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Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitus (1996)

Accardo-Palumbo, A. ; Triolo, G. ; Giardina, E. ; [et al.]

Springer

Acta diabetologica 33 (1996), S. 103-107

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ISSN: 1432-5233

Keywords: Anti-myeloperoxidase antibody ; Polymorphonuclear leucocytes ; Endothelial cell ; Intercellular adhesion molecule 1 (ICAM-1)

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the occurrence of anti-MPO and anti-thyroperoxidase antibodies. Levels of soluble intercellular adhesion molecule 1 (ICAM-1) were found to be higher in anti-MPO antibodypositive (n=28, 508±126 ng/ml) than in anti-MPO antibody-negative (n=58, 438±140 ng/ml;P〈0.05) patients. A state of chronic neutrophil activation has been described in diabetes mellitus. As anti-MPO antibodies can stimulate neutrophils to damage endothelial cells in systemic vasculitis, this suggests that a similar mechanism may be operative in the development of diabetic angiopathy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00569418

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III. Yeast sequencing reports. Nucleotide sequence of 9·2 kb left of CRY1 on yeast chromosome III from strain ab972: Evidence for a ty insertion and functional analysis of open reading frame YCR28 (1992)

Carbone, M. L. Agostoni ; Panzeri, L. ; Falconi, M. Muzi ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Yeast 8 (1992), S. 805-812

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ISSN: 0749-503X

Keywords: Chromosome III ; Ty insertion ; gene disruption ; Life and Medical Sciences ; Genetics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: We report the 9210 bp sequence from a segment of yeat chromosome III cloned from strain AB972 in λPM3270. Analysis of this sequence and its comparison with the one derived from the corresponding segment of strain XJ24-24A revealed that the AB972 region contains a duplication of about 2 kb and a Ty element, which are not found in XJ24-24A and cause a quite significant rearrangement of the whole region. We performed analysis of YCR28, the largest open reading frame we found in both AB972 and XJ24-24A. YCR28 encodes a putative protein of 512 amino acids with some similarities to yeast allontoate permease. Its disruption does not cause any detectable phenotype on rich medium or on allantoate medium, while we observed a strain-dependent effect on senstivity to amino acid balance and to 3-aminotriazole, when cells were grown in synthetic medium.

Additional Material: 7 Ill.