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  • 1
    ISSN: 1279-8517
    Keywords: Lumbar plexus ; Intercostal nerves ; Anesthesia regional ; Paravertebral block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Summary An injection of a local anesthetics in the paravertebral region produces an analgesic field on the same side of the body, a paravertebral block. One point in question about this block is whether the local anesthetic spreads from the thoracic to the lumbar level of the paravertebral region. The purpose of this study was to find how the anesthetic fluid traveled to the lumbar paravertebral region, if at all. Twelve cadavers were used in this study. 15 ml of crimson dye was injected into the paravertebral region at the 11th thoracic level. The viscerae were removed so that we could examine the dye spread. While the crimson dye spread in the endothoracic fascia posterior to the parietal pleura, it also spread downward in the fascia mostly along the splanchnic nerves. At the upper surface of the diaphragm the dye spread laterally in the fascia, and entered the abdominal cavity through the medial and lateral arcuate ligaments. In the abdominal cavity, the dye was found to have spread so widely in the transversalis fascia that the subcostal, iliohypogastric, ilioinguinal, genitofemoral, lateral femoral cutaneous and femoral nerves were involved. We concluded that the dye in the thoracic paravertebral region can enter the abdominal cavity through the medial and lateral arcuate ligaments. This study explained possible fluid communication between the thoracic and lumbar paravertebral regions and confirmed our former clinical observations. The result is important for the future clinical application of paravertebral anesthesia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1279-8517
    Keywords: Lumbar plexus ; Intercostal nerves ; Anesthesia regional ; Paravertebral block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'injection d'un anesthésique local dans la région paravertébrales entraîne une analgésie unilatérale localisée (bloc paravertébral). On pouvait se demander si l'anesthésique local diffusait du niveau thoracique au niveau lombaire de la région paravertébrale. Le but de cette étude était de définir comment le liquide anesthésique gagnait la région paravertébrale lombaire, s'il le faisait. 12 cadavres ont été utilisés dans cette étude. 15 mm de colorant rouge ont été injectés dans la région paravertébrale des cadavres au niveau de la 11ème vertèbre thoracique. Les viscères ont ensuite été enlevés pour permettre l'examen de la diffusion du colorant. Le colorant diffusait dans le fascia endothoracique en arrière de la plèvre pariétale, puis vers le bas à l'intérieur du fascia, principalement le long des nerfs splanchniques. A la face supérieure du diaphragme, il diffusait latéralement dans le fascia, et pénétrait dans la cavité abdominale au-dessous des ligaments arqués médial et latéral. Dans la cavité abdominale, le colorant diffusait largement dans le fascia transversalis de telle sorte qu'il atteignait les nerfs subcostal, ilio-hypogastrique, ilio-inguinal, génito-fémoral, cutané latéral de la cuisse, et fémoral. Nous en avons conclu que le colorant pouvait passer de la région paravertébrale thoracique dans la cavité abdominale au-dessous des ligaments arqués médial et latéral. Cette étude montre la communication possible des liquides entre les régions paravertébrales thoracique et lombaire, et corrobore nos observations cliniques préalables. Le résultat en est important pour l'utilisation clinique ultérieure des blocs paravertébraux.
    Notes: Summary An injection of a local anesthetics in the paravertebral region produces an analgesic field on the same side of the body, a paravertebral block. One point in question about this block is whether the local anesthetic spreads from the thoracic to the lumbar level of the paravertebral region. The purpose of this study was to find how the anesthetic fluid traveled to the lumbar paravertebral region, if at all. Twelve cadavers were used in this study. 15 ml of crimson dye was injected into the paravertebral region at the 11th thoracic level. The viscerae were removed so that we could examine the dye spread. While the crimson dye spread in the endothoracic fascia posterior to the parietal pleura, it also spread downward in the fascia mostly along the splanchnic nerves. At the upper surface of the diaphragm the dye spread laterally in the fascia, and entered the abdominal cavity through the medial and lateral arcuate ligaments. In the abdominal cavity, the dye was found to have spread so widely in the transversalis fascia that the subcostal, iliohypogastric, ilioinguinal, genitofemoral, lateral femoral cutaneous and femoral nerves were involved. We concluded that the dye in the thoracic paravertebral region can enter the abdominal cavity through the medial and lateral arcuate ligaments. This study explained possible fluid communication between the thoracic and lumbar paravertebral regions and confirmed our former clinical observations. The result is important for the future clinical application of paravertebral anesthesia.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    ISSN: 1435-232X
    Keywords: Key words Bovine brain-specific protein ; Chromosome mapping ; Radiation hybrid panel ; 5p15.3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Here, we report on the sequence features and chromosomal location of a novel human gene which shares significant homology with the bovine brain-specific protein p25. Based on polymerase chain reaction analysis with a human/rodent monochromosomal hybrid cell panel and a radiation hybrid panel, the gene was mapped on to p15.3 region of chromosome 5.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-232X
    Keywords: Key words Regulators of G-protein signaling proteins ; RGS6 ; Chromosome mapping ; Chromosome 14q24.3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The recently discovered regulators of G-protein signaling proteins, termed the RGS family, have been shown to modulate the functioning of G-proteins by activating the intrinsic guanosine triphosphatase (GTPase) activity of the α subunits. Here, we report the chromosomal location and tissue expression of the human regulator of RGS6 gene. The messenger RNA was ubiquitously expressed in various tissues. Polymerase chain reaction (PCR)-based analysis with a human/rodent monochromosomal hybrid panel and a radiation hybrid panel indicated that the gene was mapped between genetic markers WI-5202 and D14S277 on chromosome 14q24.3 region.
    Type of Medium: Electronic Resource
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