ISSN:
1420-908X
Keywords:
Nimesulide gel
;
Anti-inflammatory
;
Carrageenan
;
Formalin
;
Freund's adjuvant
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract 1|Objective and Design The anti-inflammatory activity of topically applied nimesulide gel was compared in different experimental models with that of diclofenac and piroxicam gels. 2|Material Wistar albino rats of either sex were used. 3|Treatment In acute models, 50 mg of nimesulide or diclofenac were applied to right hind paws 1 h (carrageenan) or immediately before (formalin) irritant injection (sub-plantar). In adjuvant arthritis, 50 mg of nimesulide, diclofenac or piroxicam were applied daily to injected paws for 14 days. 4|Methods Paw volume was measured by plethysmograph. Statistical significance was tested with Student's t-test. 5|Results In the carrageenan paw odema, topical nimesulide gel exhibited similar anti-inflammatory activity to diclofenac gel, and was more effective than diclofenac gel in formalin-paw odema. In both acute (18h) and chronic (14d) phases of adjuvant arthritis, nimesulide gel was more effective than diclofenac or piroxicam gels. 6|Conclusion Topical nimesulide gel possesses higher anti-inflammatory activity than that of diclofenac or piroxicam gels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02312040
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