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  • Chemistry  (49)
  • Analytical Chemistry and Spectroscopy  (6)
  • chemotherapy  (4)
  • Lycopersicon esculentum  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Postinfectional changes of lipids and photosynthesis in Lycopersicon esculentum susceptible to Phytophthora capsici
    Amsterdam : Elsevier
    Plant Science 61 (1989), S. 169-178 
    Details
    ISSN: 0168-9452
    Keywords: Lycopersicon esculentum ; Phytophthora capsici ; chlorophylls ; fatty acids ; photosynthesis ; plant-pathogen interaction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9452(89)90221-5
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  • 2
    Electronic Resource
    Electronic Resource
    Polar lipids in healthy and Phytophthora capsici-infected leaflets of Lycopersicon esculentum
    Amsterdam : Elsevier
    Phytochemistry 31 (1992), S. 1961-1967 
    Details
    ISSN: 0031-9422
    Keywords: Lycopersicon esculentum ; Phytophthora capsici ; Solanaceae ; fatty acids ; glycoglycerolipids ; oomycete ; phospholipids ; plant-pathogen interactions ; polar lipids.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(92)80342-C
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  • 3
    Electronic Resource
    Electronic Resource
    Pigment evolution in Lycopersicon esculentum fruits during growth and ripening
    Amsterdam : Elsevier
    Phytochemistry 14 (1975), S. 2357-2362 
    Details
    ISSN: 0031-9422
    Keywords: Lycopersicon esculentum ; Solanaceae ; carotenoids ; chlorophylls. ; maturation ; plastids ; tomato fruit
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(75)80344-X
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  • 4
    Electronic Resource
    Electronic Resource
    Sixteen week dose intense chemotherapy for inoperable, locally advanced breast cancer (1993)
    Springer
    Breast cancer research and treatment 28 (1993), S. 277-284 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; chemotherapy ; dose-intensity ; inflammatory breast cancer ; locally advanced breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Up to 15% of women with breast cancer have locally advanced disease at diagnosis. The poor response of these patients to local therapy alone and the frequent development of disseminated disease suggest that early intensive systemic therapy may benefit these women. Twenty-four patients with non-metastatic, locally advanced, primarily inflammatory, inoperable breast cancer were treated with a 16-week dose-intense chemotherapy regimen as induction therapy. Treatment consisted of 8 repetitive 2-week cycles consisting of 100 mg/m2 cyclophosphamide orally D1-7, 40 mg/m2 doxorubicin intravenously (IV) D1, 1 mg vincristine IV D1, 100 mg/m2 methotrexate IV D1, 10 mg/m2 leucovorin every 6 hours for six oral doses D2-3, and 600 mg/m2 5-FU IV over 2 hours D2. A continuous infusion of 300 mg/m2 5-FU per day was given IV D8-9 of each 2-week cycle. After induction all patients had at least a partial clinical response and were operable; 9/24 (37%) achieved a clinical complete response. All patients underwent at least a simple mastectomy. Pathologic examination revealed no evidence of gross macroscopic tumor in 11/24 patients (46%) and no evidence of microscopic disease in 4/24 patients (17%). Seven of 24 patients (29%) had no microscopic disease in the breast. At a median follow-up of 45 months, there have been 10 relapses in the 24 patients treated with this induction regimen. The actuarial relapse-free survival at 5 years is 58%. Actuarial overall survival at 5 years is 75%. We conclude that this regimen is safe and well-tolerated and that the results of this therapy are sufficiently promising to warrant further study of this regimen in patients with locally advanced breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00666589
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  • 5
    Electronic Resource
    Electronic Resource
    A scanning tunneling microscope study of single crystal polyethylene (1990)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 28 (1990), S. 399-410 
    Details
    ISSN: 0887-6258
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The scanning tunneling microscope has been used to image single crystal polyethylene lamellae coated with thin Au or Cr overlayers. The images show a variety of different morphologies ranging from single crystal lamella resting on atomically flat, highly oriented pyrolitic graphite substrates to large pyramidal structures formed by a multilayer growth process. Small outgrowth structures were observed on the top surface of many individual lamellae and were found to be in registry with the edge of the underlying “seed” lamella. The STM studies show evidence for sectorization of the single crystal lamella as well as plastic deformation of overlapping lamellae involving c-axis slip.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1990.140281302
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  • 6
    Electronic Resource
    Electronic Resource
    Matrix-assisted laser desorption/ionization mass spectrometry: Improved matrix for oligosaccharides (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 809-814 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The aim of this article was to study the influence of different matrix molecules on the quality of matrix-assisted laser desorption/ionization mass spectra of oligosaccharides. An important criterion was the sample preparation, i.e. the crystallization process leading to the matrix from which the analytes were desorbed and investigated. Quality criteria were, among others, the resulting molecular peak intensity, the mass resolution, and the suppression of unwanted matrix peaks. It was found that a mixture of 2,5-dihydroxy benzoic acid (DHB) and 1-hydroxy isoquinoline (HIC) in a weight ratio of 3:1 was best suited for the analytical investigation of oligosaccharides. In addition, this matrix mixture was found to be quite tolerant against all kinds of buffers, salts, and even additives such as sodium dodecyl sulfate (SDS). Furthermore, we determined the different affinities of the alkaline metals to the carbohydrates and found that cesium and potassium ions ionize oligosaccharides about three times better than sodium ions and therefore have an important influence on the quantum yield.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290090919
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  • 7
    Electronic Resource
    Electronic Resource
    Ion exchange and purification of carbohydrates on a Nafion®Trademark of Du Pont. membrane as a new sample pretreatment for matrix-assisted laser desorption/ionization mass spectrometry (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1031-1034 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A Nafion membrane was tested as a new tool for a fast and easy sample pretreatment for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) measurements. This membrane material was used for ion exchange and carbohydrate purification with minimal quantities of sample solution. An ion exchange method for carbohydrates was developed and demonstrated on a Dextran sample. The cations of the original sample were replaced within minutes by potassium or cesium ions. Another feature of this membrane was the fact that proteins and peptides adsorb on the acid surface. This behavior was investigated as a purification step for carbohydrates with high peptide and protein impurity concentrations. It was found that oligosaccharide libraries from rat- and mouse IgG mass spectra can be obtained clearly in the presence of high peptide impurities.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290091112
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  • 8
    Electronic Resource
    Electronic Resource
    Fatigue fracture of reaction injection molded (RIM) nylon composites (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 37 (1989), S. 3029-3056 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: This study was undertaken to determine how milled glass fibers affect the fatigue resistance of reaction injection molded (RIM) nylon 6. Specifically the effects of glass content, fiber length, orientation, and surface treatment were investigated. The fatigue crack growth rates for unfilled and glass-filled samples were observed to follow the well-known Paris equation in terms of dependence on cyclic stress intensity factor. For the unfilled nylon a line shaped zone was observed in advance of the crack tip. Fractography results suggest that the zone was the projection of the actual crack tip profile through the thickness of the sample rather than a distinct plastic or deformation zone. The fatigue fracture surface exhibited a patchy type structure with features 50-150 μm in size, suggesting a void coalescence type of mechanism as has been reported for injection molded nylons. A diffuse damage zone, several millimeters in size, was observed at the crack tip for the glass-filled RIM nylon 6. The zone was observed to pulsate with the applied oscillating load. The growth of the damage zone volume with increasing crack length (and thus increasing stress intensity factor range) followed the Paris law, as did the crack growth rate data. The damage mechanism is attributed to void formation and microcracking at the fiber-matrix interface. The results of this study show that, for milled glass-reinforced RIM nylon 6, the crack growth rates were much more rapid than observed for injection-molded nylon 6 containing chopped glass fibers. This difference is attributed to the greatly reduced glass fiber lengths for the milled glasses.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1989.070371019
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  • 9
    Electronic Resource
    Electronic Resource
    Phase II study of cisplatin and 5‐fluorouracil in previously treated metastatic breast cancer: an Eastern Cooperative Oncology Group study (PA 185) (1999)
    Springer
    Breast cancer research and treatment 57 (1999), S. 201-206 
    Details
    ISSN: 1573-7217
    Keywords: chemotherapy ; cisplatin ; 5‐fluorouracil ; metastatic breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The present study was conducted to investigate the efficacy and toxicity of a cisplatin and 5‐fluorouracil (5‐FU) combination in previously treated advanced breast cancer. Methods: Thirty‐six women with recurrent metastatic breast cancer were entered on a phase II study of 5‐FU 1000 mg/m2/day given intravenously as a continuous infusion on days 1–3 and cisplatin 30 mg/m2/day given intravenously over 1 h on days 2–4, repeated every 21 days. All subjects had received one previous chemotherapy regimen for metastatic disease and either progressed during treatment or relapsed after responding to previous chemotherapy. Fourteen patients had also received previous adjuvant chemotherapy, 17 patients had previous radiation therapy, and 29 patients had previous hormonal therapy. Results: Among 32 response‐evaluable patients, there were 10 partial remissions (31%) and 1 complete remission (3%), with an overall objective response rate of 34%. Median duration of response was 4 months. Median survival was 10.5 months for responders and 9.5 months for the entire group. Toxicity was mild to moderate in most patients. Overall twelve patients experienced grade 3 toxicity (10 hematologic, 1 mucositis, and 2 nausea). There were no grade 4 or 5 toxicities. Conclusion: Infusional cisplatin and 5‐FU is a well tolerated and active regimen in women with previously treated advanced breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006229701954
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  • 10
    Electronic Resource
    Electronic Resource
    Treatment of stage III breast cancer (1989)
    Springer
    Breast cancer research and treatment 13 (1989), S. 225-235 
    Details
    ISSN: 1573-7217
    Keywords: chemotherapy ; combination therapy ; hormonal synchronization ; locally advanced breast cancer ; preoperative chemotherapy ; prognosis ; radiotherapy ; staging, surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A major question in oncology today concerns the most appropriate therapy for locally advanced breast cancer. Realistic goals include effective local treatment and a prolonged disease-free interval for these patients, most of whom have incurable disease. Here, our panel discusses the roles of surgery, radiation therapy, chemotherapy, and hormonal therapy, and the proper sequencing of these modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106572
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