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  • Marathon  (3)
  • catecholamines  (3)
  • angiotensin  (2)
  • Angiotensin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Role of various vasodepressor systems in the acute hypotensive effect of captopril in man (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 1-8 
    Details
    ISSN: 1432-1041
    Keywords: hypertension ; captopril ; angiotensin ; renin ; aldosterone ; catecholamines ; prostaglandins ; kininase II ; hypotensive action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The acute hypotensive effect of captopril 25 mg was investigated in 26 hypertensive patients (11 with essential and 15 with renal arterial disease). Intra-arterial blood pressure was recorded continuously and arterial blood was sampled for renin, angiotensin I and II, aldosterone, kininase II, catecholamines and prostaglandins. Captopril led to an increase in plasma renin activity, active and total plasma renin concentration and angiotensin I, a decrease in plasma kininase II activity, angiotensin II, aldosterone, prostaglandins E2 and F2* and no change in plasma (nor)adrenaline, dopamine and inactive renin concentration. The hypotensive effect of captopril was related to the changes in plasma angiotensin II level and inversely to the change in prostaglandin E2; the correlation coefficients were low, respectively 0.61 and −0.44. It is likely that the acute hypotensive effect of captopril to some extent is related to changes in plasma angiotensin II and in prostaglandins E2 and F2*. There is no evidence for a role of the adrenergic systems in the hypotensive response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554659
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  • 2
    Electronic Resource
    Electronic Resource
    Humoral and cellular effects of the K+-channel activator cromakalim in man (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 609-611 
    Details
    ISSN: 1432-1041
    Keywords: cromakalim ; erythrocyte potassium ; potassium transport system ; renin-angiotensin-aldosterone system ; catecholamines ; atrial natriuretic peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of cromakalim, a K+-channel activator, on the plasma renin-angiotensin-aldosterone system, catecholamines and α-atrial natriuretic peptide, and on the intraerythrocyte concentration and transmembrane fluxes of Na+ and K+ has been investigated in 18 normal male subjects, in a double-blind parallel study. After a run-in period on placebo for 1 week, the subjects were treated either with placebo (n=6) or cromakalim (n=12) for 1 week. Plasma renin activity was significantly increased during cromakalim. No effect of cromakalim on plasma angiotensin II, aldosterone, adrenaline, noradrenaline and α-atrial natriuretic peptide was demonstrated. The intra-erythrocyte K+ concentration was decreased during cromakalim administration and Ca2+-dependent K+-channels in red blood cells were increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562554
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  • 3
    Electronic Resource
    Electronic Resource
    Acute haemodynamic and humoral responses to felodipine and metoprolol in mild hypertension (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 71-75 
    Details
    ISSN: 1432-1041
    Keywords: felodipine ; metoprolol ; hypertension ; aldosterone ; angiotensin ; cardiac output ; catecholamines ; pulmonary vascular resistance ; renin ; systemic vascular resistance ; haemodynamic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Oral administration of felodipine to 10 patients with mild essential hypertension acutely reduced systemic vascular resistance (SVR) by 40% after 30 min. The change in SVR was significantly related to age (r=−0.74). The reduction in the intraarterially measured brachial artery pressure was limited to 15/13 mmHg, due to a rise in cardiac output (CO). The tachycardia was sustained for 90 min, as was an elevation of plasma noradrenaline. There was a transient increase in stroke volume, associated with a reduction in pulmonary capillary wedge pressure, which was at least partly due to a reduced intravascular volume. In contrast to SVR, pulmonary vascular resistance was not affected by felodipine. Addition of intravascular metoprolol after 90 min decreased HR and CO and augmented SVR. The felodipine-induced rise in plasma renin activity (PRA) of 100% was completely reversed by metoprolol. Plasma angiotensin II (PA II) rose by 15% during felodipine, whereas plasma aldosterone concentration (PAC) was not affected. Thus, actuely administered felodipine was a potent dilator of systemic but not of pulmonary arterioles, it stimulated the sympathetic nervous system, and reduced left ventricular filling pressure. The rise in plasma renin did not result in a higher plasma aldosterone level, due partly to reduced generation of angiotensin II.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609960
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  • 4
    Electronic Resource
    Electronic Resource
    Erythrocyte 2,3-disphosphoglycerate concentration before and after a marathon in men (1988)
    Springer
    European journal of applied physiology 57 (1988), S. 452-455 
    Details
    ISSN: 1439-6327
    Keywords: Marathon ; 2,3-Diphosphoglycerate ; Erythrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) concentration was studied in 23 runners before and after a marathon race. Blood samples were drawn from an antecubital vein the morning before the race (baseline), at 3 p.m. 2 h before the start, on finishing, and 12 and 36 h later. Compared to the baseline values, erythrocyte 2,3-DPG concentration was increased (p〈0.001) immediately after the marathon from 4.62±0.14 to 5.56±0.13 μmol·ml−1 RBC and remained elevated 12 h later (5.45±0.14 μmol·ml−1 RBC): it returned to prerace values 36 h after completion of the marathon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417992
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  • 5
    Electronic Resource
    Electronic Resource
    Erythrocyte, plasma and urinary magnesium in men before and after a marathon (1988)
    Springer
    European journal of applied physiology 58 (1988), S. 252-256 
    Details
    ISSN: 1439-6327
    Keywords: Magnesium ; Erythrocytes ; Plasma ; Marathon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Erythrocyte, plasma and urinary magnesium (Mg2+) concentration was measured in 23 runners before and after a marathon race. Blood samples were drawn from an antecubital vein the morning before the race (baseline), at 3 p.m. (2 h before the start), upon finishing and 12 h later. Compared with the baseline values, the intra-erythrocyte and plasma Mg2+ were decreased (p〈0.05 or less) immediately after the marathon, from 2.13±0.16 to 2.02±0.18 mmol · l−1 cells and from 0.88±0.06 to 0.81±0.07 mmol · l−1 respectively. The Mg2+ concentration returned to pre-race values 12 h after completion of the marathon. The urinary Mg2+ excretion rate decreased (p〈0.001) from 29±13 to 5±3 μmol · min−1 during the marathon and increased (p〈0.05) 12 h after the race to 38±18 μmol · min−1. It is concluded that the reduction in plasma Mg2+ ion concentration during the marathon cannot be attributed to erythrocyte uptake, urinary excretion or loss in sweat. It is suggested that Mg2+ may be released from erythrocytes into the extracellular fluids during sustained exercise and taken up from these fluids by the adipose cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417258
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of physical training on blood pressure, plasma renin, angiotensin and catecholamines in patients with ischaemic heart disease (1984)
    Springer
    European journal of applied physiology 53 (1984), S. 219-224 
    Details
    ISSN: 1439-6327
    Keywords: Physical training ; Exercise ; Blood pressure ; Renin ; Angiotensin ; Catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighteen patients with ischaemic heart disease were trained for 3 months, three times a week. The effectiveness of the training programme was demonstrated by increases of 27% in peak oxygen uptake and 29% in exercise duration, and by a decrease in resting and submaximal heart rates. Blood pressure, however, was not significantly affected during the training period. At rest and at submaximal exercise plasma renin activity (PRA) was lower after training. Plasma angiotensin I concentration (PA I) and angiotensin II concentration (PA II) were not significantly affected. Plasma aldosterone concentration (PAC), only measured at rest, was not significantly changed after the training period, while plasma norepinephrine (PNE) and epinephrine (PE) concentrations were significantly decreased, but only at high levels of exercise. A reduced sympathetic tone after training, suggested by the lower heart rates and the tendency to a decrease in PNE, is a likely explanation for the decrease in PRA. However, despite this decrease, PA I, PA II, and PAC were not significantly changed after training; the reason for this disrepancy is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00776593
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of prolonged physical exercise on intra-erythrocyte and plasma potassium (1989)
    Springer
    European journal of applied physiology 59 (1989), S. 296-302 
    Details
    ISSN: 1439-6327
    Keywords: Marathon ; Intra-erythrocyte cations ; Sodium ; Potassium ; Aldosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The intracellular concentrations of sodium [Na+] and potassium [K+] and the water content in human erythrocytes were investigated in 21 male runners before and after a marathon. From 2 to 5 min after the race, the intra-erythrocyte [K+] was significantly decreased (p〈0.001) by 7% whereas the plasma [K+], intra-erythrocyte [Na+] and the erythrocyte water content were unchanged. The change in the intra-erythrocyte [K+] observed immediately after the marathon, was negatively correlated with the race time (r=−0.44;p〈0.05). Furthermore, the change in the plasma [K+] (r=−0.64;p〈0.001) and the amount of K+ excreted in the urine during the race (r=0.54;p〈0.05) were also, respectively, negatively and positively correlated with the race time. It is concluded that during prolonged physical exercise the erythrocytes could serve as a kind of K+ reservoir that is drained with increasing magnitude of body K+ loss. This might explain why in the faster marathon runners, in whom the urinary K+ loss is smaller and the K+ intake is greater than in the slower runners during race, the intra-erythrocyte [K+] is unchanged after a marathon whereas in the slower runners it is decreased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02388332
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