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  • Chemistry  (28)
  • General Chemistry  (4)
  • Cholesterol synthesis  (3)
  • Angiotensin  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Hypercholesterolaemia: simvastatin and pravastatin alter cholesterol metabolism by different mechanisms
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1082 (1991), S. 303-309 
    Details
    ISSN: 0005-2760
    Keywords: Cholesterol synthesis ; Hypercholesterolaemia ; LDL ; Pravastatin ; Simvastatin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0005-2760(91)90206-W
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the separation of functions mediated by the AV3V region
    Amsterdam : Elsevier
    Peptides 3 (1982), S. 495-499 
    Details
    ISSN: 0196-9781
    Keywords: AV3V ; Angiotensin ; Diuresis ; Drinking responses ; Hypertonic saline ; Medial preoptic area ; Medial septum ; OVLT ; SFO
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(82)90114-0
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  • 3
    Electronic Resource
    Electronic Resource
    Cellular cholesterol metabolism in mitogen-stimulated lymphocytes - Requirement for de novo synthesis
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1051 (1990), S. 138-143 
    Details
    ISSN: 0167-4889
    Keywords: (Human) ; Cholesterol synthesis ; LDL binding ; Lymphocyte proliferation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(90)90185-G
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  • 4
    Electronic Resource
    Electronic Resource
    Renin-dependent water intake in hypovolemia (1988)
    Springer
    Pflügers Archiv 412 (1988), S. 574-578 
    Details
    ISSN: 1432-2013
    Keywords: Renin ; Angiotensin ; Thirst ; Hypovolemia ; Polyethleneglycol ; Saralasin ; Captopril ; Enalapril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated. Blockade of angiotensin I converting enzyme and of angiotensin receptors was used as a pharmacological tool. A significant reduction of water intake was observed when angiotensin 1 converting enzyme was inhibited by captopril and enalapril. In PEG-treated rats with blockade of angiotensin I converting enzyme, hypertonic saline injection continued to elicit substantial drinking. Normalization of low blood pressure by vasopressin infusions in PEG and captopril treated rats did not interfere with the antidipsogenic effectiveness of converting enzyme blockade. The angiotensin II receptor antagonist, saralasin, also reduced PEG-induced drinking although less effectively than converting enzyme inhibitors. We conclude that water intake due to isotonic depletion of the extracellular fluid compartment may depend on the activity of the renin-angiotensin system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583757
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of low density lipoprotein composition on the regulation of cellular cholesterol synthesis: a comparison in diabetic and non-diabetic subjects (1993)
    Springer
    Acta diabetologica 30 (1993), S. 214-219 
    Details
    ISSN: 1432-5233
    Keywords: Cellular cholesterol ; Cholesterol synthesis ; LDL binding ; LDL composition ; Type 2 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigates compositional differences in low density lipoprotein (LDL) subfractions and their relationship to cellular cholesterol synthesis. We examined ten normocholesterolaemic (serum cholesterol 〈6.5 mM) non-diabetic subjects (group 1) and compared them with ten normocholesterolaemic (group 2) and ten hypercholesterolaemic (group 3) (serum cholesterol 〉6.5 mM) type 2 (non-insulin-dependent) diabetic patients. Serum cholesterol levels for groups 1, 2 and 3 were 5.19±0.27, 5.20±0.27 and 7.51±0.31 mM. LDL1 (density 1.006–1.028 g/l) and LDL2 (1.028–1.063 g/l) were isolated by density gradient ultracentrifugation. A significantly greater proportion of cholesterol was carried in LDL2 than LDL1 in all groups. There was a significantly lower cholesterol/protein ratio in LDL1 from the hypercholesterolaemic diabetic patients compared with controls. The LDL esterified/free cholesterol ratio was significantly greater in both LDL1 and LDL2 in the hypercholesterolaemic diabetic patients compared with the other two groups. There was a negative correlation between inhibition of cholesterol synthesis and the esterified/free cholesterol ratio of both LDL1 (r=0.56,P〈0.002) and LDL2 (r=0.63,P〈0.001). Cellular cholesterol of 41.0±0.3 μg/mg cell protein in the hypercholesterolaemic diabetic patients was also significantly higher compared with values of 30.32±2.0 and 34.1±4.2 μg/mg cell protein for the normocholesterolaemic non-diabetic and diabetic groups. In vitro LDL esterification led to a decrease in LDL receptor-mediated binding and resulted in a 40% reduction in the ability of the LDL to suppress cholesterol synthesis. The study demonstrates a relationship between the LDL esterified/free cholesterol ratio, LDL receptor binding and cellular cholesterol and may have implications for the understanding of hypercholesterolaemia in diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569932
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  • 6
    Electronic Resource
    Electronic Resource
    A note on equations of time (1955)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 1 (1955), S. 410-412 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690010321
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  • 7
    Electronic Resource
    Electronic Resource
    Experimental investigation of polarization effects in reverse osmosis (1974)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 20 (1974), S. 966-974 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: With a Mach-Zehnder interferometer, salt concentration profiles were measured in a reverse osmosis system under natural convection with the membrane in a vertical position. The measured concentration profiles compared favorably with those predicted theoretically as long as the motion remained laminar. At large distances from the leading edge, however, the flow developed a wavy pattern, especially for bulk salt concentrations in excess of 0.1 moles/liter. As expected, whenever this motion became especially pronounced, the concentration of salt at the membrane surface was less and the production rate of fresh water greater than that predicted using the laminar analysis.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690200518
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  • 8
    Electronic Resource
    Electronic Resource
    Approximate equations for time of batch fractionation (1955)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 1 (1955), S. 111-117 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Analytical expressions are obtained for the calculation of the time required for batch rectification of binary feeds which may be treated by assuming constant relative volatility and no column holdup. The equations cover constant reflux operations and varying reflux constant product operations for the two cases involving either a large or a small number of theoretical stages. The latter type of calculation has hitherto been possible only by tedious graphical methods. This paper introduces novel pseudoequilibrium curves which lead to simple equations of considerable accuracy. The equations obtained may be rearranged or modified so that other factors such as sharpness of fractionation may be represented analytically.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690010117
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  • 9
    Electronic Resource
    Electronic Resource
    Numerical solution of the Navier-Stokes equation for flow past spheres: Part II. Viscous flow around circulating spheres of low viscosity (1967)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 13 (1967), S. 220-224 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Steady state solutions of the Navier-Stokes equations for Reynolds numbers of 0.1, 1, 50, 100, and 200 have been obtained by using finite-difference methods. The effects of radial and angular step size and wall proximity have been investigated. Results were found in the form of stream function and vorticity distributions with pressure distributions and drag coefficients calculated from them. The results compare favorably with experimental data and show a steady trend from Hadamard-Rybczynski flow to boundary-layer flow after Levich-Chao-Moore. For a circulating sphere of low viscosity there is no flow separation indicated at Reynolds numbers equal to or less than 200.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690130207
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  • 10
    Electronic Resource
    Electronic Resource
    Mass transfer inside drops (1960)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 6 (1960), S. 145-149 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The transfer rates of n-butanol, cyclohexanol, and ethyl acetate into water drops have been measured for circulating and oscillating drops.Methods of allowing for the end-effect transfer have been extended and measured values compared with predictions of a model.Various mechanisms for transfer inside drops have been examined in terms of a correlation factor.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690060128
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