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  • Ultrastructure  (2)
  • Analytical Chemistry and Spectroscopy  (1)
  • CNS stimulants  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Identification and quantitative analysis of phendimetrazine and some of its metabolites in biological fluids (1986)
    Springer
    Monatshefte für Chemie 117 (1986), S. 1047-1055 
    Details
    ISSN: 1434-4475
    Keywords: Amphetamins ; Anorectics ; Antiobesity ; CNS stimulants ; Phendimetrazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Nach oralen Dosen von Phendimetrazin an Menschen wurde im Harn unverändertes Phendimetrazin, der N-demethylierte Metabolit, Phenmetrazin und das N-Oxid von Phendimetrazin, nicht jedoch N-Hydroxyphenmetrazin gefunden; die Metaboliten wurden mittels TLC und GLC identifiziert. Die Stabilität von Phendimetrazin und dessen Metaboliten wurde in biologischen Flüssigkeiten und in Ether untersucht. Es wurde eine gaschromatographische Methode für die quantitative Bestimmung von Phendimetrazin, seinem N-Oxid und Phenmetrazin in Harn, Plasma und Speichel entwickelt, wobei das N-Oxid vor der Analyse reduziert wurde.
    Notes: Abstract In urine, after oral doses of phendimetrazine to man, were found unchanged drug, the N-demethylated metabolite, phenmetrazine, and the N-oxide of phendimetrazine, but not N-hydroxyphenmetrazine; the metabolites were identified using t.l.c. and g.l.c. The stability of the drug and its metabolites in biological fluids and in ether was studied. A gas chromatographic procedure for the quantitative determination of unchanged drug, its N-oxide and phenmetrazine in urine, plasma and saliva was developed, the N-oxide being reduced before analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811275
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure and behaviour of the spindle pole body of the aphid-pathogenic fungusErynia neoaphidis (1984)
    Springer
    Protoplasma 120 (1984), S. 61-71 
    Details
    ISSN: 1615-6102
    Keywords: Fungus ; Spindle pole body ; Entomophthoraceae ; Erynia neoaphidis ; Ultrastructure ; Replication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A detailed account of the ultrastructure and behaviour of the spindle pole body (SPB) of the entomophthoraceous fungusErynia neoaphidis is presented for the first time. The SPB consists of extranuclear (ENC) and intranuclear (INC) components. The ENC is a “saucepan-shaped” structure which lies in a pocket of the nuclear envelope. It is composed of a forked, fibrillar “handle” and a shallow, cylindrical “pan”. The “pan” has a wall of two layers, both of which are thickened with a regular periodicity so that they appear to be “beaded”. It is postulated that the “pan“ is formed from rough endoplasmic reticulum and that it synthesizes the amorphous, electron-dense material coating the ENC. The INC is a “saucer-shaped”, electron-dense plaque in which the ends of the spindle microtubules terminate. During metaphase, a “clear zone” separates the INC from the nuclear envelope and persists until telophase. The roles of the amorphous, electron-dense material and the “clear zone” as well as the method of SPB replication are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287618
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of mitosis in the aphid-pathogenic fungusErynia neoaphidis (1984)
    Springer
    Protoplasma 120 (1984), S. 72-83 
    Details
    ISSN: 1615-6102
    Keywords: Fungus ; Mitosis ; Entomophthoraceae ; Erynia neoaphidis ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An account of mitosis in the aphid-pathogenic, entomophthoraceous fungusErynia neoaphidis is presented. The mitotic apparatus is characterized by a closed, intranuclear, polarized spindle. Chromosomes are permanently attached by kinetochore microtubules (kcMTs) to the poles during mitosis. The spindle develops as the spindle pole bodies migrate and separate. At metaphase the eccentric spindle contains only kcMTs and is located in a relatively chromatinfree zone. Paired sister kinetochores are arranged in a broad metaphase plate. During anaphase kcMTs shorten, astral and nonchromosomal microtubules develop and elongate and the interpolar distance increases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287619
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  • 4
    Electronic Resource
    Electronic Resource
    A re-examination of the synthesis and some properties of the in vitro metabolite, N-hydroxyphenmetrazineAbbreviation: CPBA = m-chloroperbenzoic acid. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 137-141 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reported synthesis of N-hydroxyphenmetrazine from phenmetrazine by the action of m-chloroperbenzoic acid could not be repeated. When the synthetic procedure was modified N-hydroxyphenmetrazine was obtained in low yield. The product had different properties from those claimed previously, but was identical to metabolically produced N-hydroxyphenmetrazine. It was characterized by means of thin-layer chromatography, combined gas chromatography and mass spectrometry, preparation of a t-butyldimethylsilyl derivative and oxidation to a mixture of nitrones. Mass spectrometry was also used to characterize these derivatives.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020307
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