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  • 1
    Electronic Resource
    Electronic Resource
    Reduced inhibitory activity of uronic-acid-rich protein in urine of stone formers (1994)
    Springer
    Urological research 22 (1994), S. 257-260 
    Details
    ISSN: 1434-0879
    Keywords: Calcium oxalate crystallization ; Nephrolithiasis ; Uronic-acid-rich protein ; Glycosaminoglycans ; Chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We recently reported that human urine contains a newly identified urinary glycoprotein acting as a potent inhibitor against calcium oxalate crystallization. This inhibitor is a uronic-acid-rich protein (UAP) with a molecular weight of approximately 35 kDa. In the present study, UAP was isolated from urine of stone formers and of subjects without a stone history, and its inhibitory activity was tested in a calcium oxalate crystallization system in vitro. Our results show a weaker inhibitory activity of UAP extracted from the urine of stone formers than that extracted from the urine of healthy subjects. Preliminary analyses of amino acid and carbohydrate content showed some differences between the two groups. The main difference was the reduction in sialic acid in UAP isolated from the urine of stone formers. We suggest that UAP contributes significantly to total urinary inhibitory activity of calcium oxalate crystallization and that the decrease in this activity in the urine of recurrent stone formers is due, in part, to the weak inhibitory activity of UAP. A structural abnormality of UAP could explain the diminution of its inhibitory activity in the urine of stone formers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541903
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Parenteral nutrition and repeated hemodialysis of bilaterally nephrectomized conscious dogs (1980)
    Springer
    Research in experimental medicine 178 (1980), S. 71-74 
    Details
    ISSN: 1433-8580
    Keywords: Parenteral nutrition ; Anephric dog ; Hemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To realize equilibrated metabolic conditions after bilateral Nx, three male mongrel dogs were exclusively fed by parenteral infusions with a dog-specific compound of EAA, glutamate, and/or glucose (0.19 g nitrogen and/or 52–70 kcal per kg and day). Daily dialyses required by infusion volumes up to 65 ml/kg/day were performed by means of a closed batch hemodialysis system (Rhodial 75) and highly permeable membranes (RP 6), which allowed a precise ultrafiltration control and direct dialysate analysis. Comparing the urea nitrogen production in a pre- and post-nephrectomy period with a 4 successive days' schedule of only glucose, followed by amino acid administration, a marked decrease of net urea nitrogen excretion was noted after nephrectomy, when EAA were supplied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856760
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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