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  • 1
    Electronic Resource
    Electronic Resource
    Effect of splanchnicotomy on the renal excretion ofd-glucose in the anaesthetized dog (1977)
    Springer
    Pflügers Archiv 369 (1977), S. 79-84 
    Details
    ISSN: 1432-2013
    Keywords: Renal denervation ; Sodium excretion ; Glucose threshold ; Glucose reabsorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of acute intravenousd-glucose (G) loading were studied on anaesthetized, unilaterally splanchnicotomized (“renal denervation”) dogs. Glomerular filtration rate (GFR) was generally not different on the innervated and denervated side, while urine flow (V), sodium excretion (UNaV) and urinary excretion (UGV) of glucose on the splanchnicotomized side were significantly increased at any plasma G concentration. Tubular reabsorption (TG) as well as Tm of G in denervated kidneys was considerably depressed. In a series of experiments with moderately elevated plasma glucose level glucosuria on the sympathectomized side was found that seems to be the consequence of a lower threshold for G in denervated kidneys. The positive correlation between the tubular reabsorption of Na and G was not influenced by renal denervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580814
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Water and sodium excretion in unilaterally denervated normal and sodium depleted anesthetized rats before and after plasma volume repletion (1982)
    Springer
    Pflügers Archiv 393 (1982), S. 133-138 
    Details
    ISSN: 1432-2013
    Keywords: Renal denervation ; Sodium excretion ; Plasma volume ; Anesthesia ; Sodium depletion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The possible role of a reduction in plasma volume (PV) by surgery as well as the importance of dietary Na supply in denervation natriuresis have been investigated on Inactinanesthetized male rats subjected to acute unilateral renal sympathectomy. Four groups were studied: I. Normal Na diet (n=14); II. Low Na diet (boiled rice for 2 weeks)-isotonic glucose infusion (n=10); III. Low Na diet-isotonic saline infusion (n=5); IV. Normal and low Na diet rats served as conscious control (n=10). Surgery caused a 9–11% increase in hematocrit and a 15–18% decrease in PV in groups I–III. Plasma volume repletion (PVR) reverted these changes. In group I sodium excretion from both kidneys was only a fraction of that in conscious animals kept on the same diet (group IV) and marked denervation natriuresis was observed. After PVR sodium output of innervated (I) kidneys was not different from that of conscious rats but denervated (D) kidneys excreted twice that amount. In group II Na excretion was increased compared to conscious Na depleted controls, and PVR augmented further this difference. Surprisingly, the difference in urinary sodium excretion (UNaV) between I and D kidneys was absent after surgery and was minimal after PVR in this group. In group III physiological saline infusion reverted the effect of Na depletion and denervation natriuresis was present both before and after PVR. It is concluded that PV reduction does not play a major role in denervation phenomenon. In Na depleted anesthetized rats denervation natriuresis is absent or minimal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582935
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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