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  • 1
    Electronic Resource
    Electronic Resource
    Lactat- und Harnsäureretention nach oralen Diuretikagaben beim Menschen (1967)
    Springer
    Journal of molecular medicine 45 (1967), S. 1219-1220 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In man, the daily oral intake of 40 mg Furosemide produces an initial decrease in urinary lactate excretion and an increase in lactate concentration in the venous blood. This increase probably causes the initial reduction in excretion of urate. Since the changes in lactate concentration in blood and urine return to normal in spite of further treatment with Furosemide, the further retention of uric acid cannot be attributed to the effect of lactate on the kidney. Under treatment with Furosemide the retention of uric is initially extra-renal and later renal.
    Notes: Zusammenfassung Die tägliche orale Einnahme von 40 mg Furosemid führt beim Menschen zu einem initialen Abfall der Lactatausscheidung im Harn und einem Lactatanstieg im venösen Blut. Dieser Anstieg bedingt vermutlich die initiale Reduktion der Uratausscheidung. Da die Lactatveränderungen trotz weiterer Furosemidwirkung zur Norm zurückkehrten, ist eine anhaltende renale Lactatwirkung nicht an der Harnsäureretention beteiligt. Diese ist unter Furosemid primär extrarenal und dann renal bedingt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727638
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  • 2
    Electronic Resource
    Electronic Resource
    Über den Mechanismus der renalen Lactatbearbeitung beim Menschen (1969)
    Springer
    Journal of molecular medicine 47 (1969), S. 1170-1172 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Lactate is filtered in the glomeruli and reabsorbed in the tubules. The maximal rate of lactate reabsorption (Tm-Lactate) was 20 mg/min in normal and resting subjects. This value was reached by blood lactate concentrations between 13–18 mg/100 cc. At higher levels there was a fall in the calculated tubular reabsorption and tubular secretion of lactate appeared. This remarkable process occured independently of urine-pH and urine-flow.
    Notes: Zusammenfassung Lactat wird filtriert und tubulär reabsorbiert. Die maximale tubuläre Reabsorption von Lactat (Tm-Lactat) betrug beim nierengesunden, ruhenden Menschen um 20 mg/min und wurde bei einer Blutlactatkonzentration von 13–18 mg-% erreicht. Bei weiterer Steigerung des Blutlactat fand sich schließlich eine Abnahme der berechneten tubulären Reabsorption bis zum Auftreten einer zunehmenden tubulären Lactatsekretion. Dieser bemerkenswerte Vorgang läuft in dem gemessenen Bereich unabhängig vom Harn-pH und der Harnflußgröße ab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01483747
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Zum Mechanismus des Blutlactatanstiegs nach Diuretikagaben (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 1062-1064 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In normal volunteer subjects, the lactacidemia produced by oral administration of Furosemide is abolished when the latter is given in combination with Dihydroergotamine or Dextraninfusion. Thus the rise of blood lactate resulted from an increased lactate production which is due to a sympathoadrenal discharge, stimulated by a Furosemide induced plasma-volume depletion. Changes in urine lactate excretion probably are not due to a direct action of the drug on the kidney.
    Notes: Zusammenfassung An gesunden Probanden wird gezeigt, daß der Lactatanstieg im Blut unter oraler Einnahme von Furosemid durch kombinierte Einnahme mit Dihydroergotamin oder mit Hilfe von Dextran-Infusionen verhindert werden kann. Hieraus wird gefolgert, daß der Lactatanstieg auf einer vermehrten Lactatbildung infolge Stimulierung des adrenergen Systems durch eine Abnahme des Plasmavolumens beruht. Die Änderung der Lactatausscheidung kann wahrscheinlich nicht auf eine direkt renale Furosemidwirkung zurückgeführt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728553
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  • 4
    Electronic Resource
    Electronic Resource
    Parenteral nutrition and repeated hemodialysis of bilaterally nephrectomized conscious dogs (1980)
    Springer
    Research in experimental medicine 178 (1980), S. 71-74 
    Details
    ISSN: 1433-8580
    Keywords: Parenteral nutrition ; Anephric dog ; Hemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To realize equilibrated metabolic conditions after bilateral Nx, three male mongrel dogs were exclusively fed by parenteral infusions with a dog-specific compound of EAA, glutamate, and/or glucose (0.19 g nitrogen and/or 52–70 kcal per kg and day). Daily dialyses required by infusion volumes up to 65 ml/kg/day were performed by means of a closed batch hemodialysis system (Rhodial 75) and highly permeable membranes (RP 6), which allowed a precise ultrafiltration control and direct dialysate analysis. Comparing the urea nitrogen production in a pre- and post-nephrectomy period with a 4 successive days' schedule of only glucose, followed by amino acid administration, a marked decrease of net urea nitrogen excretion was noted after nephrectomy, when EAA were supplied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856760
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  • 5
    Electronic Resource
    Electronic Resource
    Sauerstoffverbrauch und Gewichtsentwicklung chronisch urämischer Ratten (1978)
    Springer
    Research in experimental medicine 173 (1978), S. 239-244 
    Details
    ISSN: 1433-8580
    Keywords: Experimental chronic uremia ; Rat ; Oxygen consumption ; Body weight ; Experimentelle chronische Urämie ; Ratte ; Sauerstoffverbrauch ; Körpergewicht
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die verminderte Gewichtszunahme bei experimenteller chronischer Urämie führte zu der Bestimmung des Sauerstoffverbrauches chronisch urämischer Ratten und eines normalen Vergleichskollektivs. Die Messung des Sauerstoffverbrauches wird als Hinweis auf den Energiebedarf des Gesamtstoffwechsels gewertet. Drei Gruppen von Versuchstieren wurden untersucht: urämische Ratten (CU) von geringerem Gewicht (403,66 ± 9,9 g) als deren gesunde Vergleichstiere (NA) (498,31 ± 26,13) und jüngere Normaltiere (NJ), welche ein annähernd ähnliches Körpergewicht wie die chronisch Niereninsuffizienten aufwiesen (376,0 ± 8,8). Signifikante Unterschiede des Sauerstoffverbrauches, bezogen auf das Körpergewicht, wurden zwischen den Gruppen NJ (0,927 ± 0,042 ml O2/mn/100 g Ratte) und beiden Gruppen CU und NA (0,788 ± 0,036 und 0,788 ± 0,028 jeweils) gefunden. Eine proportionale Verminderung der energetisch aktiven Körpermasse mag die Ursache der Sauerstoff-Meßergebnisse bei chronischer experimenteller Urämie sein.
    Notes: Summary Impaired weight gain, a common feature in experimental chronic uremia, led to compare oxygen consumption values of chronic uremic rats and their controls. Oxygen consumption measurement may allow an approach to the evaluation of total energy requirement. Three groups of animals were considered: uremic rats (CU) of less weight (402.66 ± 9.9 g) than their control group (NA) (498.31 ± 26.13) and younger normal animals (NJ), showing a similar weight (376.0 ± 8.8) to that of the uremics. Significant differences in oxygen consumption values/body weight were found between group NJ (0.927 ± 0.042 ml O2/mn/100 g rat) and both groups CU and NA (0.788 ± 0.036 and 0.788 ± 0.028 respectively). Proportional decrease of energetically active body mass in chronic uremic animals may be the reason of the findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851495
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  • 6
    Electronic Resource
    Electronic Resource
    Parenteral nutrition and repeated hemodialysis of bilaterally nephrectomized conscious dogs (1980)
    Springer
    Research in experimental medicine 177 (1980), S. 119-124 
    Details
    ISSN: 1433-8580
    Keywords: Parenteral nutrition ; Repeated hemodialyses ; Conscious anephric dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The experimental model of the anephric, daily hemodialyzed conscious dog with exclusive parenteral nutrition was realized by means of a closed batch hemodialysis system (Rhodial 75) and a highly permeable polyacrylonitrile membrane (RP 6 dialyzer). Technical details, parenteral feeding, hemodialysis, and amino acid solutions preparation were described to realize a stable condition of the animals for further metabolic analyses during the early anephric period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851840
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  • 7
    Electronic Resource
    Electronic Resource
    Continuous venovenous haemodiafiltration in the acute phase of neonatal maple syrup urine disease (1997)
    Springer
    Journal of inherited metabolic disease 20 (1997), S. 463-472 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Maple syrup urine disease results in accumulation of leucine and its metabolites, which may lead in the long term to neurological dysfunction. In acute neonatal crises, large amounts of leucine may be removed by continuous venovenous haemofiltration. This extracorporeal technique has its risks and hazards, which increase with duration of treatment. We report three neonates in life-threatening conditions due to maple syrup urine disease, treated for not more than 12h with various continuous venovenous techniques: continuous haemofiltration, haemodiafiltration and haemodialysis. The efficiency of and tolerance to these techniques was evaluated. For all three patients, plasma leucine levels decreased dramatically from 2186, 3818 and 2536 µmol/L to 1131, 1275 and 488 µmol/L, respectively. Leucine clearance obtained was 4.28 ml/min in haemodiafiltration. Their patients' neurological status improved rapidly and they have a normal developmental quotient at 22 months, 13 months, and 11 months of age, respectively. Tolerance was good except for hypothermia and drop in haematocrit in all cases. Haemodiafiltration management was more cumbersome and time consuming because it required continual adjustment of the substitution fluid flow rate to precisely balance inflow and outflow rates. We recommend continuous venovenous haemodialysis as the therapy of choice. It might be anticipated that improvement of this technique, by increasing dialysate flow rate and blood flow rate, will allow leucine concentration to be decreased below 1000 µmol/L within 6-8 h, whatever the initial level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005314025760
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    Paper (German National Licenses)
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