immunotherapy 45 (1997), S. 37-44 
    Details
    ISSN: 1432-0851
    Keywords: Key words Alveolar macrophages ; Tumoricidal activity ; PBL ; Interleukin-6 ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previous studies have demonstrated that alveolar macrophages from lung cancer patients are impaired in their ability to develop tumoricidal function when stimulated by activators such as interferon γ + lipopolysaccharide. However, these same macrophages have been shown to develop significant tumoricidal function when precultured with macrophage-depleted allogeneic peripheral blood lymphocytes from normal donors, an effect that was lost by the elimination of natural killer cells from the allogeneic lymphocyte population. In the present study, the effect of each activation condition on the expression of mRNA for interleukin-1α (IL-1α), IL-1β, tumor necrosis factor α (TNFα) and IL-6 was determined using reverse transcription/polymerase chain reaction. The results show that the non-permissive activation condition is associated with the expression of mRNA for IL-6 while the permissive activation condition is not. Antibodies against IL-6 were subsequently shown to permit the development of tumoricidal function in alveolar macrophages stimulated with interferon γ + lipopolysaccharide while IL-6 protein was shown to inhibit the stimulatory action of allogeneic lymphocytes on the development of tumoricidal function in the same alveolar macrophages. Neither the permissive (i.e. allogeneic lymphocyte stimulation) nor the non-permissive (i.e. interferon γ + lipopolysaccharide) activation condition had any effect on the capacity of alveolar macrophages from lung cancer patients to express mRNA for IL-1α, IL-1β or TNFα. These results show that IL-6 can regulate the ability of alveolar macrophages from lung cancer patients to be stimulated by interferon γ + lipopolysaccharide to develop significant tumoricidal function. They also show that allogeneic lymphocytes have the capacity to down-regulate IL-6 mRNA synthesis by alveolar macrophages thereby permitting the development and/or expression of macrophage tumoricidal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050398
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of reappearance of fixated and attended stimuli upon saccadic reaction time (1990)
    Springer
    Experimental brain research 81 (1990), S. 318-324 
    Details
    ISSN: 1432-1106
    Keywords: Attention ; Fixation ; Saccadic reaction time Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of visual attention and fixation upon the distribution of saccadic latencies: express (E-), fast regular (FR-), and slow regular (SR-) saccades were investigated. Extinguishing a fixation or an attention point 200–300 ms before target onset increases the incidence of E-saccades while concurrently decreasing the proportion of SR-saccades. Since this extinction forces a disengaging of attention, these changes in relative proportions of saccades reflect the elimination of one of the steps involved in programming saccades. It is shown that a previously attended stimulus has a favored status relative to other stimuli in the visual field. If, after being turned off, the previously attended fixation point or a peripheral attention stimulus is turned on near the time of the target's appearance, the occurrence of the E-saccades is greatly reduced. However, the appearance of any other stimulus in the visual field at or near the time of the target onset does not inhibit E-saccades. Contrary to the conclusions reached by Posner and Cohen (1984), a stimulus presented at the formerly attended location can attract attention more efficiently than a stimulus presented at another, new location.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228122
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  • 4
    Electronic Resource
    Electronic Resource
    Relationship between directed visual attention and saccadic reaction times (1988)
    Springer
    Experimental brain research 73 (1988), S. 546-552 
    Details
    ISSN: 1432-1106
    Keywords: Attention ; Fixation ; Saccades ; Saccadic reaction times
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Saslow (1967) and Fischer and Ramsperger (1984) found that saccadic reaction time (SRT) depends on the interval between the fixation point offset and the target onset. Using a continuously visible fixation point, we asked whether a similar function would be obtained if subjects attended to a peripherally viewed point extinguished at variable intervals before or after the target onset. The interval was varied between -500ms (i.e., attention stimulus offset after saccade target onset = overlap trials) and 500ms (i.e., attention stimulus offset before saccade target onset = gap trials). The results show a constant mean SRT of about 240 ms for overlap trials, and a U-shaped function with a minimum of 140 ms, at a gap duration of 200 ms, for gap trials. These findings suggest that saccadic latencies do not depend on the cessation of fixation per se, but rather on the disengagement of attention from any location in the visual field. The time required for subjects to disengage their attention is approximately 100 ms. This disengaged state of attention — during which short latency (express) saccades can be made — can be sustained only for a gap duration of 300 ms. At longer gap durations mean SRTs increase again.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406613
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  • 5
    Electronic Resource
    Electronic Resource
    Analyse der Methylolmelamine durch Dünnschicht- und Gel-Chromatographie (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 294 (1979), S. 375-378 
    Details
    ISSN: 1618-2650
    Keywords: Analyse von Methylolmelaminen ; Chromatographie, Dünnschicht/Chromatographie, Gel ; Melamin-Formaldehyd-Harze
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die dünnschicht-chromatographische Trennung der verschiedenen Methylolmelamine kann man durch Verwendung von DMF/H2O/ CHCl3/Isopropanol (im Volumenverhältnis 1∶1∶1∶3) als Fließmittel und Cellulose als Sorptionsmittel verbessern. Gel-chromatographisch lassen sich mit Sephadex LH 20 als stationärer Phase und DMF als Elutionsmittel die meisten Methylolmelamine als gut erkennbare Peaks trennen, so daß man anhand der Gel-Chromatogramme die Verteilung der Methylolierungsprodukte und den Verlauf der Methylolierung von Melamin verfolgen kann.
    Notes: Summary Thin-layer Chromatographic separation of the different methylolmelamines can be improved by applying DMF/H2O/CHCl3/isopropanol (1∶1∶1∶3 by volume) as eluting solvent and cellulose as layer material. Using Sephadex LH 20 as stationary phase and DMF as eluent the gel-permeation chromatographic separation of different methylolmelamines can be achieved. The distribution of the initial reaction products of melamine and formaldehyde and the course of the methylolization reaction can be observed by gelpermeation chromatograms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00468526
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  • 6
    Electronic Resource
    Electronic Resource
    Ozoninduzierter Abbau von Polyoxymethylen (1988)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 156 (1988), S. 123-137 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Samples of polyoxymethylene (unstabilized and stabilized with the antiozonants N-isopropyl-N′-phenyl-p-phenylenediamin (IPPD) and bis-(1,2,3,6-tetrahydrobenzaldehyd)pentaerithritylacetal (Vulkazon AFS)) were ozonized under mechanical load in a special climate chamber. Surface damages were determined by IR-spectroscopy and scanning electron microscopy. During the ozonolysis a damaged layer is formed, the thickness of which increases with increasing time of ozonization. During this damaging reaction acetal groups are attacked and oligomers are formed.
    Notes: Proben von unstabilisiertem und mit den Antiozonantien N-Isopropyl-N′-phenyl-p-phenylendiamin (IPPD) und Bis-(1,2,3,6-tetrahydrobenzaldehyd)-pentaerithrityl-acetal (Vulkazon AFS) stabilisiertem Polyoxymethylen wurden unter mechanischer Belastung in einer Klimakammer ozonisiert. Die Schädigungen auf der Oberfläche wurden IR-spektroskopisch und rasterelektronenmikroskopisch untersucht. Während der Ozonisierung von POM bildet sich eine geschädigte Schicht, deren Dicke mit zunehmender Ozonisierungszeit wächst. Hierbei wird das Polymere an den Acetalbindungen angegriffen, wodurch Ketten gespalten werden und Oligomere entstehen.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1988.051560111
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  • 7
    Electronic Resource
    Electronic Resource
    Strain-induced crystallisation and miscibility behaviour of hydrogenated nitrile rubbersPaper presented at the meeting of the GDCh-Fachgruppe “Makromolekulare Chemie” on “Kautschukelastische Polymersysteme” in Bad Nauheim (Germany), March 30-31, 1992. (1992)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 202 (1992), S. 143-158 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: HNBR rubbers, which are made by selective hydrogenation of the olefinic bonds of NBR rubbers, have been developed, because they show improved resistance towards heat and chemicals. In this study, two other properties are discussed that arise from the fact that HNBR rubbers are fairly alternating copolymers of unpolar butylene and polar acrylonitrile units: At intermediate compostions, HNBR rubbers form homogeneous blends with PVC, and near the symmetric composition they exhibit strain-induced crystallisation. The thermal transitions of the HNBR rubbers and their miscibility with PVC were analyzed, as well as the crystallisation and the stress-strain behaviour of a HNBR of symmetric composition.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1992.052020109
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  • 8
    Electronic Resource
    Electronic Resource
    Mutual miscibility of chlorinated hydrocarbon polymers derived from polyethylene and polyvinylchlorideDedicated to Prof. Dr. Dr. h. c. H. Hellmann on the occasion of his 75th birthday (1989)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 171 (1989), S. 53-63 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Untersucht wurde die Verträglichkeit von polymeren Chlorkohlenwasserstoffen mit verschiedener Comonomersequenzordnung. Eine erste Copolymerenserie (“PVCx”) wurde durch Reduktion von Polyvinylchorid hergestellt, eine zweite Serie (“PECx”) durch Chlorieren von Polyethylen. Die Polymer-Legierungen PECx/PECy, PVCx/PVCy und PVCx/PECy wurden bei 30°C und 110°C mit einer Lösungsfilmmethode analysiert. Im System PECx/PECy nimmt die Mischbarkeit mit steigendem Chlorgehalt der Copolymeren stetig zu. Bei den Systemen PVCx/PVCy und PVCx/PECy zeigt sich im Bereich um x = 1 eine erhöhte Tendenz zur Phasenseparation, die auf die bessere Comonomersequenzordnung der Copolymeren PVCx zurückzuführen ist. Im letzteren System ist diese Tendenz so stark, daß Polyvinylchlorid (PVCx=1) sogar mit dem chlorierten Polyethylen PECx=1, das die gleiche Bruttozusammensetzung hat, nicht mischbar ist.
    Notes: The compatibility of chlorinated hydrocarbon polymers of two different comonomer sequence orders was investigated. One series of copolymers (“PVCx”) was prepared via reduction of polyvinylchloride, the other (“PECx”) via chlorination of polyethylene in solution. The blends PECx/PECy, PVCx/PVCy and PVCx/PECy were analyzed with a film casting method at 30°C and 110°C. Miscibility increases in the system PECx/PECy steadily in the direction of increasing chlorine content. Due to the comonomer sequence order in the copolymers PVCx the systems PVCx/PVCy and PVCx/PECy show in the range around x = 1 an extra effect favouring phase separation. In the latter system this effect is so strong that polyvinylchloride (PVCx = 1) is even incompatible with the chlorinated polyethylene PECx=1 although both have the same overall composition.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1989.051710104
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  • 9
    Electronic Resource
    Electronic Resource
    Polyesters with 1.4:3.6-dianhydrosorbitol as polymeric plasticizers for PVCDedicated to Professor Dr. W. Heitz on the accasion of his 60th birthday (1992)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 199 (1992), S. 191-205 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Gesättigte aliphatische Polyester mit dem aus Stärke erhältlichen 1.4:3.6-Dianhydrosorbit wurden mit PVC gemischt. Die mechanischen Eigenschaften dieser Mischungen wurden mittels Differentialkalorimetrie, Spannungs-Dehnungs-Experimenten und Torsionspendelmessungen untersucht. Polyester mit mehr als vier Methylengruppen in der Säurekomponente sind mit PVC mischbar. Mischungen aus PVC und Poly(1.4:3.6-dianhydrosorbitadipat) sind dagegen unverträglich; sie zeigen für jedes Mischungsverhältnis zwei Glastemperaturen, die bei denen der Reinkomponenten liegen.
    Notes: Saturated aliphatic polyesters with 1.4:3.6-dianhydrosorbitol units were mixed with poly(vinylchloride) (PVC). The mechanical properties of these mixtures were examined by differential scanning calorimetry, stress-strain experiments, and torsion pendulum measurements. Polyesters containing more than four methylene groups in the acid component are compatible with PVC. These polyesters can serve as plasticizers for PVC. On the contrary, mixtures of PVC with poly(1.4:3.6-dianhydrosorbitol adipate) are incompatible; in this case, at any blend composition, the two glass transition temperatures of the pure components are observed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1992.051990115
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  • 10
    Electronic Resource
    Electronic Resource
    Grafting of polyesters by free-radical chain transfer (1993)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 210 (1993), S. 173-196 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Durch radikalische Kettenübertragung ausgelöste Pfropfcopolymerisationen von Polyestern rnit Styrol wurden untersucht. Als Rückgratkette diente ein Modellpolyester aus trans- 1,4-Cyclohexandiol und Sebacinsäuredichlorid. Ferner wurden flüssigkristalline Polyester rnit 1,4 : 3,6-Dianhydrosorbit und 1,4-Anhydroerythrit als Diolkomponenten hergestellt und zur Pfropfcopolymerisation mit Styrol eingesetzt. Polymerblends aus Tetramethylbisphenol A-Polycarbonat und den ungepfropften sowie mit Styrol gepfropften flüssigkristallinen Polyestern wurden durch gemeinsame Fällung von Polymerlösungen erhalten; ihr Verhalten wurde mit Torsionspendelmessungen, dynamisch-mechanischer Thermoanalyse und Elektronenmikroskopie untersucht. Der gepfropfte Polyester erwies sich dabei als wirksamer Phasenvermittler.
    Notes: Graft copolymerizations of polyesters with styrene by free-radical chain transfer reactions were investigated. A model polyester of trans-l,4-cyclohexanediol and sebacoy1 dichloride was used as backbone chain. The graft products were characterized. Furthermore, liquid crystalline polyesters with 1,4 : 3,6-dianhydrosorbitol and 1,4-anhydroerythritol as diol components were synthesized and used in graft copolymerizations with styrene. Polymer blends of tetramethylbisphenol A polycarbonate and the LC-polyester with and without polystyrene grafts were prepared by common precipitation of polymer solutions and their behaviour was examined by torsion pendulum, dynamic-mechanical thermoanalysis and scanning electron microscopy. The grafted polyester turned out to be an efficient phase compatibilizer.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1993.052100114
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