ISSN:
1432-2013
Keywords:
Renal denervation
;
Sodium excretion
;
Inorganic phosphate reabsorption
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of acute i.v. inorganic phosphate (P i ) loading were studied on nembutalized mongrel dogs previously subjected to unilateral splanchnicotomy (“renal denervation”). GFR (51Cr-EDTA) was not different on the intact and the denervated side, while urine output (V), sodium excretion (UNaV), and urinary excretion (UP i V) of inorganic phosphate of denervated kidneys were significantly increased at any plasma P i level. Thus, tubular reabsorption of P i in denervated kidneys was considerably depressed. Tubular transport rates of Na and P i —as expressed in per cent of the filtered load—were positively correlated in both intact and denervated organs. Besides an impairment in tubular transport of Na a depression in the reabsorption of inorganic phosphate is brought about by renal denervation. A common mechanism of action for both Na and P i can be supposed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581367
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