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  • Analytical Chemistry and Spectroscopy  (3)
  • WAF1/CIP1  (2)
  • HLA class II alleles  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY) (1996)
    Springer
    Diabetologia 39 (1996), S. 807-812 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin-dependent diabetes mellitus ; HLA class II alleles ; newborn screening ; autoimmunity.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autoimmunity causing insulin-dependent diabetes mellitus (IDDM) begins in early childhood due to interactions between genes and unknown environmental factors that may be identified through follow-up of a large cohort of genetically susceptible children. Such a cohort has been established using a simple and rapid cord blood screening for HLA alleles. The DRB1 and DQB1 second exon sequences were co-amplified using the polymerase chain reaction and hybridized with single and pooled sequence-specific oligonucleotide probes. Four individual probes were used to detect the susceptibility alleles DRB1*03, DRB1*04, and DQB1*0302 as well as the usually protective DRB1*15/16 (DR2) alleles. In addition, pooled probes allow the distinction of DR3/3 from the DR3/x genotype (where x is neither DR2, 3, nor 4) and DR4/4 from DR4/x. Among 5000 newborns from the general Denver population, we have found the high-risk genotype (DRB1*03/DRB1*04, DQB1*0302) to be present in 2.4 % of non-Hispanic whites, 2.8 % of Hispanics, and 1.6 % of African Americans. The moderate-risk genotypes (DRB1*04, DQB1*0302/DRB1*04, DQB1*0302, DRB1*04, DQB1*0302/x, or DRB1*03/DRB1*03) are present in 17 % of American non-Hispanic whites, 24 % of Hispanics and in 10 % of African Americans. These results demonstrate the feasibility of a large-scale newborn screening for genes associated with IDDM. The ultimate role for such a screening in future routine prediction and prevention of IDDM will depend on the availability of an effective and acceptable form of clinical intervention. [Diabetologia 1996) 39: 807–812]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050514
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 143-147 
    Details
    ISSN: 1432-1440
    Keywords: Induction ; p53 ; WAF1/CIP1 ; CLL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The treatment of chronic lymphocytic leukemia includes the use of alkylating agents, steroids, and more recently nucleoside analogues. While prior studies have described potential mechanisms of 2-chlorodeoxyadenosine cytotoxicity including the accumulation of DNA strand breaks and induction of apoptosis or programmed cell death, the expression of p53 and its downstream target WAF1/CIP1 have not been examined. In this report we describe the induction of p53 and WAF1/CIP1 in the apoptotic chronic lymphocytic leukemia cells after exposure to 2-chlorodeoxyadenosine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575446
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 143-147 
    Details
    ISSN: 1432-1440
    Keywords: Key words Induction ; p53 ; WAF1/CIP1 ; CLL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The treatment of chronic lymphocytic leukemia includes the use of alkylating agents, steroids, and more recently nucleoside analogues. While prior studies have described potential mechanisms of 2-chlorodeoxyadenosine cytotoxicity including the accumulation of DNA strand breaks and induction of apoptosis or programmed cell death, the expression of p53 and its downstream target WAF1/CIP1 have not been examined. In this report we describe the induction of p53 and WAF1/CIP1 in the apoptotic chronic lymphocytic leukemia cells after exposure to 2-chlorodeoxyadenosine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575446
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The reactive states of ions: Octatrienes and dimethyl substituted cyclohexadienes (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1975), S. 1075-1083 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The principal decomposition routes of molecular ions of cis, cis, cis-2,4,6-octatriene, cis, cis, trans-2,4,6-octatriene, trans, cis, trans-2,4,6-octatriene, trans-5,6-dimethyl-1,3-cyclohexadiene and cis-5,6-dimethyl-1,3-cyclohexadiene were studied using ion kinetic spectroscopy. The loss of radicals from [M]+· appears to proceed via a ground state, while loss of a neutral molecule appears to involve either complete equilibration of structure within the system or both ground state and excited state pathways.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210101205
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  • 5
    Electronic Resource
    Electronic Resource
    Ionic dehydration reactions: The effect of location of the activated complex on kinetic energy release (1977)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 12 (1977), S. 258-260 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A broad range of kinetic energy release has been found for the 1,4 elimination of water in a series of ortho substituted benzyl alcohols and benzoic acids. It is suggested that the trend reflects, in part, the position of the activated complex on the reaction coordinate. More specifically, reactions which proceed via an ‘early’ transition state release only small quantities of energy, whereas those processes occurring ‘later’ release a larger fraction of the available energy. Consequently, the o- methyl derivatives give large kinetic energy release compared to o- amino or hydroxy substituted compounds. Father verification is obtained from the small kinetic energy release observed for the 1,4 ionic dehydration in simple,acyclic alcohols.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210120415
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  • 6
    Electronic Resource
    Electronic Resource
    Ion structural studies by ion kinetic energy spectrometry: [C7H7]+, [C7H8]+·, [C7H7OCH3]+· (1973)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 7 (1973), S. 1303-1312 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The use of kinetic energy release measurements in the structural characterization of ions formed in the mass spectrometer and in the determination of fragmentation mechanisms is demonstrated. In combination with information on the mode of energy partitioning in some of these reactions this allows the following conclusions: (i) The metastable [C7H8]8· ions formed from toluene, cyclohepatatriene, n-butylbenzene, the three methyl anisoles, methyl tropyl ether and benzyl methyl ether all undergo loss of H· from a common structure. (ii) The metastable [C7H7]+ ions generated from the same sources and from benzyl bromide, benzyl alcohol, p-xylene and ethylbenzene appear to undergo loss of acetylene from both the benzylic and the tropylium structures. (iii) The metastable [C7H7OCH3]+· ether molecular ions undergo loss of CH3· by two types of mechanism, simple cleavage to give the aryloxy cation (not observed for benzyl methyl ether) and a rearrangement process which appears to lead to protonated tropone as the product. (iv) Loss of formaldehyde from the metastable [C7H7OCH3]+· molecular ions involves hydrogen transfer via competitive 4- and 5-membered cyclic transition states in the case of the anisoles and in the case of methyl tropyl ether, while for benzyl methyl ether, hydrogen transfer in the nonisomerized molecular ion occurs via a 4-membered cyclic transition state to yield the cycloheptatriene molecular ion.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210071110
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