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  • Anti-inflammatory drugs  (1)
  • Cognitive functions  (1)
  • Dopaminergic agonists  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Measurement and drug induced modulation of interleukin-1 level during zymosan peritonitis in mice (1995)
    Springer
    Inflammation research 44 (1995), S. 248-252 
    Details
    ISSN: 1420-908X
    Keywords: Interleukin-1 ; Zymosan peritonitis ; Anti-inflammatory drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The time-course and pharmacological modulation of interleukin-1 (IL-1) production were investigated during zymosan induced peritonitis in mice. IL-1α liberation was assessed by specific immunoassay (ELISA) and the IL-1 like bioactivity (sensitive to bothα- andβ-forms of IL-1) was measured by a sensitive bioassay (D10G4.1 costimulation). I.p. injection of zymosan induced significant IL-1 release into the peritoneal exudate. The level peaked at 4h and by 24h dropped below the detection limit in both assays. The effects of the prototypical antiinflammatory drugs indomethacin (IND) and dexamethasone (DEX) and that of IX 207-887, a compound which has been reported to interfere primarily with IL-1 production, were also tested. DEX and IX 207-887 dose-dependently decreased the immunoassayable IL-1α level and the IL-1 like bioactivity as well. However, IND had no suppressant effect. Thus, the data obtained by immunoassay and bioassay correlated well proving the suitability of zymosan peritonitis model for the examination of IL-1 production in experimental inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01782977
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of methysergide, bromocriptine and naloxone on prolactin, growth hormone and TSH release induced by d-Met2,Pro5-enkephalinamide in man (1986)
    Springer
    Psychopharmacology 88 (1986), S. 331-335 
    Details
    ISSN: 1432-2072
    Keywords: Opioid peptides ; d-Met2,Pro5-enkephalina-mide ; Prolactin ; Growth hormone ; TSH ; Methysergide ; Bromocriptine ; Dopaminergic agonists ; Serotonergic antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract d-Met2,Pro5-enkephalinamide (EA) 10 mg, given SC, induced a dramatic rise in serum prolactin (PRL) and growth hormone (GH) levels in healthy male volunteers. The TSH content was also moderately elevated. Naloxone 0.8 mg administered IV abolished these effects. Bromocriptine 2.5 mg given per os also antagonized EA-induced PRL and TSH release but potentiated the GH surge. Methysergide 2.0 mg administered orally partially reversed EA-elicited PRL release, further augmented GH liberation and did not modify TSH output. The data indicate that inhibition of the dopaminergic tone and/or activation of certain serotonergic mechanisms play an important role in the EA-induced release of PRL and TSH. However, primarily other neurotransmitters might mediate the GH liberation elicited by this opioid peptide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180834
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of D-Met2, Pro5-enkephalinamide on pain tolerance and some cognitive functions in man (1986)
    Springer
    Psychopharmacology 89 (1986), S. 409-413 
    Details
    ISSN: 1432-2072
    Keywords: Opiates ; Opioid peptides ; Enkephalin analogue ; Pain threshold ; Pain tolerance ; Cognitive functions ; Memory ; Attention ; D-Met2, Pro5-enkephalinamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects ofd-Met2, Pro5-enkephalinamide (EA) on pain tolerance and some cognitive functions have been examined in healthy male volunteers. Dihydrocodeine (DC) was used as reference substance. Applying the submaximum effort tourniquet technique EA (10 mg SC) was found to elevate the pain threshold similarly to DC (20 mg SC). Neither DC nor EA impaired the performance in the symbol cancellation test, which quantitates the intensity of attention. In this assay rather a slight improvement was detected. In addition the short-term memory performance (Wechsler test) was also improved by EA and DC. No alteration was seen in the word fluency test, an indicator of long-term (semantic) memory. The data show that EA not only improves pain tolerance but some of its mental effects are similar to those of a classical morphine congener DC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02412112
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    Paper (German National Licenses)
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